PMID- 33908742
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20230822
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 72
IP  - 6
DP  - 2021 Jun 1
TI  - Low-Risk Human Leukocyte Antigen Genes and Mild Villous Atrophy Typify Celiac 
      Disease With Immunoglobulin A Deficiency.
PG  - 889-893
LID - 10.1097/MPG.0000000000003129 [doi]
AB  - OBJECTIVES: We aimed to establish if in celiac disease (CD) with immunoglobulin A 
      deficiency (IgAD) duodenal histopathology is influenced by human leukocyte 
      antigen (HLA)-DQB1 *02 alleles dosage. Clinical differences between patients with 
      CD and patients with CD and IgAD (CD-IgAD) were also evaluated. METHODS: Five 
      hundred and sixteen CD and 16 patients with CD-IgAD, enrolled over the time of 
      8 years, took part in this study. The severity of duodenal histopathology and 
      frequency of CD at-risk HLA class II genes were compared in patients with CD 
      versus patients with CD-IgAD. HLA class II genotypes were subdivided into two 
      categories of genetic risk: high: HLA-DR3/DR7, -DR3/DR3, -DR4/DR4 -DR3/DR4 and 
      low: HLA-DR5/DR7, -DR3/X, -DR4/X and X/X, where X means neither -DR3 nor -DR4. 
      Then, they were compared with two types of duodenal histopathology: 0, 1, 2 and 
      3a of mild villous atrophy (MVA) and 3b and 3c of severe villous atrophy (SVA) 
      according to the Marsh-Oberhuber classification. Clinical data concerning gender, 
      number of esophagogastroduodenoscopies (EGDs) and association with other 
      autoimmune diseases were obtained from medical records. RESULTS: In comparison 
      with CD, CD-IgAD showed an increased frequency of MVA (P < 0.0001). Furthermore, 
      CD-IgAD with MVA showed an increase of HLA low-risk genotypes (P = 0.036) and 
      half HLA-DQ2 heterodimers (P = 0.0443). Interestingly, CD-IgAD demanded an 
      increased number of EGDs to reach the diagnosis of CD (P = 0.0104) and autoimmune 
      liver diseases were more frequent compared to CD (P = 0.0049). CONCLUSIONS: 
      CD-IgAD is associated with MVA, low-risk HLA class II genes, an increased number 
      of EGDs and autoimmune liver diseases.
CI  - Copyright (c) 2021 by European Society for Pediatric Gastroenterology, Hepatology, 
      and Nutrition and North American Society for Pediatric Gastroenterology, 
      Hepatology, and Nutrition.
FAU - Schirru, Enrico
AU  - Schirru E
AD  - Centro Servizi di Ateneo per gli Stabulari (CeSASt), Universita degli Studi di 
      Cagliari, Cittadella Universitaria, Monserrato, Cagliari.
FAU - Jores, Rita Desiree
AU  - Jores RD
AD  - ATS Sardegna, Poliambulatorio di Quartu Sant'Elena, Cagliari.
FAU - Rossino, Rossano
AU  - Rossino R
AD  - Dipartimento di Scienze Mediche e Sanita Pubblica, Universita degli studi di 
      Cagliari, Cittadella Universitaria, Monserrato, Cagliari.
FAU - Corpino, Mara
AU  - Corpino M
AD  - Gastroenterologia Pediatrica, Clinica Pediatrica e Malattie Rare, Ospedale 
      Pediatrico Microcitemico A. Cao, ARNAS Brotzu, Cagliari.
FAU - Cucca, Francesco
AU  - Cucca F
AD  - Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, Sassari.
AD  - Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche 
      (CNR), Monserrato, Cagliari, Italy.
FAU - Congia, Mauro
AU  - Congia M
AD  - Gastroenterologia Pediatrica, Clinica Pediatrica e Malattie Rare, Ospedale 
      Pediatrico Microcitemico A. Cao, ARNAS Brotzu, Cagliari.
AD  - Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche 
      (CNR), Monserrato, Cagliari, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - Atrophy
MH  - *Celiac Disease/complications/genetics
MH  - HLA Antigens
MH  - HLA-DR3 Antigen/genetics
MH  - Haplotypes
MH  - Humans
MH  - Immunoglobulin A
COIS- The authors report no conflicts of interest.
EDAT- 2021/04/29 06:00
MHDA- 2021/07/10 06:00
CRDT- 2021/04/28 10:24
PHST- 2021/04/29 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2021/04/28 10:24 [entrez]
AID - 00005176-202106000-00021 [pii]
AID - 10.1097/MPG.0000000000003129 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2021 Jun 1;72(6):889-893. doi: 
      10.1097/MPG.0000000000003129.