PMID- 33905702
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20240226
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 902
DP  - 2021 Jul 5
TI  - Neonatal programming with sex hormones: Effect on expression of dopamine D(1) 
      receptor and neurotransmitters release in nucleus accumbens in adult male and 
      female rats.
PG  - 174118
LID - S0014-2999(21)00270-3 [pii]
LID - 10.1016/j.ejphar.2021.174118 [doi]
AB  - Steroid sex hormones produce physiological effects in reproductive and 
      non-reproductive tissues, such as the brain. In the brain, sex hormones receptors 
      are expressed in cortical, limbic and midbrain areas modulating memory, arousal, 
      fear and motivation between other behaviors. One neurotransmitters system 
      regulated by sex hormones is dopamine (DA), where during adulthood, sex hormones 
      promote neurophysiological and behavioral effects on DA systems such as 
      tuberoinfundibular (prolactin secretion), nigrostriatal (motor circuit 
      regulation) and mesocorticolimbic (driving of motivated behavior). However, the 
      long-term effects induced by neonatal exposure to sex hormones on DA release 
      induced by D(1) receptor activation and its expression in nucleus accumbens 
      (NAcc) have not been fully studied. To answer this question, neurochemical, 
      cellular and molecular techniques were used. The data show sex differences in 
      NAcc DA extracellular levels induced by D(1) receptor activation and protein 
      content of this receptor in male and female control rats. In addition, neonatal 
      programming with a single dose of TP increases the NAcc protein content of D(1) 
      receptors of adult male and female rats. Our results show new evidence related 
      with sex differences that could explain the dependence to drug of abuse in males 
      and females, which may be associated with increased reinforcing effects of drugs 
      of abuse.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Elgueta-Reyes, Maximiliano
AU  - Elgueta-Reyes M
AD  - Laboratorio de Neuroquimica y Neurofarmacologia, Centro de Neurobiologia y 
      Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de 
      Ciencias, Universidad de Valparaiso, Valparaiso, Chile; Universidad de Santiago 
      de Chile (USACH), Facultad de Ciencias Medicas, Escuela de Medicina, Centro de 
      Investigacion Biomedica y Aplicada (CIBAP), Santiago, Chile. Electronic address: 
      max.elgueta17@gmail.com.
FAU - Martinez-Pinto, Jonathan
AU  - Martinez-Pinto J
AD  - Laboratorio de Neuroquimica y Neurofarmacologia, Centro de Neurobiologia y 
      Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de 
      Ciencias, Universidad de Valparaiso, Valparaiso, Chile. Electronic address: 
      jonathan.martinez@uv.cl.
FAU - Renard, Georgina M
AU  - Renard GM
AD  - Universidad de Santiago de Chile (USACH), Facultad de Ciencias Medicas, Escuela 
      de Medicina, Centro de Investigacion Biomedica y Aplicada (CIBAP), Santiago, 
      Chile. Electronic address: georgina.renard@usach.cl.
FAU - Sotomayor-Zarate, Ramon
AU  - Sotomayor-Zarate R
AD  - Laboratorio de Neuroquimica y Neurofarmacologia, Centro de Neurobiologia y 
      Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de 
      Ciencias, Universidad de Valparaiso, Valparaiso, Chile. Electronic address: 
      ramon.sotomayor@uv.cl.
LA  - eng
PT  - Journal Article
DEP - 20210424
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Dopamine Agonists)
RN  - 0 (Drd1 protein, rat)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Receptors, Dopamine D1)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 4TI98Z838E (Estradiol)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 67287-49-4 (2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine)
RN  - VTD58H1Z2X (Dopamine)
RN  - WI93Z9138A (Testosterone Propionate)
SB  - IM
MH  - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/administration & 
      dosage/pharmacology
MH  - Aging
MH  - Animals
MH  - Animals, Newborn
MH  - Dopamine/*metabolism
MH  - Dopamine Agonists/administration & dosage/pharmacology
MH  - Estradiol/administration & dosage/pharmacology
MH  - Female
MH  - Glutamic Acid/*metabolism
MH  - Gonadal Steroid Hormones/administration & dosage/*pharmacology
MH  - Injections
MH  - Male
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/agonists/drug effects/*genetics/*metabolism
MH  - Sex Factors
MH  - Testosterone Propionate/administration & dosage/pharmacology
MH  - Time
MH  - gamma-Aminobutyric Acid/*metabolism
MH  - Rats
OTO - NOTNLM
OT  - D(1) receptor
OT  - Dopamine
OT  - GABA
OT  - Glutamate
OT  - Microdialysis
OT  - Nucleus accumbens
OT  - Sex hormones
EDAT- 2021/04/28 06:00
MHDA- 2021/09/28 06:00
CRDT- 2021/04/27 20:09
PHST- 2021/02/01 00:00 [received]
PHST- 2021/04/12 00:00 [revised]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2021/04/28 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2021/04/27 20:09 [entrez]
AID - S0014-2999(21)00270-3 [pii]
AID - 10.1016/j.ejphar.2021.174118 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2021 Jul 5;902:174118. doi: 10.1016/j.ejphar.2021.174118. Epub 
      2021 Apr 24.