PMID- 33899358
OWN - NLM
STAT- MEDLINE
DCOM- 20210507
LR  - 20210507
IS  - 1565-1088 (Print)
VI  - 23
IP  - 4
DP  - 2021 Apr
TI  - The Prevalence of Hypomagnesemia in Hospitalized Type 2 Diabetic Patients Treated 
      with Diuretics and/or Proton Pump Inhibitors.
PG  - 245-250
AB  - BACKGROUND: Hypomagnesemia (serum magnesium level < 1.7 mg/dl) occurs more 
      frequently in patients with type 2 diabetes mellitus (T2DM).Serum magnesium 
      levels are not routinely tested in hospitalized patients, including in 
      hospitalized patients with T2DM. OBJECTIVES: To evaluate the prevalence of 
      hypomagnesemia among hospitalized T2DM patients treated with proton pump 
      inhibitors (PPIs) and/or diuretics. METHODS: A total of 263 T2DM patients 
      hospitalized in general departments were included in the study and were further 
      divided into four groups: group 1 (patients not treated with PPIs or diuretics), 
      group 2 (patients treated with PPIs), group 3 (patients treated with diuretics), 
      and group 4 (patients treated with both PPIs and diuretics).  Blood and urine 
      samples were taken during the first 24 hours of admission. Electrocardiogram was 
      performed on admission. RESULTS: Of the 263 T2DM patients, 58 (22.1%) had 
      hypomagnesemia (serum magnesium level < 1.7 mg/dl). Patients in group 2 had the 
      lowest mean serum magnesium level (1.79 mg/dl +/- 0.27). Relatively more patients 
      with hypomagnesemia were found in group 2 compared to the other groups, although 
      a statistically significant difference was not observed. Significantly more 
      patients in group 3 and 4 had chronic renal failure. Patients with hypomagnesemia 
      had significantly lower serum calcium levels. CONCLUSIONS: Hospitalized T2DM 
      patients under PPI therapy are at risk for hypomagnesemia and hypocalcemia.
FAU - Mengesha, Bethlehem
AU  - Mengesha B
AD  - Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, 
      affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Levi, Daniela
AU  - Levi D
AD  - Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, 
      affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Kroonenberg, Moran
AU  - Kroonenberg M
AD  - Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, 
      affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Koren, Ronit
AU  - Koren R
AD  - Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, 
      affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Golik, Ahuva
AU  - Golik A
AD  - Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, 
      affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Koren, Shlomit
AU  - Koren S
AD  - Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, 
      affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
RN  - 0 (Diuretics)
RN  - 0 (Proton Pump Inhibitors)
RN  - I38ZP9992A (Magnesium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Aged
MH  - Calcium/*blood
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/blood/drug therapy/epidemiology
MH  - Diuretics/administration & dosage/adverse effects
MH  - Female
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Israel/epidemiology
MH  - *Kidney Failure, Chronic/diagnosis/epidemiology
MH  - Magnesium/*blood
MH  - Male
MH  - *Metabolic Diseases/diagnosis/epidemiology/etiology/metabolism
MH  - Middle Aged
MH  - Prevalence
MH  - Proton Pump Inhibitors/administration & dosage/adverse effects
EDAT- 2021/04/27 06:00
MHDA- 2021/05/08 06:00
CRDT- 2021/04/26 06:19
PHST- 2021/04/26 06:19 [entrez]
PHST- 2021/04/27 06:00 [pubmed]
PHST- 2021/05/08 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2021 Apr;23(4):245-250.