PMID- 33897321
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 1658-3612 (Electronic)
IS  - 1658-3612 (Linking)
VI  - 16
IP  - 2
DP  - 2021 Apr
TI  - Outcome analysis of antibiotic-loaded poly methyl methacrylate (PMMA) beads in 
      musculoskeletal infections.
PG  - 177-183
LID - 10.1016/j.jtumed.2020.10.015 [doi]
AB  - OBJECTIVE: Despite the availability of an extensive array of antibiotics, 
      musculoskeletal infections are not cured successfully. It is necessary to remove 
      sequestra, infected necrotic tissue, and implants. This study was undertaken to 
      assess the efficacy of poly methyl methacrylate (PMMA) beads and identify the 
      variables that influence eradication and recurrence in the treatment of 
      musculoskeletal infections. METHODS: This study was conducted on 82 patients with 
      chronic osteomyelitis who were treated over a period of 6 years at our tertiary 
      care hospital. We followed up with 71 patients for one year. Clinicoradiological 
      data for the control of infection and bone healing were assessed at the final 
      follow up visit. The correlation between antibiotic sensitivity/resistance and 
      infection was evaluated for Gentamicin + Cefuroxime and Gentamicin + Vancomycin 
      combinations. Chi-squared testing, using SPSS version 16.0, was used for 
      statistical analysis, and a p-value < 0.05 was considered significant. RESULTS: 
      Fifty-three patients (65.4%) had an exogenous route of infection. Fifty-six 
      patients (68.51%) presented with a discharging sinus on first presentation. In 42 
      patients (59%), the diagnosis was verified with a positive bacterial culture. In 
      addition, we used antibiotic beads of Gentamicin + Cefuroxime in 74 patients 
      (90%), while in 8 patients (10%), we used Gentamicin + Vancomycin, based on 
      culture and sensitivity results. Recurrence was found in five cases of 
      Gentamicin + Cefuroxime and two cases of Gentamicin + Vancomycin (p = 0.065). 
      CONCLUSION: Antibiotics containing PMMA beads are effective in the treatment of 
      chronic osteomyelitis and in preventing the recurrence of infection. It is 
      imperative to identify various factors responsible for the recurrence of 
      infection. This may help clinicians predict the prognosis of the disease and 
      minimise the risk of adverse outcomes.
CI  - (c) 2020 The Authors.
FAU - Patel, Krunal H
AU  - Patel KH
AD  - Department of Orthopaedics, Kasturba Medical College, Manipal Academy of Higher 
      Education, Manipal, India.
FAU - Bhat, Shyamasunder N
AU  - Bhat SN
AD  - Department of Orthopaedics, Kasturba Medical College, Manipal Academy of Higher 
      Education, Manipal, India.
FAU - H, Mamatha
AU  - H M
AD  - Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher 
      Education, Manipal, India.
LA  - eng
PT  - Journal Article
DEP - 20201119
PL  - Saudi Arabia
TA  - J Taibah Univ Med Sci
JT  - Journal of Taibah University Medical Sciences
JID - 101621911
PMC - PMC8046830
OTO - NOTNLM
OT  - Antibiotic-loaded bead
OT  - Infected osteosynthesis
OT  - Musculoskeletal infection
OT  - Osteomyelitis
OT  - Poly methyl methacrylate
EDAT- 2021/04/27 06:00
MHDA- 2021/04/27 06:01
PMCR- 2020/11/19
CRDT- 2021/04/26 05:47
PHST- 2020/09/05 00:00 [received]
PHST- 2020/10/20 00:00 [revised]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2021/04/26 05:47 [entrez]
PHST- 2021/04/27 06:00 [pubmed]
PHST- 2021/04/27 06:01 [medline]
PHST- 2020/11/19 00:00 [pmc-release]
AID - S1658-3612(20)30167-0 [pii]
AID - 10.1016/j.jtumed.2020.10.015 [doi]
PST - epublish
SO  - J Taibah Univ Med Sci. 2020 Nov 19;16(2):177-183. doi: 
      10.1016/j.jtumed.2020.10.015. eCollection 2021 Apr.