PMID- 33911454
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240401
IS  - 0974-777X (Print)
IS  - 0974-8245 (Electronic)
IS  - 0974-777X (Linking)
VI  - 13
IP  - 1
DP  - 2021 Jan-Mar
TI  - Intravenous Immunoglobulin for Overwhelming Postsplenectomy Infection.
PG  - 44-51
LID - 10.4103/jgid.jgid_93_19 [doi]
AB  - Overwhelming postsplenectomy infection (OPSI) is a life-threatening condition 
      causing fulminant bacteremia in asplenic patients. Intravenous immunoglobulin 
      (IVIG) therapy is theoretically effective for OPSI. Herein, we present a case of 
      OPSI treated successfully with IVIG, along with results of a literature review. 
      An asplenic 70-year-old male with acute ischemic stroke presented with rapid and 
      fulminant septic shock from pneumococcus pneumonia and bacteremia. Resuscitation 
      and antibiotics including IVIG therapy were instituted. The patient survived with 
      favorable outcomes. We analyzed all case reports or case series of OPSI from 1971 
      through 2017. Cases with IVIG treatment showed a significantly higher survival 
      rate than those without IVIG, even with multivariable regression analysis, 
      suggesting IVIG as an independent predictive factor for survival. It suggests 
      that IVIG is effective for OPSI and that it can be regarded as an adjunctive 
      treatment option for OPSI.
CI  - Copyright: (c) 2021 Journal of Global Infectious Diseases.
FAU - Nakamura, Kensuke
AU  - Nakamura K
AD  - Department of Emergency and Critical Care Medicine, Hitachi General Hospital, 
      Hitachi, Ibaraki, Japan.
FAU - Takahashi, Yuji
AU  - Takahashi Y
AD  - Department of Emergency and Critical Care Medicine, Hitachi General Hospital, 
      Hitachi, Ibaraki, Japan.
FAU - Sonoo, Tomohiro
AU  - Sonoo T
AD  - Department of Emergency and Critical Care Medicine, Hitachi General Hospital, 
      Hitachi, Ibaraki, Japan.
FAU - Hashimoto, Hideki
AU  - Hashimoto H
AD  - Department of Emergency and Critical Care Medicine, Hitachi General Hospital, 
      Hitachi, Ibaraki, Japan.
LA  - eng
PT  - Case Reports
DEP - 20210129
PL  - India
TA  - J Glob Infect Dis
JT  - Journal of global infectious diseases
JID - 101521436
PMC - PMC8054784
OTO - NOTNLM
OT  - Intravenous immunoglobulin
OT  - overwhelming postsplenectomy infection
OT  - sepsis
OT  - splenectomy
COIS- There are no conflicts of interest.
EDAT- 2021/04/30 06:00
MHDA- 2021/04/30 06:01
PMCR- 2021/01/29
CRDT- 2021/04/29 06:21
PHST- 2019/07/23 00:00 [received]
PHST- 2020/02/04 00:00 [revised]
PHST- 2020/05/20 00:00 [accepted]
PHST- 2021/04/29 06:21 [entrez]
PHST- 2021/04/30 06:00 [pubmed]
PHST- 2021/04/30 06:01 [medline]
PHST- 2021/01/29 00:00 [pmc-release]
AID - JGID-13-44 [pii]
AID - 10.4103/jgid.jgid_93_19 [doi]
PST - epublish
SO  - J Glob Infect Dis. 2021 Jan 29;13(1):44-51. doi: 10.4103/jgid.jgid_93_19. 
      eCollection 2021 Jan-Mar.