PMID- 33907672
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2228-7930 (Print)
IS  - 2228-7949 (Electronic)
IS  - 2228-7930 (Linking)
VI  - 11
IP  - 2
DP  - 2021 Mar-Apr
TI  - Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression 
      of NRF2 and TNFalpha and prevents ethanol-induced toxicity in rat kidney.
PG  - 134-145
AB  - OBJECTIVE: Ginger has protective effects on the kidney, however the molecular 
      mechanism of this effect has not yet been fully elucidated. Therefore, this work 
      studied molecular mechanisms of ginger effects on ethanol-induced kidney injury. 
      MATERIALS AND METHODS: Twenty-four male Sprague-Dawley rats were randomly divided 
      into four groups: control, ginger (1 g/kg/day ginger extract by oral gavage), 
      ethanol (4 g/kg/day ethanol by oral gavage) and ginger-ethanol group and treated 
      daily for 28 days. Kidney function, expression of nuclear factor erythroid 
      2-related factor 2 (NRF2) and tumor necrosis factor (TNF)-alpha genes and oxidative 
      stress parameters in kidney tissue, were evaluated. Total phenolic content (TPC) 
      and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity of ginger extract 
      were also evaluated. RESULTS: Hydroethanolic extract of ginger showed a good 
      level of DPPH scavenging activity and TPC. In the ethanol group, serum level of 
      urea, creatinine and uric acid and the expression of NRF2 and TNF-alpha significantly 
      increased compared to control group, while co-treatment with ginger in 
      ginger+ethanol group significantly ameliorated them compared to the ethanol 
      group. Ethanol exposure significantly reduced the activity of superoxide 
      dismutase  (SOD), glutathione peroxidase (GPx) and catalase (CAT) compared to the 
      control values ,while the level of malondialdehyde (MDA) significantly increased. 
      Ginger significantly ameliorated the level of MDA and activity of SOD, GPx and 
      CAT in the ginger-ethanol group compared to the ethanol group. CONCLUSION: The 
      results showed that ginger's protective effects against ethanol renotoxicity were 
      mediated via enhancing the NRF2 and TNF-alpha expression.
FAU - Fathi, Rozita
AU  - Fathi R
AD  - Department of Exercise Physiology, Faculty of Sport Science, University of 
      Mazandaran, Babolsar, Iran.
AD  - Athletic Performance and Health Research Center, University of Mazandaran, 
      Babolsar, Iran.
FAU - Akbari, Abolfazl
AU  - Akbari A
AD  - Department of Exercise Physiology, Faculty of Sport Science, University of 
      Mazandaran, Babolsar, Iran.
AD  - Department of Physiology, School of Veterinary Medicine, Shiraz University, 
      Shiraz, Iran.
FAU - Nasiri, Khadijeh
AU  - Nasiri K
AD  - Department of Exercise Physiology, Faculty of Sport Science, University of 
      Mazandaran, Babolsar, Iran.
FAU - Chardahcherik, Marjan
AU  - Chardahcherik M
AD  - Department of Biochemistry, School of Veterinary Medicine, Shiraz University, 
      Shiraz, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Avicenna J Phytomed
JT  - Avicenna journal of phytomedicine
JID - 101586220
PMC - PMC8051320
OTO - NOTNLM
OT  - Ethanol
OT  - Ginger
OT  - Kidney
OT  - NRF2
OT  - Oxidative stress
OT  - TNF-alpha
EDAT- 2021/04/29 06:00
MHDA- 2021/04/29 06:01
PMCR- 2021/03/01
CRDT- 2021/04/28 06:21
PHST- 2021/04/28 06:21 [entrez]
PHST- 2021/04/29 06:00 [pubmed]
PHST- 2021/04/29 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - AJP-11-134 [pii]
PST - ppublish
SO  - Avicenna J Phytomed. 2021 Mar-Apr;11(2):134-145.