PMID- 33905705
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20210630
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 197
DP  - 2021 Jun
TI  - Chemical constituents and sources of indoor PM(2.5) and cardiopulmonary function 
      in patients with chronic obstructive pulmonary disease: Estimation of individual 
      and joint effects.
PG  - 111191
LID - S0013-9351(21)00485-0 [pii]
LID - 10.1016/j.envres.2021.111191 [doi]
AB  - BACKGROUND: The cardiopulmonary effects of chemical constituents and sources of 
      indoor fine particulate matter (PM(2.5)) remain unclear. OBJECTIVES: To examine 
      the individual and joint effects of constituents of indoor PM(2.5) on 
      cardiopulmonary function of patients with chronic obstructive pulmonary disease 
      (COPD) and the role of identified sources. METHODS: This panel study recruited 43 
      stable COPD patients from November 2015 to May 2016 in Beijing, China. Daily 
      indoor and outdoor PM(2.5) were collected for five consecutive days 
      simultaneously. Twenty-four elements were measured and principal component 
      analysis was used for source appointment. Pulmonary function and blood pressure 
      (BP) were also measured at daily visit. The linear mixed-effect models were used 
      to estimate the effect of each constituent and source. Bayesian kernel machine 
      regression (BKMR) models were used to estimate the overall effect of all measured 
      constituents. RESULTS: The combustion, indoor soil/dust and road dust sources 
      were identified as the main sources of indoor PM(2.5) and combustion sources 
      contributed over 40% during the heating season. Most constituents were 
      significantly associated with elevated BP of COPD patients and the joint effects 
      of mixed exposures were also significant especially during the heating season. 
      Most associations of chemical constituents with pulmonary function were negative 
      but not statistically significant during the heating season, as was the joint 
      effect. Few associations were observed during the non-heating season. Further, we 
      observed combustion sources throughout the study period and road dust sources 
      during the heating season were significantly associated with increased BP but not 
      decreased pulmonary function. CONCLUSION: The combustion and road dust sources 
      and their related constituents of indoor PM(2.5) could cause adverse effects on 
      cardiovascular function of COPD patients especially during the heating season, 
      but the effect on pulmonary function still needs to be further studied.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Zhang, Wenlou
AU  - Zhang W
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China.
FAU - Li, Hongyu
AU  - Li H
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China.
FAU - Pan, Lu
AU  - Pan L
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China.
FAU - Xu, Junhui
AU  - Xu J
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China.
FAU - Yang, Xuan
AU  - Yang X
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China.
FAU - Dong, Wei
AU  - Dong W
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China.
FAU - Shan, Jiao
AU  - Shan J
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China.
FAU - Wu, Shaowei
AU  - Wu S
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Xi'an Jiaotong University, Xi'an, China.
FAU - Deng, Furong
AU  - Deng F
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China. Electronic address: 
      lotus321321@126.com.
FAU - Chen, Yahong
AU  - Chen Y
AD  - Department of Pulmonary and Critical Care Medicine, Peking University Third 
      Hospital, Beijing, China. Electronic address: chenyahong@vip.sina.com.
FAU - Guo, Xinbiao
AU  - Guo X
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210424
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Air Pollutants/analysis/toxicity
MH  - *Air Pollution, Indoor/adverse effects/analysis
MH  - Bayes Theorem
MH  - Beijing
MH  - China
MH  - Environmental Monitoring
MH  - Humans
MH  - Particulate Matter/analysis/toxicity
MH  - *Pulmonary Disease, Chronic Obstructive/chemically induced
OTO - NOTNLM
OT  - Cardiopulmonary function
OT  - Chemical constituents
OT  - Chronic obstructive pulmonary disease
OT  - Indoor air
OT  - Particulate matter
EDAT- 2021/04/28 06:00
MHDA- 2021/07/01 06:00
CRDT- 2021/04/27 20:09
PHST- 2021/02/15 00:00 [received]
PHST- 2021/04/08 00:00 [revised]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/04/28 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2021/04/27 20:09 [entrez]
AID - S0013-9351(21)00485-0 [pii]
AID - 10.1016/j.envres.2021.111191 [doi]
PST - ppublish
SO  - Environ Res. 2021 Jun;197:111191. doi: 10.1016/j.envres.2021.111191. Epub 2021 
      Apr 24.