PMID- 33909067
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20221207
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 24
IP  - 8
DP  - 2021 Aug 20
TI  - Discriminative-Stimulus Effects of Synthetic Cathinones in Squirrel Monkeys.
PG  - 656-665
LID - 10.1093/ijnp/pyab017 [doi]
AB  - BACKGROUND: Synthetic cathinones display overlapping behavioral effects with 
      psychostimulants (e.g., methamphetamine [MA]) and/or entactogens (e.g., 
      3,4-methylenedioxymethaphetamine [MDMA])-presumably reflecting their dopaminergic 
      and/or serotonergic activity. The discriminative stimulus effects of MDMA thought 
      to be mediated by such activity have been well characterized in rodents but have 
      not been fully examined in nonhuman primates. METHODS: The present studies were 
      conducted to systematically evaluate the discriminative stimulus effects of 5 
      abused synthetic cathinones (methylenedioxypyrovalerone [MDPV], 
      alpha-pyrrolidinovalerophenone [alpha-PVP], methcathinone [MCAT], mephedrone, and 
      methylone) in adult male squirrel monkeys trained to distinguish intramuscular 
      injections of MA (0.1 mg/kg; n = 4) or MDMA (0.6 mg/kg; n = 4) from vehicle. 
      RESULTS: Each training drug produced dose-dependent effects and, at the highest 
      dose, full substitution. MDMA produced predominantly vehicle-like responding in 
      the MA-trained group, whereas the highest dose of MA (0.56 mg/kg) produced 
      partial substitution (approximately 90% appropriate lever responding in one-half 
      of the subjects) in the MDMA-trained group. MDPV, alpha-PVP, and MCAT produced full 
      substitution in MA-trained subjects, but, at the same or higher doses, only 
      substituted for MDMA in one-half of the subjects, consistent with primarily 
      dopaminergically mediated interoceptive effects. In contrast, mephedrone and 
      methylone fully substituted in MDMA-trained subjects but failed to fully 
      substitute for the training drug in MA-trained subjects, suggesting a primary 
      role for serotonergic actions in their interoceptive effects. CONCLUSIONS: These 
      findings suggest that differences in the interoceptive effects of synthetic 
      cathinones in nonhuman primates reflect differing compositions of monoaminergic 
      actions that also may mediate their subjective effects in humans.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of CINP.
FAU - Wakeford, Alison G P
AU  - Wakeford AGP
AD  - McLean Hospital, Behavioral Biology Program, Belmont, Massachusetts, USA.
AD  - Harvard Medical School, Department of Psychiatry, Boston, Massachusetts, USA.
FAU - Sherwood, Alexander M
AU  - Sherwood AM
AD  - College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA.
AD  - Usona Institute, Madison, Wisconsin, USA.
FAU - Prisinzano, Thomas E
AU  - Prisinzano TE
AD  - College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA.
FAU - Bergman, Jack
AU  - Bergman J
AD  - McLean Hospital, Behavioral Biology Program, Belmont, Massachusetts, USA.
AD  - Harvard Medical School, Department of Psychiatry, Boston, Massachusetts, USA.
FAU - Kohut, Stephen J
AU  - Kohut SJ
AD  - McLean Hospital, Behavioral Biology Program, Belmont, Massachusetts, USA.
AD  - Harvard Medical School, Department of Psychiatry, Boston, Massachusetts, USA.
FAU - Paronis, Carol A
AU  - Paronis CA
AD  - McLean Hospital, Behavioral Biology Program, Belmont, Massachusetts, USA.
AD  - Harvard Medical School, Department of Psychiatry, Boston, Massachusetts, USA.
LA  - eng
GR  - R01 DA043700/DA/NIDA NIH HHS/United States
GR  - P20 GM113117/GM/NIGMS NIH HHS/United States
GR  - R01 DA048150/DA/NIDA NIH HHS/United States
GR  - R01 DA002519/DA/NIDA NIH HHS/United States
GR  - K01 DA039306/DA/NIDA NIH HHS/United States
GR  - R24 GM111385/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Alkaloids)
RN  - 0 (Benzodioxoles)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Propiophenones)
RN  - 0 (Psychotropic Drugs)
RN  - 0 (Pyrrolidines)
RN  - 0 (alpha-pyrrolidinovalerophenone)
RN  - 386QA522QG (monomethylpropion)
RN  - 44RAL3456C (Methamphetamine)
RN  - 540EI4406J (cathinone)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - L4I4B1R01F (methylone)
RN  - 0 (Synthetic Cathinone)
SB  - IM
MH  - Alkaloids/administration & dosage/*pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Benzodioxoles/pharmacology
MH  - Central Nervous System Stimulants/administration & dosage/*pharmacology
MH  - Discrimination Learning/*drug effects
MH  - Interoception/*drug effects
MH  - Male
MH  - Methamphetamine/administration & dosage/analogs & derivatives/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Propiophenones/pharmacology
MH  - Psychotropic Drugs/administration & dosage/*pharmacology
MH  - Pyrrolidines/pharmacology
MH  - Saimiri
MH  - Synthetic Cathinone
PMC - PMC8378080
OTO - NOTNLM
OT  - MDMA
OT  - Methamphetamine
OT  - drug-discrimination
OT  - monkeys
EDAT- 2021/04/29 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/04/28
CRDT- 2021/04/28 12:21
PHST- 2020/10/27 00:00 [received]
PHST- 2021/04/06 00:00 [revised]
PHST- 2021/04/26 00:00 [accepted]
PHST- 2021/04/29 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/04/28 12:21 [entrez]
PHST- 2021/04/28 00:00 [pmc-release]
AID - 6257213 [pii]
AID - pyab017 [pii]
AID - 10.1093/ijnp/pyab017 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2021 Aug 20;24(8):656-665. doi: 10.1093/ijnp/pyab017.