PMID- 33902998
OWN - NLM
STAT- MEDLINE
DCOM- 20220114
LR  - 20220114
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 35
IP  - 7
DP  - 2021 Jul
TI  - Higher extracellular water to total body water ratio was associated with chronic 
      kidney disease progression in type 2 diabetes.
PG  - 107930
LID - S1056-8727(21)00108-2 [pii]
LID - 10.1016/j.jdiacomp.2021.107930 [doi]
AB  - AIM: We studied the association between extracellular volume status and chronic 
      kidney disease (CKD) progression; and the role of extracellular volume excess as 
      a potential mediator in the relationship between matrix metalloproteinases 
      (MMP)-2 and CKD progression in Type 2 diabetes mellitus (T2DM). METHODS: We 
      conducted a prospective cohort study of 1079 T2DM patients. Bioelectrical 
      impedance analysis (BIA) was performed to assess body fluid status. RESULTS: 
      After up to 8.6 years of follow-up, 471 (43.7%) patients experienced CKD 
      progression. In the fully adjusted model, extracellular water (ECW)/ total body 
      water (TBW)ratios 0.39-0.40 and > 0.40 were associated with 45% and 78% higher 
      risk of CKD progression respectively. Patients with an increase in ECW/TBW ratio 
      had 40% higher risk of CKD progression compared to those with no change or 
      reduction of ECW/TBW ratio. Higher ECW/TBW ratio accounted for 17.4% of the 
      relationship between MMP-2 and CKD progression in T2DM (p = 0.026). CONCLUSIONS: 
      Extracellular volume excess was independently associated with CKD progression in 
      T2DM. Higher ECW/TBW ratio mediated the positive association between MMP-2 and 
      CKD progression. Further studies are needed to elucidate the role of 
      extracellular volume excess in deterioration of renal function.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Low, Serena
AU  - Low S
AD  - Diabetes Centre, Admiralty Medical Centre, Singapore, Block 676, Level 4, Kampung 
      Admiralty, Woodlands Drive 71, 730676, Singapore; Clinical Research Unit, Khoo 
      Teck Puat Hospital, Singapore, 90 Yishun Central, 768828, Singapore; Lee Kong 
      Chian School of Medicine, Nanyang Technological University, Clinical Sciences 
      Building, 11 Mandalay Road, 308232, Singapore.
FAU - Pek, Sharon
AU  - Pek S
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, 90 Yishun Central, 
      768828, Singapore.
FAU - Liu, Yan Lun
AU  - Liu YL
AD  - Department of General Medicine, Khoo Teck Puat Hospital, Singapore, 90 Yishun 
      Central, Singapore.
FAU - Moh, Angela
AU  - Moh A
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, 90 Yishun Central, 
      768828, Singapore.
FAU - Ang, Keven
AU  - Ang K
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, 90 Yishun Central, 
      768828, Singapore.
FAU - Tang, Wern Ee
AU  - Tang WE
AD  - National Healthcare Group Polyclinics, Singapore, 3 Fusionopolis Link, 
      Nexus@one-north, South Tower, 138543, Singapore.
FAU - Lim, Ziliang
AU  - Lim Z
AD  - National Healthcare Group Polyclinics, Singapore, 3 Fusionopolis Link, 
      Nexus@one-north, South Tower, 138543, Singapore.
FAU - Subramaniam, Tavintharan
AU  - Subramaniam T
AD  - Diabetes Centre, Admiralty Medical Centre, Singapore, Block 676, Level 4, Kampung 
      Admiralty, Woodlands Drive 71, 730676, Singapore.
FAU - Sum, Chee Fang
AU  - Sum CF
AD  - Diabetes Centre, Admiralty Medical Centre, Singapore, Block 676, Level 4, Kampung 
      Admiralty, Woodlands Drive 71, 730676, Singapore.
FAU - Lim, Chin Leong
AU  - Lim CL
AD  - Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical 
      Sciences Building, 11 Mandalay Road, 308232, Singapore.
FAU - Ali, Yusuf
AU  - Ali Y
AD  - Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical 
      Sciences Building, 11 Mandalay Road, 308232, Singapore.
FAU - Lim, Su Chi
AU  - Lim SC
AD  - Diabetes Centre, Admiralty Medical Centre, Singapore, Block 676, Level 4, Kampung 
      Admiralty, Woodlands Drive 71, 730676, Singapore; Clinical Research Unit, Khoo 
      Teck Puat Hospital, Singapore, 90 Yishun Central, 768828, Singapore; Saw Swee 
      Hock School of Public Health, National University of Singapore, 12 Science Drive 
      2, #10-01, 117549, Singapore. Electronic address: lim.su.chi@ktph.com.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210416
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Body Composition
MH  - *Body Water
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Disease Progression
MH  - Electric Impedance
MH  - Humans
MH  - Matrix Metalloproteinase 2
MH  - Prospective Studies
MH  - *Renal Insufficiency, Chronic/complications/diagnosis/epidemiology
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Extracellular water
OT  - Type 2 diabetes
EDAT- 2021/04/28 06:00
MHDA- 2022/01/15 06:00
CRDT- 2021/04/27 06:01
PHST- 2021/01/05 00:00 [received]
PHST- 2021/03/29 00:00 [revised]
PHST- 2021/04/11 00:00 [accepted]
PHST- 2021/04/28 06:00 [pubmed]
PHST- 2022/01/15 06:00 [medline]
PHST- 2021/04/27 06:01 [entrez]
AID - S1056-8727(21)00108-2 [pii]
AID - 10.1016/j.jdiacomp.2021.107930 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2021 Jul;35(7):107930. doi: 
      10.1016/j.jdiacomp.2021.107930. Epub 2021 Apr 16.