PMID- 3390712
OWN - NLM
STAT- MEDLINE
DCOM- 19880825
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 448
IP  - 1
DP  - 1988 May 10
TI  - Occlusion of rostroventral 3rd ventricle abolishes drinking but not AVP release 
      in response to central osmotic stimulation.
PG  - 121-7
AB  - Dogs were implanted with a device for chronic cannulation of the anterior part of 
      the 3rd ventricle (A3V). Intracerebroventricular (i.c.v.) infusion of artificial 
      cerebrospinal fluid (CSF) containing 0.35 M NaCl into the A3V of 7 normally 
      hydrated dogs induced thirst (average water intake 11.8 +/- 2.0 ml.kg-1 b. wt.) 
      and significantly increased arginine-vasopressin (AVP) concentration in the blood 
      plasma from 3.4 +/- 0.3 to 8.2 +/- 1.2 pg.ml-1. When repeating the i.c.v. 
      hypertonic infusion at intervals of one week or more in two dogs, its dipsogenic 
      effect vanished within 3-5 months. X-ray analysis revealed an occlusion of the 
      rostroventral part of the A3V. Subsequent controls on 3 other dogs confirmed that 
      the dipsogenic response to i.c.v. osmotic stimulation was abolished in 
      association with similar partial occlusions of the A3V. However, this stimulus 
      still produced a significant increase of plasma AVP from 3.7 +/- 0.5 to 5.7 +/- 
      0.7 pg.ml-1 in the 5 dogs. Control of drinking in these dogs was otherwise 
      unimpaired as indicated by their normal plasma osmolalities. Histological 
      examination revealed that the loss of the dipsogenic response to i.c.v. infusion 
      of 0.35 M NaCl was in each case associated with fibrinous occlusion of the A3V 
      between its rostral wall and the mass intermedia, preventing the passage of the 
      infusate to the supraoptic and infundibular recesses.
FAU - Eriksson, S
AU  - Eriksson S
AD  - Department of Physiology I, Karolinska Institutet, Stockholm, Sweden.
FAU - Simon-Oppermann, C
AU  - Simon-Oppermann C
FAU - Simon, E
AU  - Simon E
FAU - Gray, D A
AU  - Gray DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/blood/*metabolism
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Dogs
MH  - *Drinking Behavior/drug effects
MH  - Female
MH  - Injections, Intraventricular
MH  - Male
MH  - Sodium Chloride/administration & dosage/pharmacology
MH  - Water-Electrolyte Balance
EDAT- 1988/05/10 00:00
MHDA- 1988/05/10 00:01
CRDT- 1988/05/10 00:00
PHST- 1988/05/10 00:00 [pubmed]
PHST- 1988/05/10 00:01 [medline]
PHST- 1988/05/10 00:00 [entrez]
AID - 0006-8993(88)91108-0 [pii]
AID - 10.1016/0006-8993(88)91108-0 [doi]
PST - ppublish
SO  - Brain Res. 1988 May 10;448(1):121-7. doi: 10.1016/0006-8993(88)91108-0.