PMID- 33916411
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210502
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 7
DP  - 2021 Apr 5
TI  - Prevalence of Circadian Rhythm Sleep-Wake Disorder in Outpatients with 
      Schizophrenia and Its Association with Psychopathological Characteristics and 
      Psychosocial Functioning.
LID - 10.3390/jcm10071513 [doi]
LID - 1513
AB  - The prevalence of circadian rhythm sleep-wake disorder (CRSWD) among patients 
      with schizophrenia is not clear. The effect of comorbid CRSWD on such patients 
      has also not been fully evaluated yet. Outpatients with schizophrenia in the 
      maintenance phase who visited Tokyo Women's Medical University Hospital between 
      April 2018 and March 2019 participated in this study. The Brief Psychiatric 
      Rating Scale (BPRS), the Clinical Global Impressions-Severity Illness Scale 
      (CGI-S), Global Assessment of Functioning (GAF), World Health Organization 
      Disability Assessment Schedule II, Insomnia Severity Index (ISI), and 
      Morningness-Eveningness Questionnaire (MEQ) were administered, and the patient 
      responses with and without CRSWD were compared. Of the 105 patients with 
      schizophrenia, 19 (18.1%) had CRSWD. There were trends toward higher BPRS and 
      lower GAF scores in the CRSWD group than in the non-CRSWD group, although these 
      did not reach statistical significance following a false discovery rate 
      correction. Among the BPRS subitems, the anxiety scores were significantly higher 
      in the CRSWD group than in the non-CRSWD group (p < 0.01). CRSWD was highly 
      prevalent among patients with schizophrenia in the maintenance phase. 
      Comorbidities of CRSWD may affect psychopathological characteristics and 
      psychosocial functioning.
FAU - Matsui, Kentaro
AU  - Matsui K
AD  - Department of Psychiatry, Tokyo Women's Medical University, Tokyo 1628666, Japan.
AD  - Clinical Laboratory, National Institute of Mental Health, National Center of 
      Neurology and Psychiatry, Tokyo 1878551, Japan.
AD  - Department of Sleep-Wake Disorders, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, Tokyo 1878551, Japan.
FAU - Inada, Ken
AU  - Inada K
AD  - Department of Psychiatry, Tokyo Women's Medical University, Tokyo 1628666, Japan.
FAU - Kuriyama, Kenichi
AU  - Kuriyama K
AUID- ORCID: 0000-0002-0254-4357
AD  - Department of Sleep-Wake Disorders, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, Tokyo 1878551, Japan.
FAU - Yoshiike, Takuya
AU  - Yoshiike T
AUID- ORCID: 0000-0002-6071-8167
AD  - Department of Sleep-Wake Disorders, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, Tokyo 1878551, Japan.
FAU - Nagao, Kentaro
AU  - Nagao K
AD  - Department of Sleep-Wake Disorders, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, Tokyo 1878551, Japan.
FAU - Oshibuchi, Hidehiro
AU  - Oshibuchi H
AD  - Department of Psychiatry, Tokyo Women's Medical University, Tokyo 1628666, Japan.
FAU - Akaho, Rie
AU  - Akaho R
AD  - Department of Psychiatry, Tokyo Women's Medical University, Tokyo 1628666, Japan.
FAU - Nishimura, Katsuji
AU  - Nishimura K
AD  - Department of Psychiatry, Tokyo Women's Medical University, Tokyo 1628666, Japan.
LA  - eng
GR  - 19K17098/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20210405
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8038557
OTO - NOTNLM
OT  - anxiety
OT  - circadian rhythm
OT  - schizophrenia
OT  - sleep-wake cycle
OT  - social dysfunction
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/05
CRDT- 2021/04/30 01:03
PHST- 2021/01/08 00:00 [received]
PHST- 2021/03/10 00:00 [revised]
PHST- 2021/03/23 00:00 [accepted]
PHST- 2021/04/30 01:03 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/05 00:00 [pmc-release]
AID - jcm10071513 [pii]
AID - jcm-10-01513 [pii]
AID - 10.3390/jcm10071513 [doi]
PST - epublish
SO  - J Clin Med. 2021 Apr 5;10(7):1513. doi: 10.3390/jcm10071513.