PMID- 33916997
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210502
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 9
IP  - 4
DP  - 2021 Apr 7
TI  - Recent Advances in PRRS Virus Receptors and the Targeting of Receptor-Ligand for 
      Control.
LID - 10.3390/vaccines9040354 [doi]
LID - 354
AB  - Cellular receptors play a critical role in viral infection. At least seven 
      cellular molecules have been identified as putative viral entry mediators for 
      porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data 
      indicate that among these candidates, CD163, a cysteine-rich scavenger receptor 
      on macrophages, is the major receptor for PRRSV. This review discusses the recent 
      advances and understanding of the entry of PRRSV into cells, viral pathogenesis 
      in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand 
      for the control of PRRS.
FAU - Su, Chia-Ming
AU  - Su CM
AUID- ORCID: 0000-0001-9317-5886
AD  - Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, 
      IL 61802, USA.
FAU - Rowland, Raymond Robert Richard
AU  - Rowland RRR
AD  - Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, 
      IL 61802, USA.
FAU - Yoo, Dongwan
AU  - Yoo D
AUID- ORCID: 0000-0002-6730-9729
AD  - Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, 
      IL 61802, USA.
LA  - eng
GR  - 2018-67015-28287/National Institute of Food and Agriculture/
GR  - 2016-09462, 2017-2021/National Institute of Food and Agriculture/
PT  - Journal Article
PT  - Review
DEP - 20210407
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC8067724
OTO - NOTNLM
OT  - CD163
OT  - PRRSV
OT  - porcine reproductive and respiratory syndrome
OT  - receptor
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/07
CRDT- 2021/04/30 01:05
PHST- 2021/03/13 00:00 [received]
PHST- 2021/04/02 00:00 [revised]
PHST- 2021/04/05 00:00 [accepted]
PHST- 2021/04/30 01:05 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/07 00:00 [pmc-release]
AID - vaccines9040354 [pii]
AID - vaccines-09-00354 [pii]
AID - 10.3390/vaccines9040354 [doi]
PST - epublish
SO  - Vaccines (Basel). 2021 Apr 7;9(4):354. doi: 10.3390/vaccines9040354.