PMID- 33917480
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210502
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 13
IP  - 7
DP  - 2021 Apr 6
TI  - Effects of Epstein-Barr Virus Infection on the Risk and Prognosis of Primary 
      Laryngeal Squamous Cell Carcinoma: A Hospital-Based Case-Control Study in Taiwan.
LID - 10.3390/cancers13071741 [doi]
LID - 1741
AB  - Mounting molecular evidence supports Epstein-Barr virus (EBV) involvement in the 
      pathogenesis of laryngeal squamous cell carcinoma (LSCC); however, the 
      epidemiological data are inconsistent. In this retrospective case-control study, 
      we aimed to determine whether EBV infection underlies the risk and prognosis of 
      LSCC. The prevalence of EBV infection, as analyzed using an EBV DNA polymerase 
      chain reaction assay, was significantly higher in 42 Taiwanese patients with 
      newly diagnosed primary LSCC, compared to 39 age- and sex-matched control 
      patients without cancer (48% vs. 19%). Furthermore, most of the EBER signals 
      detected using in situ hybridization were localized to the nuclei of 
      tumor-infiltrating lymphocytes. In multivariate analysis, EBV DNA positivity, age 
      >/= 55 years, cigarette smoking, and high BCL-2, B2M, and CD161 expression 
      (assessed using immunohistochemistry) were identified as independent risk factors 
      for LSCC. Furthermore, five-year local recurrence and disease-free survival rates 
      were 34% and 58%, respectively, with a high EBER signal and low CD3 expression 
      independently predicting five-year local recurrence and disease-free survival. 
      Our comprehensive profiling data accurately identified patients at risk for LSCC 
      development, local recurrence, or disease-free survival. The information obtained 
      in this study improves our understanding of EBV infection in LSCC, and may guide 
      precision medicine for patients with LSCC.
FAU - Lee, Li-Ang
AU  - Lee LA
AUID- ORCID: 0000-0001-8414-595X
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial 
      Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Fang, Tuan-Jen
AU  - Fang TJ
AUID- ORCID: 0000-0002-7805-3458
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial 
      Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Li, Hsueh-Yu
AU  - Li HY
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial 
      Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Chuang, Hai-Hua
AU  - Chuang HH
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
AD  - Department of Family Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, 
      Taoyuan 33305, Taiwan.
AD  - Department of Industrial Engineering and Management, National Taipei University 
      of Technology, Taipei 10608, Taiwan.
FAU - Kang, Chung-Jan
AU  - Kang CJ
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial 
      Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Chang, Kai-Ping
AU  - Chang KP
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial 
      Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Liao, Chun-Ta
AU  - Liao CT
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial 
      Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Chen, Tse-Ching
AU  - Chen TC
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
AD  - Department of Pathology, Chang Gung Memorial Hospital, Linkou Main Branch, 
      Taoyuan City 33305, Taiwan.
FAU - Huang, Chung-Guei
AU  - Huang CG
AD  - Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main 
      Branch, Taoyuan City 33305, Taiwan.
AD  - Research Center for Emerging Viral Infections, Graduate Institute of Biomedical 
      Sciences, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Yen, Tzu-Chen
AU  - Yen TC
AD  - Faculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
AD  - Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial 
      Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
LA  - eng
GR  - 3C0661, 3C0662, 3C0663, and 3F1092/Chang Gung Medical Foundation/
PT  - Journal Article
DEP - 20210406
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8038767
OTO - NOTNLM
OT  - B2M
OT  - BCL-2
OT  - CD161
OT  - CD3
OT  - EBER
OT  - Epstein-Barr virus
OT  - disease-free survival
OT  - laryngeal squamous cell carcinoma
OT  - local recurrence
OT  - risk
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/06
CRDT- 2021/04/30 01:06
PHST- 2021/03/16 00:00 [received]
PHST- 2021/04/01 00:00 [revised]
PHST- 2021/04/01 00:00 [accepted]
PHST- 2021/04/30 01:06 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/06 00:00 [pmc-release]
AID - cancers13071741 [pii]
AID - cancers-13-01741 [pii]
AID - 10.3390/cancers13071741 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Apr 6;13(7):1741. doi: 10.3390/cancers13071741.