PMID- 33907138
OWN - NLM
STAT- MEDLINE
DCOM- 20210506
LR  - 20230915
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 17
DP  - 2021 Apr 30
TI  - Immune activation and chronic inflammation: Is there an additional effect of HIV 
      in a geriatric population?
PG  - e25678
LID - 10.1097/MD.0000000000025678 [doi]
LID - e25678
AB  - HIV infection has become a chronic disease, with a lower mortality, but a 
      consequent increase in age-related noninfectious comorbidities. Metabolic 
      disorders have been linked to the effect of cART as well to the effects of immune 
      activation and chronic inflammation. Whereas it is known that aging is 
      intrinsically associated with hyperinflammation and immune system deterioration, 
      the relative impact of chronic HIV infection on such inflammatory and immune 
      activation has not yet been studied focusing on an elderly HIV-infected 
      population.The objectives of the study were to assess 29 blood markers of immune 
      activation and inflammation using an ultrasensitive technique, in HIV-infected 
      patients aged >/=75 years with no or 1 comorbidity (among hypertension, renal 
      disease, neoplasia, diabetes mellitus, cardiovascular disease, stroke, 
      dyslipidemia, and osteoporosis), in comparison with age-adjusted HIV-uninfected 
      individuals to identify whether biomarkers were associated with comorbidities. 
      Wilcoxon nonparametric tests were used to compare the levels of each marker 
      between control and HIV groups; logistic regression to identify biomarkers 
      associated to comorbidity in the HIV group and principal component analysis (PCA) 
      to determine clusters associated with a group or a specific comorbidity.A total 
      of 111 HIV-infected subjects were included from the Dat'AIDS cohort and compared 
      to 63 HIV-uninfected controls. In the HIV-infected group, 4 biomarkers were 
      associated with the risk of developing a comorbidity: monocyte chemoattractant 
      protein-1 (MCP-1), neurofilament light chain (NF-L), neopterin, and soluble CD14. 
      Six biomarkers (interleukin [IL]-1B, IL-7, IL-18, neopterin, sCD14, and fatty 
      acid-binding protein) were significantly higher in the HIV-infected group 
      compared to the control group, 11 biomarkers (myeloperoxydase, interleukin-1 
      receptor antagonist, tumor necrosis factor receptor 1, interferon-gamma, MCP-1, 
      tumor necrosis factor receptor 2, IL-22, ultra sensitivity C-reactive protein, 
      fibrinogen, IL-6, and NF-L) were lower. Despite those differences, PCA to 
      determine clusters associated with a group or a specific comorbidity did not 
      reveal clustering nor between healthy control and HIV-infected patients neither 
      between the presence of comorbidity within HIV-infected group.In this highly 
      selected geriatric HIV population, HIV infection does not seem to have an 
      additional impact on age-related inflammation and immune disorder. Close 
      monitoring could have led to optimize prevention and treatment of comorbidities, 
      and have limited both immune activation and inflammation in the aging HIV 
      population.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Sauce, Delphine
AU  - Sauce D
AD  - Sorbonne Universite, INSERM, Centre d'Immunologie et des Maladies Infectieuses 
      (CIMI-Paris).
FAU - Pourcher, Valerie
AU  - Pourcher V
AD  - Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Department of 
      Infectious Diseases, Pitie-Salpetriere Hospital, Pierre Louis Institute of 
      Epidemiology and Public Health, Sorbonne Universite, Paris.
FAU - Ferry, Tristan
AU  - Ferry T
AD  - Hospices Civils de Lyon, Croix-Rousse Hospital, Department of Infectious 
      Diseases, Centre International de Recherche en Infectiologie, CIRILyon.
FAU - Boddaert, Jacques
AU  - Boddaert J
AD  - Geriatrics department, Pitie-Salpetriere Hospital, UPMC.
FAU - Slama, Laurence
AU  - Slama L
AD  - Assistance Publique-Hopitaux de Paris, Department of Infectious Diseases Hotel 
      Dieu Hospital, Paris.
FAU - Allavena, Clotilde
AU  - Allavena C
AUID- ORCID: 0000-0003-1010-1270
AD  - Department of Infectious Diseases, Hotel Dieu CHU Nantes, INSERM UIC 1413, CHU 
      Nantes, France.
LA  - eng
GR  - ECTZ14598/ANRS/
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Aged
MH  - Aging/blood/*immunology
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Comorbidity
MH  - Female
MH  - France
MH  - Geriatric Assessment
MH  - HIV/*immunology
MH  - HIV Infections/*blood/*immunology
MH  - Humans
MH  - Immunity, Active
MH  - Inflammation
MH  - Inflammation Mediators/blood/*immunology
MH  - Logistic Models
MH  - Male
MH  - Principal Component Analysis
MH  - Statistics, Nonparametric
PMC - PMC8084076
COIS- The authors report no conflicts of interest.
EDAT- 2021/04/29 06:00
MHDA- 2021/05/07 06:00
PMCR- 2021/04/30
CRDT- 2021/04/28 05:48
PHST- 2020/08/25 00:00 [received]
PHST- 2021/04/06 00:00 [accepted]
PHST- 2021/04/28 05:48 [entrez]
PHST- 2021/04/29 06:00 [pubmed]
PHST- 2021/05/07 06:00 [medline]
PHST- 2021/04/30 00:00 [pmc-release]
AID - 00005792-202104300-00053 [pii]
AID - MD-D-20-08395 [pii]
AID - 10.1097/MD.0000000000025678 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Apr 30;100(17):e25678. doi: 
      10.1097/MD.0000000000025678.