PMID- 33910626
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210502
IS  - 0778-7367 (Print)
IS  - 2049-3258 (Electronic)
IS  - 0778-7367 (Linking)
VI  - 79
IP  - 1
DP  - 2021 Apr 28
TI  - Identification of a prognostic long noncoding RNA signature in lung squamous cell 
      carcinoma: a population-based study with a mean follow-up of 3.5 years.
PG  - 61
LID - 10.1186/s13690-021-00588-2 [doi]
LID - 61
AB  - BACKGROUND: Lung squamous cell carcinoma (LSCC) is a form of cancer that is 
      associated with high rates of relapse, poor responsiveness to therapy, and a 
      relatively poor prognosis. The relationship between long non-coding RNA (lncRNA) 
      expression and LSCC patient prognosis remains to be established. METHODS: In the 
      present study, we discovered that lncRNAs were differentially expressed in LSCC 
      tumor tissues relative to normal control tissues, and we explored the prognostic 
      relevance of these lncRNA expression patterns using data from the Cancer Genome 
      Atlas (TCGA). RESULTS: These multidimensional data were analyzed in order to 
      identify lncRNA signatures that were associated with LSCC patient survival 
      outcomes. Kaplan-Meier survival curves revealed prognostic capabilities for three 
      of these lncRNAs (LINC02555, APCDD1L-DT and OTX2-AS1). A Cox regression analysis 
      revealed this three-lncRNA signature to be significantly associated with patient 
      survival. Further GO and KEGG analyses revealed that the predicted target genes 
      of these three lncRNAs were also potentially involved in cancer-associated 
      pathways. CONCLUSIONS: Together these results thus indicate that this novel 
      three-lncRNA signature can be used to predict LSCC patient prognosis.
FAU - Zheng, Rongjiong
AU  - Zheng R
AD  - Ningbo Urology and Nephrology Hospital, Ningbo Yinzhou No 2. Hospital, Ningbo, 
      China.
FAU - Zheng, Mengdi
AU  - Zheng M
AD  - Ningbo Urology and Nephrology Hospital, Ningbo Yinzhou No 2. Hospital, Ningbo, 
      China.
FAU - Wang, Mingming
AU  - Wang M
AUID- ORCID: 0000-0003-2808-5889
AD  - Ningbo Urology and Nephrology Hospital, Ningbo Yinzhou No 2. Hospital, Ningbo, 
      China.
FAU - Lu, Feijie
AU  - Lu F
AD  - Ningbo Urology and Nephrology Hospital, Ningbo Yinzhou No 2. Hospital, Ningbo, 
      China. 184852837@qq.com.
FAU - Hu, Meiling
AU  - Hu M
AD  - Cixi People's Hospital of Zhejiang Province, Zhejiang, China. 
      humeiling826@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210428
PL  - England
TA  - Arch Public Health
JT  - Archives of public health = Archives belges de sante publique
JID - 9208826
PMC - PMC8082628
OTO - NOTNLM
OT  - LncRNAs
OT  - Lung squamous cell carcinoma
OT  - Survival
COIS- No competing interests exist.
EDAT- 2021/04/30 06:00
MHDA- 2021/04/30 06:01
PMCR- 2021/04/28
CRDT- 2021/04/29 05:37
PHST- 2020/08/17 00:00 [received]
PHST- 2021/04/18 00:00 [accepted]
PHST- 2021/04/29 05:37 [entrez]
PHST- 2021/04/30 06:00 [pubmed]
PHST- 2021/04/30 06:01 [medline]
PHST- 2021/04/28 00:00 [pmc-release]
AID - 10.1186/s13690-021-00588-2 [pii]
AID - 588 [pii]
AID - 10.1186/s13690-021-00588-2 [doi]
PST - epublish
SO  - Arch Public Health. 2021 Apr 28;79(1):61. doi: 10.1186/s13690-021-00588-2.