PMID- 33908332
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20210831
IS  - 2167-9223 (Electronic)
IS  - 2167-8421 (Linking)
VI  - 22
IP  - 3-4
DP  - 2021 May
TI  - Clinicoradiological features in amyotrophic lateral sclerosis patients with 
      olfactory dysfunction.
PG  - 260-266
LID - 10.1080/21678421.2020.1859544 [doi]
AB  - Objective: Amyotrophic lateral sclerosis (ALS) is an adult-onset 
      neurodegenerative disorder characterized by motor neuron involvement. Although 
      olfactory dysfunction has been described in ALS, clinicoradiological features 
      associated with the olfactory dysfunction remain poorly understood. Methods: We 
      enrolled 30 patients with ALS and age- and sex-matched 53 healthy controls (HCs). 
      All participants underwent the odor stick identification test for Japanese 
      (OSIT-J) and clinical assessments, including disease duration, ALSFRS-R, site of 
      onset, forced vital capacity, and cognitive examinations that reflected the 
      general, executive, memory and language function. We investigated the 
      associations between OSIT-J score and clinical features and examined atrophic 
      changes by voxel-based morphometry (VBM) analysis to MRI. Results: The OSIT-J 
      score was significantly lower in ALS patients than HCs (6.9 +/- 3.2 vs. 9.8 +/- 1.9, 
      p < 0.001). In ALS, there were significant relationships between OSIT-J score and 
      age at examination, frontal assessment battery, word fluencies, digit span 
      forward, and ADAS-Jcog recognition, but not education, disease type, duration, 
      ALSFRS-R and, %VC. Multiple regression analysis with stepwise method showed the 
      only ADAS-Jcog recognition substantially predicted OSIT-J score. VBM analysis 
      with age, sex, total intracranial volume, and ADAS-Jcog recognition as covariates 
      showed OSIT-J scores were substantially correlated with atrophic changes of left 
      orbital cortex consisting of gyrus rectus and medial orbital gyrus and right 
      hippocampus in ALS. Conclusion: ALS patients could show substantial olfactory 
      dysfunction in association with orbital cortex and hippocampus involvements. The 
      olfactory examination could be a useful marker for screening of frontotemporal 
      alteration in ALS.
FAU - Masuda, Michihito
AU  - Masuda M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Watanabe, Hirohisa
AU  - Watanabe H
AD  - Department of Neurology, Fujita Health University, Toyoake, Aichi, Japan.
FAU - Ogura, Aya
AU  - Ogura A
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Ohdake, Reiko
AU  - Ohdake R
AD  - Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
FAU - Kato, Toshiyasu
AU  - Kato T
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Kawabata, Kazuya
AU  - Kawabata K
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Hara, Kazuhiro
AU  - Hara K
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Nakamura, Ryoichi
AU  - Nakamura R
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Atsuta, Naoki
AU  - Atsuta N
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Epifanio, Bagarinao
AU  - Epifanio B
AD  - Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
FAU - Katsuno, Masahisa
AU  - Katsuno M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Sobue, Gen
AU  - Sobue G
AD  - Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Amyotroph Lateral Scler Frontotemporal Degener
JT  - Amyotrophic lateral sclerosis & frontotemporal degeneration
JID - 101587185
SB  - IM
MH  - Adult
MH  - *Amyotrophic Lateral Sclerosis/complications/diagnostic imaging
MH  - Atrophy
MH  - Frontal Lobe
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Olfaction Disorders/diagnostic imaging/etiology
OTO - NOTNLM
OT  - Amyotrophic lateral sclerosis (ALS)
OT  - frontotemporal dysfunction
OT  - olfactory dysfunction
OT  - voxel-based morphometry (VBM)
EDAT- 2021/04/29 06:00
MHDA- 2021/09/01 06:00
CRDT- 2021/04/28 08:43
PHST- 2021/04/28 08:43 [entrez]
PHST- 2021/04/29 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
AID - 10.1080/21678421.2020.1859544 [doi]
PST - ppublish
SO  - Amyotroph Lateral Scler Frontotemporal Degener. 2021 May;22(3-4):260-266. doi: 
      10.1080/21678421.2020.1859544.