PMID- 33913796
OWN - NLM
STAT- MEDLINE
DCOM- 20220711
LR  - 20220711
IS  - 1471-1753 (Electronic)
IS  - 0954-6634 (Linking)
VI  - 33
IP  - 4
DP  - 2022 Jun
TI  - The risk of hepatic adverse events of systemic medications for psoriasis: a 
      prospective cohort study using the BIOBADADERM registry.
PG  - 2110-2117
LID - 10.1080/09546634.2021.1922572 [doi]
AB  - BACKGROUND: Limited information is available regarding the risk of incident liver 
      disease in patients with psoriasis receiving systemic therapies. OBJECTIVES: To 
      describe the liver safety findings of conventional and modern systemic therapies 
      for moderate-to-severe psoriasis, and to compare the relative incidence rates of 
      hepatic adverse events (AEs) for each drug. METHODS: All the patients on the 
      BIOBADADERM registry were included. Crude and adjusted incidence rate ratios 
      (cIRR and aIRR, respectively) of hepatic AEs, using anti-TNF drugs as reference, 
      were determined. Outcomes of interest were hypertransaminasemia, nonalcoholic 
      fatty liver disease (NADFLD) and a group of other, less represented, hepatic AEs. 
      RESULTS: Our study included 3,171 patients exposed to systemic drugs (6279 
      treatment cycles). Incident hypertransaminasemia was the most frequent hepatic AE 
      (incidence rate of 21 per 1000 patients-years [CI 95% 18-23]), followed by NAFLD 
      (8 cases per 1000 patients-years [95% CI 6-10]). Methotrexate (aIRR 3.06 
      [2.31-4.4]; p = 0.000) and cyclosporine (aIRR 2.37 [1.05-5.35]; p = .0378) were 
      associated with an increased risk for hypertransaminasemia when compared to 
      anti-TNF-alpha agents. No differences were observed between different groups of 
      biologics. Conventional therapies were not associated with new incident NAFLD. 
      CONCLUSIONS: Comparative information of the incidence of hepatic AEs could 
      facilitate drug selection in moderate-to-severe psoriasis.
FAU - Munera-Campos, Monica
AU  - Munera-Campos M
AUID- ORCID: 0000-0002-2227-2993
AD  - Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, 
      Universidad Autonoma de Barcelona, Barcelona, Spain.
FAU - Vilar-Alejo, Jaime
AU  - Vilar-Alejo J
AD  - Department of Dermatology, Hospital Universitario de Gran Canaria Dr. Negrin, Las 
      Palmas de Gran Canaria, Spain.
FAU - Rivera, Raquel
AU  - Rivera R
AD  - Department of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain.
FAU - Carrascosa, Jose-Manuel
AU  - Carrascosa JM
AUID- ORCID: 0000-0003-4266-0771
AD  - Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, 
      Universidad Autonoma de Barcelona, Barcelona, Spain.
FAU - Dauden, Esteban
AU  - Dauden E
AD  - Department of Dermatology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria de La Princesa (IIS-IP). Madrid, Spain.
FAU - Herrera-Acosta, Enrique
AU  - Herrera-Acosta E
AD  - Department of Dermatology, Hospital Universitario Virgen de la Victoria, Malaga, 
      Spain.
FAU - Sahuquillo-Torralba, Antonio
AU  - Sahuquillo-Torralba A
AD  - Department of Dermatology, Hospital Universitario y Politecnico La Fe, Valencia, 
      Spain.
FAU - Gomez-Garcia, Francisco J
AU  - Gomez-Garcia FJ
AD  - Department of Dermatology, Hospital Universitario Reina Sofia, Cordoba, Spain.
FAU - Baniandres-Rodriguez, Ofelia
AU  - Baniandres-Rodriguez O
AD  - Department of Dermatology, CEIMI Hospital General Universitario Gregorio Maranon, 
      Madrid, Spain.
FAU - de la Cueva, Pablo
AU  - de la Cueva P
AD  - Department of Dermatology, Hospital Universitario Infanta Leonor, Madrid, Spain.
FAU - Lopez-Estebaranz, Jose-Luis
AU  - Lopez-Estebaranz JL
AD  - Department of Dermatology, Hospital Universitario Fundacion Alcorcon, Madrid, 
      Spain.
FAU - Belinchon, Isabel
AU  - Belinchon I
AD  - Department of Dermatology, Hospital General Universitario de Alicante-ISABIAL, 
      Alicante, Spain.
FAU - Ferran, Marta
AU  - Ferran M
AD  - Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
FAU - Riera-Monroig, Jose
AU  - Riera-Monroig J
AD  - Department of Dermatology, Hospital Clinic de Barcelona, UB, Barcelona, Spain.
FAU - Rodriguez, Lourdes
AU  - Rodriguez L
AD  - Department of Dermatology, Hospital Virgen del Rocio, Sevilla, Spain.
FAU - Carretero, Gregorio
AU  - Carretero G
AD  - Department of Dermatology, Hospital Universitario de Gran Canaria Dr. Negrin, Las 
      Palmas de Gran Canaria, Spain.
FAU - Garcia-Donoso, Carmen
AU  - Garcia-Donoso C
AD  - Department of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain.
FAU - Ballesca, Ferran
AU  - Ballesca F
AD  - Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, 
      Universidad Autonoma de Barcelona, Barcelona, Spain.
FAU - Llamas-Velasco, Mar
AU  - Llamas-Velasco M
AD  - Department of Dermatology, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria de La Princesa (IIS-IP). Madrid, Spain.
FAU - Herrera-Ceballos, Enrique
AU  - Herrera-Ceballos E
AD  - Department of Dermatology, Hospital Universitario Virgen de la Victoria, Malaga, 
      Spain.
FAU - Pujol-Marco, Conrad
AU  - Pujol-Marco C
AD  - Department of Dermatology, Hospital Universitario y Politecnico La Fe, Valencia, 
      Spain.
FAU - Nieto-Benito, Lula Maria
AU  - Nieto-Benito LM
AUID- ORCID: 0000-0002-7609-2736
AD  - Department of Dermatology, CEIMI Hospital General Universitario Gregorio Maranon, 
      Madrid, Spain.
FAU - Ruiz-Genao, Diana P
AU  - Ruiz-Genao DP
AD  - Department of Dermatology, Hospital Universitario Fundacion Alcorcon, Madrid, 
      Spain.
FAU - Alsina, Merce
AU  - Alsina M
AD  - Department of Dermatology, Hospital Clinic de Barcelona, UB, Barcelona, Spain.
FAU - Descalzo, Miguel A
AU  - Descalzo MA
AD  - Research Unit. Fundacion Piel Sana AEDV, Madrid, Spain.
FAU - Garcia-Doval, Ignacio
AU  - Garcia-Doval I
AUID- ORCID: 0000-0002-6881-5260
AD  - Research Unit. Fundacion Piel Sana AEDV, Madrid, Spain.
AD  - Department of Dermatology, Complexo Hospitalario Universitario de Vigo, Vigo, 
      Spain.
CN  - BIOBADADERM Study Group
LA  - eng
PT  - Journal Article
DEP - 20220323
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Tumor Necrosis Factor Inhibitors)
SB  - IM
MH  - Humans
MH  - *Non-alcoholic Fatty Liver Disease/chemically induced/epidemiology
MH  - Prospective Studies
MH  - *Psoriasis/drug therapy
MH  - Registries
MH  - Tumor Necrosis Factor Inhibitors
OTO - NOTNLM
OT  - Psoriasis
OT  - adverse event
OT  - hepatic
OT  - liver
OT  - psoriasis treatment
OT  - risk
EDAT- 2021/04/30 06:00
MHDA- 2022/07/12 06:00
CRDT- 2021/04/29 12:20
PHST- 2021/04/30 06:00 [pubmed]
PHST- 2022/07/12 06:00 [medline]
PHST- 2021/04/29 12:20 [entrez]
AID - 10.1080/09546634.2021.1922572 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2022 Jun;33(4):2110-2117. doi: 10.1080/09546634.2021.1922572. 
      Epub 2022 Mar 23.