PMID- 33898785
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210428
IS  - 2405-6316 (Electronic)
IS  - 2405-6316 (Linking)
VI  - 17
DP  - 2021 Jan
TI  - Evaluating dose constraints for radiation induced liver damage following magnetic 
      resonance image guided Stereotactic Body radiotherapy.
PG  - 91-94
LID - 10.1016/j.phro.2021.01.009 [doi]
AB  - This study reports dose corresponding to visible radiation induced liver damage 
      following Stereotactic Body Radiation Therapy (SBRT) for liver metastasis, and 
      the optimal time for follow up scans using post radiation imaging. Diagnostic 
      magnetic resonance scans of nine patients treated with liver SBRT using a 0.35 T 
      MRI-guided radiotherapy system were analyzed. The dice coefficients between the 
      region of visible liver damage and the delivered dose were calculated. A median 
      dose of 35 Gy correlated most closely with the visible radiation induced liver 
      damage. We compared scans over two to nine months and observed maximal dice 
      coefficients at two to five months post radiation. We have presented a new method 
      for developing treatment planning guidelines for liver SBRT.
CI  - (c) 2021 The Author(s).
FAU - Yadav, Poonam
AU  - Yadav P
AD  - Department of Human Oncology, University of Wisconsin Hospital and Clinics, 
      United States.
FAU - Kuczmarska-Haas, Aleksandra
AU  - Kuczmarska-Haas A
AD  - Department of Human Oncology, University of Wisconsin Hospital and Clinics, 
      United States.
FAU - Musunuru, Hima Bindu
AU  - Musunuru HB
AD  - Department of Radiation Oncology, UPMC Hillman Cancer Center, University of 
      Pittsburgh School of Medicine, Pittsburgh, PA, United States.
FAU - Witt, Jacob
AU  - Witt J
AD  - Department of Human Oncology, University of Wisconsin Hospital and Clinics, 
      United States.
FAU - Blitzer, Grace
AU  - Blitzer G
AD  - Department of Human Oncology, University of Wisconsin Hospital and Clinics, 
      United States.
FAU - Mahler, Peter
AU  - Mahler P
AD  - Department of Human Oncology, University of Wisconsin Hospital and Clinics, 
      United States.
FAU - Bassetti, Michael F
AU  - Bassetti MF
AD  - Department of Human Oncology, University of Wisconsin Hospital and Clinics, 
      United States.
LA  - eng
PT  - Journal Article
DEP - 20210206
PL  - Netherlands
TA  - Phys Imaging Radiat Oncol
JT  - Physics and imaging in radiation oncology
JID - 101704276
PMC - PMC8058022
OTO - NOTNLM
OT  - MRI-guided radiotherapy
OT  - Radiation induced liver damage
OT  - SBRT
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/04/27 06:00
MHDA- 2021/04/27 06:01
PMCR- 2021/02/06
CRDT- 2021/04/26 06:01
PHST- 2020/07/12 00:00 [received]
PHST- 2021/01/25 00:00 [revised]
PHST- 2021/01/28 00:00 [accepted]
PHST- 2021/04/26 06:01 [entrez]
PHST- 2021/04/27 06:00 [pubmed]
PHST- 2021/04/27 06:01 [medline]
PHST- 2021/02/06 00:00 [pmc-release]
AID - S2405-6316(21)00009-9 [pii]
AID - 10.1016/j.phro.2021.01.009 [doi]
PST - epublish
SO  - Phys Imaging Radiat Oncol. 2021 Feb 6;17:91-94. doi: 10.1016/j.phro.2021.01.009. 
      eCollection 2021 Jan.