PMID- 33900346
OWN - NLM
STAT- MEDLINE
DCOM- 20210527
LR  - 20240109
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 12
IP  - 8
DP  - 2021 Apr 26
TI  - Sargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites 
      during alleviation of hyperglycemia in type 2 diabetic mice.
PG  - 3572-3585
LID - 10.1039/d0fo03329d [doi]
AB  - Type 2 diabetic mellitus (T2DM) is a complicated metabolic disorder that is now 
      considered as a major global public health problem. Fucoidan exhibits diverse 
      biological activities, especially prevention of metabolic diseases. In this 
      regard, we herein aimed to reveal the beneficial effect of Sargassum fusiforme 
      fucoidan (SFF) on high-fat diet (HFD) and streptozotocin (STZ) induced T2DM mice. 
      We noted that on the one hand, SFF significantly decreased fasting blood glucose, 
      diet and water intake, and hyperlipidemia, while on the other hand, it improved 
      glucose tolerance. Furthermore, SFF reduced epididymal fat deposition, attenuated 
      the pathological changes in heart and liver tissues, and decreased oxidative 
      stress in diabetic mice. To explore the underlying mechanisms of these 
      ameliorative effects, the gut microbiota was analyzed. Notably, SFF highly 
      enriched benign microbes including Bacteroides, Faecalibacterium and Blautia, as 
      well as increased levels of (R)-carnitine and choline in the colon of diabetic 
      mice. This may be a potential mechanism for alleviating T2DM, thus implying the 
      benefits of SFF as an adjuvant agent for T2DM treatment. Taken together, this 
      study demonstrated a promising application of fucoidan as one of the adjuvant 
      agents for the management of T2DM in the future.
FAU - Wu, Qifang
AU  - Wu Q
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com wmj@wzu.edu.cn.
FAU - Wu, Siya
AU  - Wu S
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com wmj@wzu.edu.cn.
FAU - Cheng, Yang
AU  - Cheng Y
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com wmj@wzu.edu.cn.
FAU - Zhang, Zhongshan
AU  - Zhang Z
AD  - Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, 
      Huzhou University, Huzhou Cent Hosp, Huzhou 313000, China.
FAU - Mao, Genxiang
AU  - Mao G
AUID- ORCID: 0000-0001-7061-4479
AD  - Zhejiang Provincial Key Lab of Geriatrics, Department of Geriatrics, Zhejiang 
      Hospital, Hangzhou 310013, China.
FAU - Li, Shijun
AU  - Li S
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com wmj@wzu.edu.cn.
FAU - Yang, Yue
AU  - Yang Y
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com wmj@wzu.edu.cn.
FAU - Zhang, Xu
AU  - Zhang X
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com wmj@wzu.edu.cn.
FAU - Wu, Mingjiang
AU  - Wu M
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com wmj@wzu.edu.cn.
FAU - Tong, Haibin
AU  - Tong H
AUID- ORCID: 0000-0002-7645-3458
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com wmj@wzu.edu.cn.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Polysaccharides)
RN  - 9072-19-9 (fucoidan)
SB  - IM
MH  - Adipose Tissue/drug effects/pathology
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy/pathology
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/pathology
MH  - Diet, High-Fat
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Hyperlipidemias/drug therapy
MH  - Hypoglycemic Agents/pharmacology
MH  - Intestines/*drug effects
MH  - Liver/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Myocardium/pathology
MH  - Oxidative Stress/drug effects
MH  - Polysaccharides/pharmacology/*therapeutic use
MH  - Sargassum/*chemistry
EDAT- 2021/04/27 06:00
MHDA- 2021/05/28 06:00
CRDT- 2021/04/26 12:20
PHST- 2021/04/26 12:20 [entrez]
PHST- 2021/04/27 06:00 [pubmed]
PHST- 2021/05/28 06:00 [medline]
AID - 10.1039/d0fo03329d [doi]
PST - ppublish
SO  - Food Funct. 2021 Apr 26;12(8):3572-3585. doi: 10.1039/d0fo03329d.