PMID- 33912413
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2223-8956 (Electronic)
IS  - 1016-3190 (Print)
IS  - 1016-3190 (Linking)
VI  - 33
IP  - 2
DP  - 2021 Apr-Jun
TI  - The diagnostic and prognostic utility of insulin growth factor of squamous cell 
      carcinoma in oral cavity.
PG  - 160-164
LID - 10.4103/tcmj.tcmj_50_20 [doi]
AB  - OBJECTIVE: The present study was conducted to find the utility of insulin growth 
      factors (IGFs) as diagnostic and prognostic biochemical parameters in patients 
      suffering from squamous cell carcinoma of oral cavity. MATERIALS AND METHODS: A 
      total of 360 male and female patients diagnosed with precancerous conditions 
      (PCC) and oral squamous cell carcinoma (OSCC) of Stage I to IV were selected for 
      the present study. Patients were interviewed using a structured questionnaire to 
      ascertain their demographic and medical history. After completing the history and 
      physical examination, patients were subjected to routine blood investigations 
      along with determining insulin growth factor (IGF-1, IGFBP-3) levels. The data 
      obtained were then subjected to statistical analysis using SPSS 20.0 version. 
      RESULTS: The mean values of IGF-1, insulin-like growth factor-binding protein-3 
      (IGFBP-3), and ratio of IGF-1 and IGFBP-3 were obtained. The intergroup 
      comparison was done between PCC and all the stages of OSCC for all the IGFs. The 
      result obtained was found to be statistically significant (P < 0.05). CONCLUSION: 
      The present study concluded that a positive correlation was observed for various 
      insulin growth factors (IGF-1, IGFBP-3; and ratio of IGF-1 and IGFBP-3) between 
      OSCC and PCC such as erythroplakia and oral submucous fibrosis. Thus, the study 
      highlighted the use of IGFs as diagnostic and prognostic parameters in patients 
      suffering from cancerous conditions.
CI  - Copyright: (c) 2020 Tzu Chi Medical Journal.
FAU - Tiwari, Sumit Kumar
AU  - Tiwari SK
AD  - Department of Biochemistry, S.M.S. Medical College and Attached Hospitals, 
      Jaipur, Rajasthan, India.
FAU - Saini, Shakuntala
AU  - Saini S
AD  - Department of Biochemistry, S.M.S. Medical College and Attached Hospitals, 
      Jaipur, Rajasthan, India.
FAU - Singhal, Pawan
AU  - Singhal P
AD  - Department of ENT, S.M.S. Medical College and Attached Hospitals, Jaipur, 
      Rajasthan, India.
FAU - Mathur, Ashwin
AU  - Mathur A
AD  - Department of Medicine, S.M.S. Medical College and Attached Hospitals, Jaipur, 
      Rajasthan, India.
FAU - Sinha, Maheep
AU  - Sinha M
AD  - Department of Biochemistry, Mahatma Gandhi Medical College and Hospital, Jaipur, 
      Rajasthan, India.
LA  - eng
PT  - Journal Article
DEP - 20200825
PL  - India
TA  - Tzu Chi Med J
JT  - Tzu chi medical journal
JID - 101770275
PMC - PMC8059461
OTO - NOTNLM
OT  - Insulin growth factor
OT  - Oral squamous cell carcinoma
OT  - Precancerous conditions
OT  - Tumo-node-metastasis staging
COIS- There are no conflicts of interest.
EDAT- 2021/04/30 06:00
MHDA- 2021/04/30 06:01
PMCR- 2020/08/25
CRDT- 2021/04/29 06:29
PHST- 2020/03/27 00:00 [received]
PHST- 2020/05/27 00:00 [revised]
PHST- 2020/06/10 00:00 [accepted]
PHST- 2021/04/29 06:29 [entrez]
PHST- 2021/04/30 06:00 [pubmed]
PHST- 2021/04/30 06:01 [medline]
PHST- 2020/08/25 00:00 [pmc-release]
AID - TCMJ-33-160 [pii]
AID - 10.4103/tcmj.tcmj_50_20 [doi]
PST - epublish
SO  - Tzu Chi Med J. 2020 Aug 25;33(2):160-164. doi: 10.4103/tcmj.tcmj_50_20. 
      eCollection 2021 Apr-Jun.