PMID- 33904678
OWN - NLM
STAT- MEDLINE
DCOM- 20211109
LR  - 20211109
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 20
IP  - 2
DP  - 2021 Apr 17
TI  - Distribution of Myeloid and Plasmacytoid Dendritic Cell Subpopulations in 
      Peripheral Blood of Hyperprolactinemic Women.
PG  - 198-204
AB  - Dendritic cells (DCs) play key roles in regulating the immune response using the 
      specialized function of processing and presenting antigens. Prolactin (PRL), a 
      hormone produced by the pituitary gland, participates in DC maturation and 
      function. The present study was aimed to determine the frequencies of peripheral 
      blood DC subpopulations of myeloid DC (MDC) and plasmacytoid DC (PDC) in 
      hyperprolactinemic (HPRL) women compared to normal healthy volunteers. This study 
      was conducted on 70 women, including 35 HPRL patients and 35 matched healthy 
      controls, whose PRL serum levels were in the normal range (lower than 25 ng/mL). 
      Serum thyroid-stimulating hormone (TSH) levels were measured in both groups as an 
      indicator of normal thyroid function. The electrochemiluminescence immunoassay 
      method was applied to measure the serum levels of TSH and PRL. The frequencies of 
      MDC and PDC in the peripheral blood samples of both groups were determined by 
      flow cytometry. The mean serum PRL levels in the HPRL patients and healthy 
      individuals were 46.41+/-21.96 and 13.75+/-11.19, respectively (p<0.0001); however 
      TSH levels in both groups were similar and within the normal range (0.4-4.5 
      mIU/mL) (p=0.2). The frequencies of both MDC and PDC subpopulations in the 
      peripheral blood of HPRL patients were significantly lower than they were in the 
      healthy controls. However, the ratio of MDCs/PDCs in HPRL patients was not 
      significantly different between the two groups (p=0.8). Our study revealed that 
      an increased level of serum PRL may lead to a reduction in the number of MDC and 
      PDC subpopulations. These results could help clarify the complex relationship 
      between the immune system and the neuroendocrine axis and may be of potential use 
      in understanding the pathogenesis of endocrine and immune disorders.
FAU - Raeesi Nejad, Fatemeh
AU  - Raeesi Nejad F
AD  - Endocrinology and Metabolism Research Center, Institute of Basic and Clinical 
      Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran AND 
      Department of Immunology, School of Medicine, Jiroft University of Medical 
      Sciences, Jiroft, Iran. raeesinejad.f324@gmail.com.
FAU - Mohammadi, Mohammad Mahdi
AU  - Mohammadi MM
AD  - Department of Immunology, School of Medicine, Kerman University of Medical 
      Sciences, Kerman, Iran. m3mahdi@yahoo.com.
FAU - Sanjari, Mojgan
AU  - Sanjari M
AD  - Endocrinology and Metabolism Research Center, Institute of Basic and Clinical 
      Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. 
      mjnsanjari@yahoo.com.
FAU - Malkpour Afshar, Reza
AU  - Malkpour Afshar R
AD  - Department of Pathology, School of Medicine, Kerman University of Medical 
      Sciences, Kerman, Iran. r.malekpourafshar@gmail.com.
FAU - Jafari, Elham
AU  - Jafari E
AD  - Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, 
      Kerman, Iran. ejfarda@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20210417
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 9002-62-4 (Prolactin)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Hyperprolactinemia/blood/*immunology
MH  - Prolactin/blood
MH  - Thyrotropin/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Dendritic cells
OT  - Hyperprolactinemia
OT  - Myeloid
OT  - Prolactin
EDAT- 2021/04/28 06:00
MHDA- 2021/11/10 06:00
CRDT- 2021/04/27 10:09
PHST- 2020/08/20 00:00 [received]
PHST- 2020/11/05 00:00 [accepted]
PHST- 2021/04/27 10:09 [entrez]
PHST- 2021/04/28 06:00 [pubmed]
PHST- 2021/11/10 06:00 [medline]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2021 Apr 17;20(2):198-204.