PMID- 33915439 OWN - NLM STAT- MEDLINE DCOM- 20210521 LR - 20220716 IS - 1878-0180 (Electronic) IS - 1751-6161 (Print) IS - 1878-0180 (Linking) VI - 119 DP - 2021 Jul TI - Three-dimensional surface strain analyses of simulated defect and augmented spine segments: A biomechanical cadaveric study. PG - 104559 LID - S1751-6161(21)00241-1 [pii] LID - 10.1016/j.jmbbm.2021.104559 [doi] AB - While several studies have investigated fracture outcomes of intact vertebrae, fracture properties in metastatically-involved and augmented vertebrae are still far from understood. Consequently, this study was aimed to use 3D digital image correlation (3D-DIC) method to investigate the failure properties of spine segments with simulated metastatic lesions, segments augmented with poly(propylene fumarate) (PPF), and compare the outcomes with intact spines. To this end, biomechanical experiments accompanied by 3D-DIC were performed on spine segments consisting of three vertebrae and two intervertebral discs (IVDs) at loading rates of 0.083 mm/s, mimicking a physiological loading condition, and 200 mm/s, mimicking an impact-type loading condition such as a fall or an accident. Full-field surface strain analysis indicated PPF augmentation reduces the superior/inferior strain when compared with the defect specimens; Presence of a defect in the middle vertebra resulted in shear band fracture pattern. Failure of the superior endplates was confirmed in several defect specimens as the superior IVDs were protruding out of defects. The augmenting PPF showed lower superior/inferior surface strain values at the fast speed as compared to the slow speed. The results of our study showed a significant increase in the fracture force from slow to fast speeds (p = 0.0246). The significance of the study was to determine the fracture properties of normal, pathological, and augmented spinal segments under physiologically-relevant loading conditions. Understanding failure properties associated with either defect (i.e., metastasis lesion) or augmented (i.e., post-treatment) spine segments could potentially provide new insights on the outcome prediction and treatment planning. Additionally, this study provides new knowledge on the effect of PPF augmentation in improving fracture properties, potentially decreasing the risk of fracture in osteoporotic and metastatic spines. CI - Copyright (c) 2021. Published by Elsevier Ltd. FAU - Rezaei, Asghar AU - Rezaei A AD - Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. FAU - Tilton, Maryam AU - Tilton M AD - Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. FAU - Giambini, Hugo AU - Giambini H AD - Department of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, San Antonio, TX, USA. FAU - Li, Yong AU - Li Y AD - Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. FAU - Hooke, Alexander AU - Hooke A AD - Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. FAU - Miller Ii, Alan L AU - Miller Ii AL AD - Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. FAU - Yaszemski, Michael J AU - Yaszemski MJ AD - Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. FAU - Lu, Lichun AU - Lu L AD - Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address: lu.lichun@mayo.edu. LA - eng GR - R01 AR056212/AR/NIAMS NIH HHS/United States GR - T32 AR056950/AR/NIAMS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20210423 PL - Netherlands TA - J Mech Behav Biomed Mater JT - Journal of the mechanical behavior of biomedical materials JID - 101322406 SB - IM MH - Biomechanical Phenomena MH - Cadaver MH - Humans MH - *Intervertebral Disc MH - Lumbar Vertebrae MH - *Spinal Fractures MH - Spine PMC - PMC8744146 MID - NIHMS1765969 OTO - NOTNLM OT - Biomechanics of vertebral bodies OT - Fracture outcomes OT - Mechanical testing OT - Metastasis OT - Vertebral augmentation EDAT- 2021/04/30 06:00 MHDA- 2021/05/22 06:00 PMCR- 2022/07/01 CRDT- 2021/04/29 20:23 PHST- 2020/11/09 00:00 [received] PHST- 2021/04/09 00:00 [revised] PHST- 2021/04/19 00:00 [accepted] PHST- 2021/04/30 06:00 [pubmed] PHST- 2021/05/22 06:00 [medline] PHST- 2021/04/29 20:23 [entrez] PHST- 2022/07/01 00:00 [pmc-release] AID - S1751-6161(21)00241-1 [pii] AID - 10.1016/j.jmbbm.2021.104559 [doi] PST - ppublish SO - J Mech Behav Biomed Mater. 2021 Jul;119:104559. doi: 10.1016/j.jmbbm.2021.104559. Epub 2021 Apr 23.