PMID- 33905508
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220602
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 23
IP  - 4
DP  - 2022 Apr 8
TI  - The Modulatory Effect of Quantitative Sensory Testing in Shoulder Pain: A 
      Systematic Review and Meta-Analysis.
PG  - 733-744
LID - 10.1093/pm/pnab155 [doi]
AB  - BACKGROUND: The underlying mechanisms for shoulder pain (SP) are still widely 
      unknown. Previous reviews have reported signs of altered pain processing in SP 
      measured with quantitative sensory testing (QST). Evidence suggests that QST 
      might hold predictive value for SP after an intervention, yet it is not known 
      whether QST profiles can be modulated in response to different treatments. 
      Therefore, this systematic review and meta-analysis aimed to assess whether QST 
      parameters can be modified by interventions for patients with SP. METHODS: Three 
      databases were searched to identify eligible studies. Eligible studies had a 
      prospective design, with at least one QST variable as an outcome in conjunction 
      with an intervention measured before and after the intervention. Studies that 
      involved SP caused by spinal or brain injury and studies looking at combined 
      chronic neck pain and SP were excluded. RESULTS: Nineteen studies investigating 
      SP were eligible for inclusion in this review. Pressure pain threshold (PPT) was 
      the most frequently used QST parameter to investigate local and widespread 
      hyperalgesia. A meta-analysis was performed on data from 10 studies with a total 
      of 16 interventions. Results demonstrated an overall acute effect (<24 hours 
      after intervention) of interventions in favor of local decreased pain sensitivity 
      and remote decreased pain sensitivity when PPTs before and after interventions 
      were compared. CONCLUSIONS: This study demonstrates that interventions such as 
      exercise and manual therapy can modulate PPTs acutely, both locally and remotely, 
      in patients with SP. Further research investigating the acute and long-term 
      modulatory ability of these interventions on other QST parameters is needed in 
      patients with SP.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      American Academy of Pain Medicine. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Lyng, Kristian Damgaard
AU  - Lyng KD
AUID- ORCID: 0000-0001-8668-691X
AD  - SMI.
FAU - Thorsen, Jens Bredbjerg Brock
AU  - Thorsen JBB
AD  - SMI.
FAU - Larsen, Dennis Boye
AU  - Larsen DB
AUID- ORCID: 0000-0002-2844-7408
AD  - SMI.
AD  - Center for Neuroplasticity and Pain, Department of Health Science and Technology, 
      Faculty of Medicine, Aalborg University, Aalborg, Denmark.
FAU - Petersen, Kristian Kjaer
AU  - Petersen KK
AD  - SMI.
AD  - Center for Neuroplasticity and Pain, Department of Health Science and Technology, 
      Faculty of Medicine, Aalborg University, Aalborg, Denmark.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
MH  - Humans
MH  - Hyperalgesia/diagnosis
MH  - Pain Measurement/methods
MH  - *Pain Threshold
MH  - Prospective Studies
MH  - *Shoulder Pain/diagnosis/therapy
OTO - NOTNLM
OT  - Intervention
OT  - Modulation
OT  - Quantitative Sensory Testing
OT  - Shoulder Pain
EDAT- 2021/04/28 06:00
MHDA- 2022/04/13 06:00
CRDT- 2021/04/27 17:20
PHST- 2021/04/28 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2021/04/27 17:20 [entrez]
AID - 6255770 [pii]
AID - 10.1093/pm/pnab155 [doi]
PST - ppublish
SO  - Pain Med. 2022 Apr 8;23(4):733-744. doi: 10.1093/pm/pnab155.