PMID- 33915654
OWN - NLM
STAT- MEDLINE
DCOM- 20210503
LR  - 20210503
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 50
IP  - 5
DP  - 2021 May 8
TI  - [Nodular fasciitis of the breast: a clinicopathological and genetic analysis of 
      seven cases].
PG  - 476-481
LID - 10.3760/cma.j.cn112151-20201230-00989 [doi]
AB  - Objective: To investigate the clinicopathological and genetic features of nodular 
      fasciitis of the breast (NFB). Methods: The clinical and histologic features of 
      seven NFBs were retrospectively reviewed. Immunohistochemistry, fluorescence in 
      situ hybridization (FISH) and reverse transcription-polymerase chain reaction 
      (RT-PCR) were performed. Results: All the seven patients were female, with a mean 
      age of 36 years (range from 15 to 51 years). The duration of the lesion ranged 
      from 10 days to 2 years. There was no history of trauma for all patients. The 
      lesions occurred in the upper quadrant (4 cases), the lower quadrant (2 cases) 
      and the axillary tail region (1 case). The maximum diameter was 1.0-3.5 cm. All 
      cases showed similar morphology as nodular fasciitis occurring elsewhere in the 
      body. They were composed of plump spindle cells arranged in short bundles or 
      fascicles within a loose collagenous/myxoid stroma. Erythrocyte extravasation, 
      mixed chronic inflammatory cells infiltration and microcystic changes were 
      typically seen. Mitoses were present, with no atypical mitoses observed. The 
      spindle cells were positive for smooth muscleactin(SMA, 6/6), CD10(2/3), and 
      negative for desmin, beta-catenin, CD34, CKpan, EMA, S-100, p63 and ALK-1.The Ki-67 
      index were 5%-15%. USP6 gene rearrangement was found in six cases and MYH9-USP6 
      gene fusion in two cases. Local resection was performed in six cases. Spontaneous 
      regression was observed in one case. Follow-up of all seven cases revealed no 
      recurrence or metastasis. Conclusions: Although rare, NFB can mimic breast cancer 
      clinically, radiologically and histologically. It should be always considered in 
      the differential diagnosis for the spindle cell proliferations of the breast. A 
      diagnosis of NFB can be achieved basing on the typical clinicopathological 
      presentation. FISH detection of USP6 gene rearrangement in challenging cases is 
      of great value.
FAU - Zhang, Y H
AU  - Zhang YH
AD  - Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
FAU - Qiu, Y
AU  - Qiu Y
AD  - Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
FAU - Zhang, Z
AU  - Zhang Z
AD  - Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
FAU - Chen, H J
AU  - Chen HJ
AD  - Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
FAU - Zhang, H Y
AU  - Zhang HY
AD  - Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
LA  - chi
GR  - 81972520/National Natural Science Foundation of China/
GR  - 2020YFS0270/Sichuan Science and Technology Program/
GR  - 2018HXFH011/The 1.3.5 Project for Disciplines of Excellence-Clinical Research 
      Incubation Project, West China Hospital, Sichuan University/
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Fasciitis/genetics
MH  - Female
MH  - *Fibroma
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Ubiquitin Thiolesterase
MH  - Young Adult
EDAT- 2021/04/30 06:00
MHDA- 2021/05/04 06:00
CRDT- 2021/04/29 22:54
PHST- 2021/04/29 22:54 [entrez]
PHST- 2021/04/30 06:00 [pubmed]
PHST- 2021/05/04 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20201230-00989 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2021 May 8;50(5):476-481. doi: 
      10.3760/cma.j.cn112151-20201230-00989.