PMID- 33914148
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 188
IP  - 5
DP  - 2021 Apr 29
TI  - Core-shell MOF@COFs used as an adsorbent and matrix for the detection of 
      nonsteroidal anti-inflammatory drugs by MALDI-TOF MS.
PG  - 179
LID - 10.1007/s00604-021-04832-y [doi]
AB  - A core-shell material (UiO@TapbTp) has been developed as an adsorbent and matrix 
      to detect nonsteroidal anti-inflammatory drugs (NSAIDS) by matrix laser 
      desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in complex 
      samples. The hybrid material is prepared by growing covalent organic framework 
      (COF, TapbTp) layers in situ on an amino-modified metal-organic framework (MOF, 
      UiO-66-NH(2)). The combination of the MOF and COF overcomes their individual 
      shortcomings and integrates both of their advantages. Compared with the bare COF 
      and MOF, the core-shell composite exhibits improved enrichment ability and matrix 
      performance. With the help of pre-enrichment under optimized conditions, the 
      limits of detection (LODs) for ketoprofen, naproxen, and aspirin are reduced by 
      nearly 1000 times, with values of 0.001 mg L(-1), 0.010 mg L(-1), and 
      0.001 mg L(-1), respectively, and the relative standard deviations (RSDs) are all 
      below 12.35%. The good recoveries (84.8-118%) in (spiked) saliva and 
      environmental water sample further verify the applicability of the method in 
      complex samples.
FAU - Zheng, Ruijuan
AU  - Zheng R
AD  - Research Center for Analytical Sciences, State Key Laboratory of Medicinal 
      Chemical Biology, and Tianjin Key Laboratory of Biosensing and Molecular 
      Recognition, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 
      300071, China.
FAU - Yang, Yingchen
AU  - Yang Y
AD  - Research Center for Analytical Sciences, State Key Laboratory of Medicinal 
      Chemical Biology, and Tianjin Key Laboratory of Biosensing and Molecular 
      Recognition, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 
      300071, China.
FAU - Yang, Chang
AU  - Yang C
AD  - Research Center for Analytical Sciences, State Key Laboratory of Medicinal 
      Chemical Biology, and Tianjin Key Laboratory of Biosensing and Molecular 
      Recognition, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 
      300071, China.
FAU - Xia, Yan
AU  - Xia Y
AUID- ORCID: 0000-0002-8390-8414
AD  - Research Center for Analytical Sciences, State Key Laboratory of Medicinal 
      Chemical Biology, and Tianjin Key Laboratory of Biosensing and Molecular 
      Recognition, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 
      300071, China. nkxiayan@nankai.edu.cn.
AD  - Central Laboratory, Nankai University, Tianjin, 300071, China. 
      nkxiayan@nankai.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210429
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Drinking Water)
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (Water Pollutants, Chemical)
RN  - 57Y76R9ATQ (Naproxen)
RN  - 90Y4QC304K (Ketoprofen)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adsorption
MH  - Anti-Inflammatory Agents, Non-Steroidal/*analysis/chemistry
MH  - Aspirin/*analysis/chemistry
MH  - Drinking Water/analysis
MH  - Ketoprofen/*analysis/chemistry
MH  - Lakes/analysis
MH  - Limit of Detection
MH  - Metal-Organic Frameworks/*chemistry
MH  - Naproxen/*analysis/chemistry
MH  - Saliva/chemistry
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
MH  - Water Pollutants, Chemical/analysis/chemistry
OTO - NOTNLM
OT  - Core-shell composite
OT  - Drug pollutants
OT  - Enrichment
OT  - Nonsteroidal anti-inflammatory drugs
EDAT- 2021/04/30 06:00
MHDA- 2021/12/21 06:00
CRDT- 2021/04/29 12:29
PHST- 2021/02/09 00:00 [received]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2021/04/29 12:29 [entrez]
PHST- 2021/04/30 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
AID - 10.1007/s00604-021-04832-y [pii]
AID - 10.1007/s00604-021-04832-y [doi]
PST - epublish
SO  - Mikrochim Acta. 2021 Apr 29;188(5):179. doi: 10.1007/s00604-021-04832-y.