PMID- 33898999
OWN - NLM
STAT- MEDLINE
DCOM- 20220414
LR  - 20220430
IS  - 2662-1347 (Electronic)
IS  - 2662-1347 (Linking)
VI  - 1
IP  - 10
DP  - 2020 Oct
TI  - GD2-specific CAR T cells encapsulated in an injectable hydrogel control 
      retinoblastoma and preserve vision.
PG  - 990-997
LID - 10.1038/s43018-020-00119-y [doi]
AB  - Retinoblastoma (RB) is a pediatric retinal tumor that overexpresses the 
      ganglioside GD2. Although it is treatable in patients with early diagnosis, 
      patients may lose one or two eyes. We generated GD2-specific chimeric antigen 
      receptor T lymphocytes (GD2.CAR-Ts) and locally delivered them to mice with an 
      in-situ grafting RB. When used in combination with the local release of 
      interleukin (IL)-15 and an injectable hydrogel, we showed that GD2.CAR-Ts 
      successfully eliminate RB tumor cells without impairment of the mouse vision.
FAU - Wang, Kai
AU  - Wang K
AUID- ORCID: 0000-0002-4419-9598
AD  - Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Chen, Yuhui
AU  - Chen Y
AD  - Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel 
      Hill, Chapel Hill, NC, USA.
FAU - Ahn, Sarah
AU  - Ahn S
AD  - Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel 
      Hill, Chapel Hill, NC, USA.
AD  - Department of Microbiology and Immunology, University of North Carolina at Chapel 
      Hill, Chapel Hill, NC, USA.
FAU - Zheng, Min
AU  - Zheng M
AD  - Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Landoni, Elisa
AU  - Landoni E
AD  - Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel 
      Hill, Chapel Hill, NC, USA.
FAU - Dotti, Gianpietro
AU  - Dotti G
AUID- ORCID: 0000-0002-2639-8526
AD  - Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel 
      Hill, Chapel Hill, NC, USA.
AD  - Department of Microbiology and Immunology, University of North Carolina at Chapel 
      Hill, Chapel Hill, NC, USA.
FAU - Savoldo, Barbara
AU  - Savoldo B
AD  - Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel 
      Hill, Chapel Hill, NC, USA. bsavoldo@med.unc.edu.
AD  - Department of Pediatric Hematology-Oncology, University of North Carolina at 
      Chapel Hill, Chapel Hill, NC, USA. bsavoldo@med.unc.edu.
FAU - Han, Zongchao
AU  - Han Z
AUID- ORCID: 0000-0002-2019-395X
AD  - Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA. zongchao@med.unc.edu.
AD  - Carolina Institute for Nanomedicine, University of North Carolina at Chapel Hill, 
      Chapel Hill, NC, USA. zongchao@med.unc.edu.
AD  - Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of 
      Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 
      zongchao@med.unc.edu.
LA  - eng
GR  - P30 CA016086/CA/NCI NIH HHS/United States
GR  - R01 CA243543/CA/NCI NIH HHS/United States
GR  - R01 EY026564/EY/NEI NIH HHS/United States
GR  - R21 CA229938/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20201012
PL  - England
TA  - Nat Cancer
JT  - Nature cancer
JID - 101761119
RN  - 0 (Gangliosides)
RN  - 0 (Hydrogels)
CIN - Nat Cancer. 2020 Oct;1(10):939-940. PMID: 34693296
MH  - Animals
MH  - Gangliosides
MH  - Humans
MH  - Hydrogels
MH  - Mice
MH  - *Retinal Neoplasms/therapy
MH  - *Retinoblastoma/therapy
MH  - T-Lymphocytes
PMC - PMC8061756
MID - NIHMS1682063
COIS- Competing Interests statement The authors declare no conflicts of interest.
EDAT- 2021/04/27 06:00
MHDA- 2021/04/27 06:01
PMCR- 2021/04/22
CRDT- 2021/04/26 06:04
PHST- 2021/04/26 06:04 [entrez]
PHST- 2021/04/27 06:00 [pubmed]
PHST- 2021/04/27 06:01 [medline]
PHST- 2021/04/22 00:00 [pmc-release]
AID - 10.1038/s43018-020-00119-y [pii]
AID - 10.1038/s43018-020-00119-y [doi]
PST - ppublish
SO  - Nat Cancer. 2020 Oct;1(10):990-997. doi: 10.1038/s43018-020-00119-y. Epub 2020 
      Oct 12.