PMID- 33905762
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20231107
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 457
DP  - 2021 Jun 15
TI  - Nutrition, one-carbon metabolism and arsenic methylation.
PG  - 152803
LID - S0300-483X(21)00126-8 [pii]
LID - 10.1016/j.tox.2021.152803 [doi]
AB  - Exposure to arsenic (As) is a major public health concern globally. Inorganic As 
      (InAs) undergoes hepatic methylation to form monomethyl (MMAs)- and dimethyl 
      (DMAs)-arsenical species, facilitating urinary As elimination. MMAs(III) is 
      considerably more toxic than either InAs(III) or DMAs(V), and a higher proportion 
      of MMAs in urine has been associated with risk for a wide range of adverse health 
      outcomes. Efficiency of As methylation differs substantially between species, 
      between individuals, and across populations. One-carbon metabolism (OCM) is a 
      biochemical pathway that provides methyl groups for the methylation of As, and is 
      influenced by folate and other micronutrients, such as vitamin B(12), choline, 
      betaine and creatine. A growing body of evidence has demonstrated that 
      OCM-related micronutrients play a critical role in As methylation. This review 
      will summarize observational epidemiological studies, interventions, and relevant 
      experimental evidence examining the role that OCM-related micronutrients have on 
      As methylation, toxicity of As, and risk for associated adverse health-related 
      outcomes. There is fairly robust evidence supporting the impact of folate on As 
      methylation, and some evidence from case-control studies indicating that folate 
      nutritional status influences risk for As-induced skin lesions and bladder 
      cancer. However, the potential for folate to be protective for other As-related 
      health outcomes, and the potential beneficial effects of other OCM-related 
      micronutrients on As methylation and risk for health outcomes are less well 
      studied and warrant additional research.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Abuawad, Ahlam
AU  - Abuawad A
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
FAU - Bozack, Anne K
AU  - Bozack AK
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, NY, USA; Division of Environmental Health 
      Sciences, School of Public Health, University of California, Berkeley, CA, USA.
FAU - Saxena, Roheeni
AU  - Saxena R
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
FAU - Gamble, Mary V
AU  - Gamble MV
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, NY, USA. Electronic address: 
      mvg7@cumc.columbia.edu.
LA  - eng
GR  - R01 ES030945/ES/NIEHS NIH HHS/United States
GR  - P42 ES010349/ES/NIEHS NIH HHS/United States
GR  - F31 ES032321/ES/NIEHS NIH HHS/United States
GR  - R25 GM062454/GM/NIGMS NIH HHS/United States
GR  - P30 ES009089/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210424
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Drinking Water)
RN  - 7440-44-0 (Carbon)
RN  - 935E97BOY8 (Folic Acid)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Animals
MH  - Arsenic/*metabolism/toxicity
MH  - Carbon/*metabolism
MH  - Drinking Water/adverse effects/metabolism
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Folic Acid/administration & dosage
MH  - Folic Acid Deficiency/diet therapy/epidemiology/metabolism
MH  - Food/toxicity
MH  - Humans
MH  - Methylation
MH  - Nutritional Status/drug effects/*physiology
MH  - Observational Studies as Topic/methods
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/epidemiology/metabolism
PMC - PMC8349595
MID - NIHMS1697218
OTO - NOTNLM
OT  - Arsenic
OT  - Arsenic methylation
OT  - Folate
OT  - Nutrition
OT  - One-carbon metabolism
COIS- Declaration of interests The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2021/04/28 06:00
MHDA- 2021/06/23 06:00
PMCR- 2022/06/15
CRDT- 2021/04/27 20:10
PHST- 2020/12/23 00:00 [received]
PHST- 2021/04/20 00:00 [revised]
PHST- 2021/04/22 00:00 [accepted]
PHST- 2021/04/28 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2021/04/27 20:10 [entrez]
PHST- 2022/06/15 00:00 [pmc-release]
AID - S0300-483X(21)00126-8 [pii]
AID - 10.1016/j.tox.2021.152803 [doi]
PST - ppublish
SO  - Toxicology. 2021 Jun 15;457:152803. doi: 10.1016/j.tox.2021.152803. Epub 2021 Apr 
      24.