PMID- 33915480 OWN - NLM STAT- MEDLINE DCOM- 20220126 LR - 20220126 IS - 1532-3102 (Electronic) IS - 0143-4004 (Linking) VI - 109 DP - 2021 Jun TI - Salmonella Enteritidis foodborne infection induces altered placental morphometrics in the murine model. PG - 11-18 LID - S0143-4004(21)00115-6 [pii] LID - 10.1016/j.placenta.2021.04.004 [doi] AB - INTRODUCTION: Salmonella foodborne disease during pregnancy causes a significant fetal loss in domestic livestock and preterm birth, chorioamnionitis and miscarriage in humans. These complications could be associated with alterations in placental structure. This study was aimed to determine how a low dose of Salmonella Enteritidis during late gestation affects placental histomorphometric in mice. METHODS: We used a self-limiting enterocolitis murine model. BALB/c pregnant animals received a low dose of Salmonella Enteritidis (3-4 x 10(2) CFU/mouse) on gestational day (GD) 15. At day 3 post infection bacterial loads, serum cytokines expression and placental histomorphometrics parameters were analyzed. RESULTS: We found that a sub-lethal infection with Salmonella induced a significant drop in fetal weight -to-placental weight-ratio and an increase in the placental coefficient. After bacterial inoculation maternal organs were colonized, inducing placental morphometric alterations, including increased placental thickness, reduced surface area, and diminished major and minor diameters. Also, foci of necrosis accompanied by acute leukocyte infiltration in decidual zone, reduction of vascular spaces and vascular congestion in labyrinth zone, were also evident in placentas from infected females on GD 18. Our data shows that placentas from infected mothers are phenotypically different from control ones. Furthermore, expression of IFN-gamma and IL-6 was up regulated in response to Salmonella in maternal serum. DISCUSSION: Our findings demonstrate that a low dose of Salmonella during late gestation alters the placental morphometry leading to negative consequences on pregnancy outcome such as significant reduction in fetal body weight. CI - Copyright (c) 2021 Elsevier Ltd. All rights reserved. FAU - Betancourt, Diana M AU - Betancourt DM AD - Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Instituto de Investigaciones en Microbiologia y Parasitologia Medica (IMPaM-UBA-CONICET), Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, UBA, Buenos Aires, Argentina. Electronic address: dianibetancourt24@gmail.com. FAU - Llana, Mariangeles Noto AU - Llana MN AD - Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Instituto de Investigaciones en Microbiologia y Parasitologia Medica (IMPaM-UBA-CONICET), Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, UBA, Buenos Aires, Argentina. Electronic address: mnotollana@gmail.com. FAU - Sarnacki, Sebastian H AU - Sarnacki SH AD - Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Instituto de Investigaciones en Microbiologia y Parasitologia Medica (IMPaM-UBA-CONICET), Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, UBA, Buenos Aires, Argentina. Electronic address: sebasarnacki@yahoo.com.ar. FAU - Cerquetti, M Cristina AU - Cerquetti MC AD - Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Instituto de Investigaciones en Microbiologia y Parasitologia Medica (IMPaM-UBA-CONICET), Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, UBA, Buenos Aires, Argentina. Electronic address: ccerquetti@yahoo.com.ar. FAU - Monzalve, Liliana Salazar AU - Monzalve LS AD - Departamento de Morfologia, Facultad de Salud, Universidad Del Valle, Cali, Colombia. Electronic address: liliana.salazar@correounivalle.edu.co. FAU - Pustovrh, Maria C AU - Pustovrh MC AD - Departamento de Morfologia, Facultad de Salud, Universidad Del Valle, Cali, Colombia. Electronic address: maria.pustovrh@correounivalle.edu.co. FAU - Giacomodonato, Monica N AU - Giacomodonato MN AD - Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Instituto de Investigaciones en Microbiologia y Parasitologia Medica (IMPaM-UBA-CONICET), Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, UBA, Buenos Aires, Argentina. Electronic address: monicagiaco@yahoo.com.ar. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210416 PL - Netherlands TA - Placenta JT - Placenta JID - 8006349 SB - IM MH - Animals MH - Chorioamnionitis/microbiology/pathology MH - Disease Models, Animal MH - Female MH - Fetal Growth Retardation/etiology/pathology MH - Male MH - Mice MH - Mice, Inbred BALB C MH - Placenta/microbiology/*pathology MH - Placenta Diseases/microbiology/pathology MH - Pregnancy MH - Pregnancy Complications, Infectious/microbiology/*pathology MH - Salmonella Food Poisoning/complications/pathology MH - Salmonella Infections/complications/*pathology MH - Salmonella enteritidis/*physiology MH - Systemic Inflammatory Response Syndrome/complications/microbiology/pathology OTO - NOTNLM OT - Foodborne diseases OT - Placenta OT - Placental morphometry OT - Pregnancy OT - Salmonella Enteritidis EDAT- 2021/04/30 06:00 MHDA- 2022/01/27 06:00 CRDT- 2021/04/29 20:25 PHST- 2021/03/16 00:00 [received] PHST- 2021/04/06 00:00 [accepted] PHST- 2021/04/30 06:00 [pubmed] PHST- 2022/01/27 06:00 [medline] PHST- 2021/04/29 20:25 [entrez] AID - S0143-4004(21)00115-6 [pii] AID - 10.1016/j.placenta.2021.04.004 [doi] PST - ppublish SO - Placenta. 2021 Jun;109:11-18. doi: 10.1016/j.placenta.2021.04.004. Epub 2021 Apr 16.