PMID- 33907287
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Apr 27
TI  - The Tri-ponderal Mass Index is associated with adiposity in adolescent type 2 
      diabetes mellitus: a cross-sectional analysis.
PG  - 9111
LID - 10.1038/s41598-021-88705-7 [doi]
LID - 9111
AB  - Pediatric type 2 diabetes mellitus (T2DM) patients are often overweight or obese, 
      yet there are no validated clinical measures of adiposity to stratify 
      cardiometabolic risk in this population. The tri-ponderal mass index (TMI, 
      kg/m(3)) has recently been reported as a measure of adiposity in children, but 
      there has been no validation of the association of TMI with adiposity in 
      pediatric T2DM. We hypothesized that in children with T2DM, the TMI can serve as 
      a more accurate measure of adiposity when compared to BMI z-score, and that it is 
      associated with components of the metabolic syndrome. This is a cross-sectional 
      secondary data analysis from the Improving Renal Complications in Adolescents 
      with Type 2 Diabetes Through REsearch (iCARE) study (n = 116, age 
      10.20-17.90 years). Spearman's correlations and multivariable regression were 
      used in the analyses. When compared to DXA, TMI demonstrated significant 
      correlation with total adiposity versus BMI z-score (TMI r = 0.74, 
      p-value < 0.0001; BMI z-score r = - 0.08, p-value 0.403). In regression analyses, 
      TMI was associated with WHtR (B = 35.54, 95% CI 28.81, 42.27, p-value < 0.0001), 
      MAP dipping (B = 1.73, 95% CI 0.12, 3.33, p-value = 0.035), and HDL (B = - 5.83, 
      95% CI - 10.13, - 1.54, p-value = 0.008). In conclusion, TMI is associated with 
      adiposity and components of the metabolic syndrome in pediatric T2DM patients.
FAU - Alfaraidi, Haifa
AU  - Alfaraidi H
AD  - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, 
      Hamilton, ON, L8S 4K1, Canada.
AD  - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, 
      Ontario, Canada.
FAU - Wicklow, Brandy
AU  - Wicklow B
AD  - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, 
      Manitoba, Canada.
AD  - Children's Hospital Research Institute of Manitoba, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
FAU - Dart, Allison B
AU  - Dart AB
AD  - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, 
      Manitoba, Canada.
AD  - Children's Hospital Research Institute of Manitoba, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
FAU - Sellers, Elizabeth
AU  - Sellers E
AD  - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, 
      Manitoba, Canada.
AD  - Children's Hospital Research Institute of Manitoba, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
FAU - McGavock, Jonathan
AU  - McGavock J
AD  - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, 
      Manitoba, Canada.
AD  - Children's Hospital Research Institute of Manitoba, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
FAU - Thabane, Lehana
AU  - Thabane L
AD  - Department of Health Research Methods, Evidence and Impact, McMaster University, 
      Hamilton, Ontario, Canada.
AD  - Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
AD  - Centre for Evaluation of Medicines, Hamilton, Ontario, Canada.
AD  - Biostatistics Unit, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
FAU - Samaan, M Constantine
AU  - Samaan MC
AD  - Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, 
      Hamilton, ON, L8S 4K1, Canada. samaanc@mcmaster.ca.
AD  - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, 
      Ontario, Canada. samaanc@mcmaster.ca.
AD  - Department of Health Research Methods, Evidence and Impact, McMaster University, 
      Hamilton, Ontario, Canada. samaanc@mcmaster.ca.
AD  - Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, 
      Canada. samaanc@mcmaster.ca.
LA  - eng
GR  - MOP-343810/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210427
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
SB  - IM
MH  - Absorptiometry, Photon
MH  - *Adiposity
MH  - Adolescent
MH  - Biomarkers/blood
MH  - *Body Mass Index
MH  - Child
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/physiopathology
MH  - Pediatric Obesity/*physiopathology
PMC - PMC8079364
COIS- The authors declare no competing interests.
EDAT- 2021/04/29 06:00
MHDA- 2021/10/26 06:00
PMCR- 2021/04/27
CRDT- 2021/04/28 06:09
PHST- 2020/03/31 00:00 [received]
PHST- 2021/04/05 00:00 [accepted]
PHST- 2021/04/28 06:09 [entrez]
PHST- 2021/04/29 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/04/27 00:00 [pmc-release]
AID - 10.1038/s41598-021-88705-7 [pii]
AID - 88705 [pii]
AID - 10.1038/s41598-021-88705-7 [doi]
PST - epublish
SO  - Sci Rep. 2021 Apr 27;11(1):9111. doi: 10.1038/s41598-021-88705-7.