PMID- 33899078
OWN - NLM
STAT- MEDLINE
DCOM- 20211223
LR  - 20211223
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 105
IP  - 1
DP  - 2021 Jul 2
TI  - Pattern recognition receptor-initiated innate immune responses in mouse prostatic 
      epithelial cellsdouble dagger.
PG  - 113-127
LID - 10.1093/biolre/ioab076 [doi]
AB  - Three major pathogenic states of the prostate, including benign prostatic 
      hyperplasia, prostate cancer, and prostatitis, are related to the local 
      inflammation. However, the mechanisms underlying the initiation of prostate 
      inflammation remain largely unknown. Given that the innate immune responses of 
      the tissue-specific cells to microbial infection or autoantigens contribute to 
      local inflammation, this study focused on pattern recognition receptor 
      (PRR)-initiated innate immune responses in mouse prostatic epithelial cells 
      (PECs). Primary mouse PECs abundantly expressed Toll-like receptor 3 (TLR3), 
      TLR4, TLR5, melanoma differentiation-associated protein 5 (MDA5), and 
      IFN-inducible protein 16 (p204 in mouse). These PRRs can be activated by their 
      respective ligands: lipopolysaccharide (LPS) and flagellin of Gram-negative 
      bacteria for TLR4 and TLR5, polyinosinic-polycytidylic acid (poly(I:C)) for TLR3 
      and MDA5, and herpes simplex virus DNA analog (HSV60) for p204. LPS and flagellin 
      predominantly induced the expression of inflammatory cytokines, including tumor 
      necrosis factor alpha (TNFA), interleukin 6 (IL6), chemokines monocyte 
      chemoattractant protein-1 (MCP1), and C-X-C motif chemokine 10 (CXCL10). 
      Poly(I:C) and HSV60 predominantly induced the expression of type 1 interferons 
      (IFNA and IFNB) and antiviral proteins: Mx GTPase 1, 2',5'-oligoadenylate 
      synthetase 1, and IFN-stimulated gene 15. The replication of mumps virus in PECs 
      was inhibited by type 1 IFN signaling. These findings provide insights into the 
      mechanisms underlying innate immune response in the prostate.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of Society 
      for the Study of Reproduction. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Yu, Xiaoqin
AU  - Yu X
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Chen, Ran
AU  - Chen R
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Wang, Fei
AU  - Wang F
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Liu, Weihua
AU  - Liu W
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Zhang, Wenjing
AU  - Zhang W
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Gong, Maolei
AU  - Gong M
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Wu, Han
AU  - Wu H
AD  - Department of Immunology, Shenzhen University School of Medicine, Shenzhen, 
      China.
FAU - Liu, Aijie
AU  - Liu A
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Han, Ruiqin
AU  - Han R
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Chen, Yongmei
AU  - Chen Y
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Han, Daishu
AU  - Han D
AD  - School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - Animals
MH  - Epithelial Cells/immunology
MH  - Immunity, Innate/*genetics
MH  - Inflammation/genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Prostate/*immunology
MH  - Receptors, Pattern Recognition/*genetics/immunology
OTO - NOTNLM
OT  - innate immune response
OT  - microbial infection
OT  - pattern recognition receptor
OT  - prostatic epithelial cell
OT  - prostatitis
EDAT- 2021/04/27 06:00
MHDA- 2021/12/24 06:00
CRDT- 2021/04/26 06:07
PHST- 2020/10/20 00:00 [received]
PHST- 2021/01/08 00:00 [revised]
PHST- 2021/04/09 00:00 [accepted]
PHST- 2021/04/27 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
PHST- 2021/04/26 06:07 [entrez]
AID - 6246312 [pii]
AID - 10.1093/biolre/ioab076 [doi]
PST - ppublish
SO  - Biol Reprod. 2021 Jul 2;105(1):113-127. doi: 10.1093/biolre/ioab076.