PMID- 33909267
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20211222
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 31
IP  - 8
DP  - 2021 Aug
TI  - Five-year Changes in Body Composition in Type 2 Diabetes Mellitus Patients with a 
      BMI < 32.5 kg/m(2) Undergoing Laparoscopic Roux-en-Y Gastric Bypass Surgery.
PG  - 3565-3570
LID - 10.1007/s11695-021-05430-w [doi]
AB  - PURPOSE: Information is scarce on the five-year effect of laparoscopic Roux-en-Y 
      Gastric Bypass (LRYGB) on body composition for Type 2 diabetes mellitus (T2DM) 
      patients with a low BMI. This study aimed to evaluate the five-year changes in 
      body composition in a Chinese T2DM cohort with a BMI < 32.5 kg/m(2) after LRYGB. 
      METHODS: Twenty-seven T2DM patients were assessed preoperatively (baseline) and 3 
      months, 6 months, 1 year, 3 years, and 5 years after LRYGB with dual-energy X-ray 
      absorptiometry (DXA). RESULTS: DXA assessments were completed in 100%, 85%, 85%, 
      85%, 48%, and 37% at baseline and 3 months, 6 months, 1 year, 3 years, and 5 
      years, respectively. For the whole body, fat-free mass and muscle mass decreased 
      from 6 months to 5 years after LRYGB (P < 0.05), while bone mineral content 
      decreased at 5 years after LRYGB (P < 0.05). Fat mass of different regions 
      decreased from 3 months to 1 year (P < 0.05), and a similar magnitude of 
      variation was observed in body fat mass percentage. A fat redistribution 
      characterized by the regional fat proportion of trunk and android decreasing and 
      the regional fat proportion of limbs gaining (P < 0.05) occurred at 5 years after 
      LRYGB. CONCLUSION: For low BMI patients with T2DM, LRYGB led to a short-term 
      reduction in FM and a lasting reduction in FFM. A metabolically healthy fat 
      redistribution occurring 5 years after LRYGB might be a promising mechanism to 
      explain the lasting benefits of LRYGB for T2DM patients with a low BMI.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Cui, Beibei
AU  - Cui B
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Sun, Xulong
AU  - Sun X
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Li, Weizheng
AU  - Li W
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Li, Pengzhou
AU  - Li P
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Wang, Guohui
AU  - Wang G
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Yu, Zhaomei
AU  - Yu Z
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Tang, Haibo
AU  - Tang H
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Ling, Jiapu
AU  - Ling J
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Yi, Xianhao
AU  - Yi X
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China.
FAU - Zhu, Liyong
AU  - Zhu L
AUID- ORCID: 0000-0003-2696-4177
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China. zly8128@csu.edu.cn.
FAU - Zhu, Shaihong
AU  - Zhu S
AD  - Department of General Surgery, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, Hunan, China. shzhu@csu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210428
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - Body Composition
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/complications/surgery
MH  - *Gastric Bypass
MH  - Humans
MH  - *Laparoscopy
MH  - *Obesity, Morbid/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Body composition
OT  - Dual-energy X-ray absorptiometry
OT  - Roux-en-Y gastric bypass
OT  - Type 2 diabetes mellitus
EDAT- 2021/04/29 06:00
MHDA- 2021/07/21 06:00
CRDT- 2021/04/28 12:29
PHST- 2021/01/10 00:00 [received]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/04/13 00:00 [revised]
PHST- 2021/04/29 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
PHST- 2021/04/28 12:29 [entrez]
AID - 10.1007/s11695-021-05430-w [pii]
AID - 10.1007/s11695-021-05430-w [doi]
PST - ppublish
SO  - Obes Surg. 2021 Aug;31(8):3565-3570. doi: 10.1007/s11695-021-05430-w. Epub 2021 
      Apr 28.