PMID- 33910843
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20220531
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 35
IP  - 3
DP  - 2021 May-Jun
TI  - Impact of K-Ras Over-expression in Laryngeal Squamous Cell Carcinoma.
PG  - 1611-1615
LID - 10.21873/invivo.12418 [doi]
AB  - BACKGROUND/AIM: Oncogene up-regulation combined with suppressor gene 
      down-regulation is a crucial genetic combination that promotes cell neoplastic 
      phenotype and progressively malignant transformation in solid malignancies, 
      including laryngeal squamous cell carcinoma (LSCC). Among oncogenes, the Kirsten 
      ras oncogene homolog (K-Ras) is involved in LSCC onset and progression. PATIENTS 
      AND METHODS: Sixty (n=60) primary LSCC tissue sections were analyzed by 
      immunohistochemistry (IHC). Digital image analysis (DIA) was also implemented for 
      measuring K-Ras protein expression levels. RESULTS: High K-Ras protein expression 
      levels were observed in 20/60 (33.3%) LSCC tissue sections, whereas the rest of 
      the cases (n=40; 66.7%) demonstrated low expression. Overall K-Ras expression was 
      borderline significantly associated to the grade of the examined malignancies 
      (p=0.048), whereas no other strong statistical correlations were identified. A 
      progressive K-Ras overexpression was observed in all grades of the examined 
      cases. CONCLUSION: K-Ras over expression is correlated to a progressive 
      dedifferentiation in LSCC.
CI  - Copyright(c) 2021, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Papanikolaou, Vasileios
AU  - Papanikolaou V
AD  - 1 ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
FAU - Chrysovergis, Aristeidis
AU  - Chrysovergis A
AD  - 1 ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
FAU - Mastronikolis, Stylianos
AU  - Mastronikolis S
AD  - Medical School, University of Heraklion, Heraklion, Greece.
FAU - Tsiambas, Evangelos
AU  - Tsiambas E
AD  - Department of Cytology, 417 VA Hospital (NIMTS), Athens, Greece; 
      tsiambasecyto@yahoo.gr.
FAU - Ragos, Vasileios
AU  - Ragos V
AD  - Department of Maxillofacial Surgery, Medical School, University of Ioannina, 
      Ioannina, Greece.
FAU - Peschos, Dimitrios
AU  - Peschos D
AD  - Department of Physiology, Medical School, University of Ioannina, Ioannina, 
      Greece.
FAU - Spyropoulou, Despoina
AU  - Spyropoulou D
AD  - Department of Radiation Oncology, Medical School, University of Patras, Patras, 
      Greece.
FAU - Pantos, Pavlos
AU  - Pantos P
AD  - 1 ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
FAU - Niotis, Athanasios
AU  - Niotis A
AD  - Department of Surgery, 417 VA Hospital (NIMTS), Athens, Greece.
FAU - Mastronikolis, Nicholas
AU  - Mastronikolis N
AD  - ENT Department, Medical School, University of Patras, Patras, Greece.
FAU - Kyrodimos, Efthymios
AU  - Kyrodimos E
AD  - 1 ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (KRAS protein, human)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
SB  - IM
MH  - *Carcinoma, Squamous Cell/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, ras
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/genetics
MH  - Proto-Oncogene Proteins p21(ras)
MH  - Squamous Cell Carcinoma of Head and Neck
PMC - PMC8193306
OTO - NOTNLM
OT  - Carcinoma
OT  - K-Ras
OT  - larynx
OT  - oncogene
COIS- The Authors declare no conflicts of interest regarding this study. No financial 
      support was granted.
EDAT- 2021/04/30 06:00
MHDA- 2021/06/22 06:00
PMCR- 2021/05/03
CRDT- 2021/04/29 05:45
PHST- 2021/02/03 00:00 [received]
PHST- 2021/03/06 00:00 [revised]
PHST- 2021/03/08 00:00 [accepted]
PHST- 2021/04/29 05:45 [entrez]
PHST- 2021/04/30 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/05/03 00:00 [pmc-release]
AID - 35/3/1611 [pii]
AID - 10.21873/invivo.12418 [doi]
PST - ppublish
SO  - In Vivo. 2021 May-Jun;35(3):1611-1615. doi: 10.21873/invivo.12418.