PMID- 33902943
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1532-6586 (Electronic)
IS  - 0161-4754 (Linking)
VI  - 44
IP  - 3
DP  - 2021 Mar
TI  - Type 2 Diabetes Mellitus Patients Manifest Greater Muscle Fatigability Than 
      Healthy Individuals During Dynamic Fatigue Protocol.
PG  - 205-220
LID - S0161-4754(20)30061-0 [pii]
LID - 10.1016/j.jmpt.2019.10.015 [doi]
AB  - OBJECTIVE: The present study aimed to investigate the electromyographic (EMG) 
      indices of muscle fatigue along with biochemical marker of fatigue-that is, blood 
      lactate-during a dynamic fatigue protocol in individuals with type 2 diabetes 
      mellitus (T2DM) vs a healthy control group. Secondarily, it aimed to examine the 
      association between EMG indices of muscle fatigue and blood lactate in these 
      patients. METHODS: Thirty-four participants took part in the study: 19 
      individuals with T2DM (age, 53.5 +/- 6.85 years) and 15 age-matched healthy 
      controls (age, 50.2 +/- 3.55 years). Participants performed a dynamic fatigue 
      protocol consisting of 5 sets of 10 repetitions each at an intensity of the 
      10-repetition maximum. Surface EMG of the vastus medialis and vastus lateralis 
      muscles was recorded during the dynamic fatigue protocol, and EMG indices such as 
      median frequency (MF), slope of MF (MF(slope)), Dimitrov muscle fatigue spectral 
      index, and root-mean-square were evaluated for each contraction across all the 5 
      sets. Blood lactate concentrations were also assessed 3 times during the fatigue 
      protocol. RESULTS: Findings revealed that EMG muscle fatigue indices such as MF, 
      MF(slope), and Dimitrov muscle fatigue spectral index were significantly altered 
      in individuals with T2DM vs healthy individuals across the sets and repetitions 
      for both the vastus medialis (P < .001) and vastus lateralis muscles (P < .001). 
      There was a significantly greater rise in blood lactate in individuals with T2DM 
      than in healthy individuals (P < .001), which was not found to be associated with 
      changes in EMG indices of muscle fatigue. CONCLUSION: Findings suggest the 
      existence of significantly greater fatigue in the knee extensor muscles of 
      individuals with T2DM than healthy individuals.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Bhati, Pooja
AU  - Bhati P
AD  - Assistant Professor, Faculty of Physiotherapy, Shree Guru Gobind Singh 
      Tricentenary University, Gurugram, Haryana-122505, India.
FAU - Singla, Deepika
AU  - Singla D
AD  - Assistant Professor, Faculty of Physiotherapy, Shree Guru Gobind Singh 
      Tricentenary University, Gurugram, Haryana-122505, India.
FAU - Masood, Sarfaraz
AU  - Masood S
AD  - Professor and Dean, Faculty of Physiotherapy & Allied Health Sciences, Shree Guru 
      Gobind Singh Tricentenary University, Gurugram, Haryana-122505, India.
FAU - Hussain, M Ejaz
AU  - Hussain ME
AD  - Assistant Professor, Faculty of Physiotherapy, Shree Guru Gobind Singh 
      Tricentenary University, Gurugram, Haryana-122505, India. Electronic address: 
      ehusain@jmi.ac.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210424
PL  - United States
TA  - J Manipulative Physiol Ther
JT  - Journal of manipulative and physiological therapeutics
JID - 7807107
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Electromyography/methods
MH  - Humans
MH  - Knee Joint/physiology
MH  - Male
MH  - Middle Aged
MH  - Muscle Contraction/*physiology
MH  - Muscle Fatigue/*physiology
MH  - Muscle, Skeletal/*physiology
MH  - Physical Endurance/physiology
MH  - Range of Motion, Articular
OTO - NOTNLM
OT  - Diabetes Mellitus, Type 2
OT  - Electromyography
OT  - Resistance Training
EDAT- 2021/04/28 06:00
MHDA- 2021/07/06 06:00
CRDT- 2021/04/27 05:58
PHST- 2019/05/07 00:00 [received]
PHST- 2019/10/11 00:00 [revised]
PHST- 2019/10/22 00:00 [accepted]
PHST- 2021/04/28 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2021/04/27 05:58 [entrez]
AID - S0161-4754(20)30061-0 [pii]
AID - 10.1016/j.jmpt.2019.10.015 [doi]
PST - ppublish
SO  - J Manipulative Physiol Ther. 2021 Mar;44(3):205-220. doi: 
      10.1016/j.jmpt.2019.10.015. Epub 2021 Apr 24.