PMID- 33897792
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 1689-832X (Print)
IS  - 2081-2841 (Electronic)
IS  - 2081-2841 (Linking)
VI  - 13
IP  - 2
DP  - 2021 Apr
TI  - Individualized mould-based high-dose-rate brachytherapy for perinasal skin 
      tumors: technique evaluation from a dosimetric point of view.
PG  - 179-187
LID - 10.5114/jcb.2021.105286 [doi]
AB  - PURPOSE: Dosimetric treatment planning evaluations concerning patient-adapted 
      moulds for iridium-192 high-dose-rate brachytherapy are presented in this report. 
      MATERIAL AND METHODS: Six patients with perinasal skin tumors were treated with 
      individual moulds made of biocompatible epithetic materials with embedded plastic 
      applicators. Treatment plans were optimized with regard to clinical requirements, 
      and dose was calculated using standard water-based TG-43 formalism. In addition, 
      retrospective material-dependent collapsed cone calculations according to TG-186 
      protocol were evaluated to quantify the limitations of TG-43 protocol for this 
      superficial brachytherapy technique. RESULTS: The dose-volume parameters D(90), 
      V(100), and V(150) of the planning target volumes (PTVs) for TG-43 dose 
      calculations yielded 92.2% to 102.5%, 75.1% to 93.1%, and 7.4% to 41.7% of the 
      prescribed dose, respectively. The max- imum overall dose to the ipsilateral 
      eyeball as the most affected organ at risk (OAR) varied between 8.9 and 36.4 Gy. 
      TG-186 calculations with Hounsfield unit-based density allocation resulted in 
      down by -6.4%, -16.7%, and -30.0% lower average D(90), V(100), and V(150) of the 
      PTVs, with respect to the TG-43 data. The corresponding calculated OAR doses were 
      also lower. The model-based TG-186 dose calculations have considered reduced 
      backscattering due to environmental air as well as the dose-to-medium influenced 
      by the mould materials and tissue composition. The median PTV dose was robust 
      within 0.5% for simulated variations of mould material densities in the range of 
      1.0 g/cm(3) to 1.26 g/cm(3) up to 7 mm total mould thickness. CONCLUSIONS: HDR 
      contact BT with individual moulds is a safe modality for routine treatment of 
      perinasal skin tumors. The technique provides good target coverage and OARs' 
      protection, while being robust against small variances in mould material density. 
      Model-based dose calculations (TG-186) should complement TG-43 dose calculations 
      for verification purpose and quality improvement.
CI  - Copyright (c) 2021 Termedia.
FAU - Scherf, Christian
AU  - Scherf C
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Licher, Jorg
AU  - Licher J
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Mletzko, Christina
AU  - Mletzko C
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Trommel, Martin
AU  - Trommel M
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Tselis, Nikolaos
AU  - Tselis N
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Chatzikonstantinou, Georgios
AU  - Chatzikonstantinou G
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Diefenhardt, Markus
AU  - Diefenhardt M
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Rodel, Claus
AU  - Rodel C
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Kohn, Janett
AU  - Kohn J
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
FAU - Ramm, Ulla
AU  - Ramm U
AD  - Department of Radiation Oncology, University Hospital, Goethe University, 
      Frankfurt, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210414
PL  - Poland
TA  - J Contemp Brachytherapy
JT  - Journal of contemporary brachytherapy
JID - 101506276
PMC - PMC8060955
OTO - NOTNLM
OT  - TG-186
OT  - TG-43
OT  - brachytherapy
OT  - individual moulds
OT  - perinasal skin cancer
COIS- The authors report no conflict of interest.
EDAT- 2021/04/27 06:00
MHDA- 2021/04/27 06:01
PMCR- 2021/04/01
CRDT- 2021/04/26 05:50
PHST- 2020/06/17 00:00 [received]
PHST- 2021/02/22 00:00 [accepted]
PHST- 2021/04/26 05:50 [entrez]
PHST- 2021/04/27 06:00 [pubmed]
PHST- 2021/04/27 06:01 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - 43833 [pii]
AID - 10.5114/jcb.2021.105286 [doi]
PST - ppublish
SO  - J Contemp Brachytherapy. 2021 Apr;13(2):179-187. doi: 10.5114/jcb.2021.105286. 
      Epub 2021 Apr 14.