PMID- 33895364
OWN - NLM
STAT- MEDLINE
DCOM- 20210708
LR  - 20210708
IS  - 2213-2201 (Electronic)
VI  - 9
IP  - 6
DP  - 2021 Jun
TI  - Hormonal Effects on Urticaria and Angioedema Conditions.
PG  - 2209-2219
LID - S2213-2198(21)00461-X [pii]
LID - 10.1016/j.jaip.2021.04.021 [doi]
AB  - Women appear to be more frequently affected with urticaria and angioedema. Sex 
      hormones are believed to have an important mechanistic role in regulating 
      pathways involved in these conditions. This effect is likely nonspecific for 
      chronic spontaneous urticaria (CSU) or many forms of angioedema (AE), because 
      many other chronic diseases such as asthma are also affected by sex hormones. The 
      role of sex hormones has been better elucidated for hereditary AE, because they 
      have been shown to have multiple effects including upregulation of FXII, an 
      important activator of the kallikrein pathway. However, their role in the 
      underlying pathogenesis for CSU is less clear. Autoimmunity is clearly linked to 
      CSU, which is more common in women. This suggests that sex hormones could act as 
      adjuvants in activating or upregulating autoimmune pathways. The purpose of this 
      review is to discuss in detail the role of sex hormones in CSU and AE and how a 
      better understanding of the impact hormones has on these conditions might lead to 
      new treatment advancements with better clinical outcomes.
CI  - Copyright (c) 2021 American Academy of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Bernstein, Jonathan A
AU  - Bernstein JA
AD  - Division of Immunology/Allergy Section, Department of Internal Medicine, 
      University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic 
      address: bernstja@ucmail.uc.edu.
FAU - Bouillet, Laurence
AU  - Bouillet L
AD  - National Reference Center for Angioedema (CREAK), Department of Internal 
      Medicine/Clinical Immunology, Grenoble Alpes University Hospital, Grenoble, 
      France.
FAU - Caballero, Teresa
AU  - Caballero T
AD  - Allergy Department, Hospital La Paz Institute for Health Research (IdiPaz), 
      Hospital Universitario La Paz and Center for Biomedical Research Network On Rare 
      Diseases, Madrid, Spain.
FAU - Staevska, Maria
AU  - Staevska M
AD  - Clinical Center of Allergology, Clinic of Allergy and Asthma, University Hospital 
      "Alexandrovska", Medical University of Sofia, Sofia, Bulgaria.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210422
PL  - United States
TA  - J Allergy Clin Immunol Pract
JT  - The journal of allergy and clinical immunology. In practice
JID - 101597220
SB  - IM
MH  - *Angioedema/epidemiology
MH  - Autoimmunity
MH  - Chronic Disease
MH  - *Chronic Urticaria
MH  - Female
MH  - Humans
MH  - *Urticaria/epidemiology
OTO - NOTNLM
OT  - Adjuvants
OT  - Angioedema
OT  - Autoimmunity
OT  - Chronic
OT  - FXII
OT  - Kallikrein
OT  - Sex hormones
OT  - Urticaria
EDAT- 2021/04/26 06:00
MHDA- 2021/07/09 06:00
CRDT- 2021/04/25 20:33
PHST- 2021/02/25 00:00 [received]
PHST- 2021/04/02 00:00 [revised]
PHST- 2021/04/15 00:00 [accepted]
PHST- 2021/04/26 06:00 [pubmed]
PHST- 2021/07/09 06:00 [medline]
PHST- 2021/04/25 20:33 [entrez]
AID - S2213-2198(21)00461-X [pii]
AID - 10.1016/j.jaip.2021.04.021 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol Pract. 2021 Jun;9(6):2209-2219. doi: 
      10.1016/j.jaip.2021.04.021. Epub 2021 Apr 22.