PMID- 33919161
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210526
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 9
IP  - 5
DP  - 2021 Apr 21
TI  - Correlation of Neutralizing Antibodies (NAbs) between Sows and Piglets and 
      Evaluation of Protectability Associated with Maternally Derived NAbs in Pigs 
      against Circulating Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) 
      under Field Conditions.
LID - 10.3390/vaccines9050414 [doi]
LID - 414
AB  - Porcine reproductive and respiratory syndrome (PRRS), which is caused by a highly 
      transmissible pathogen called porcine reproductive and respiratory syndrome virus 
      (PRRSV), has caused severe problems, including reproductive disorders in sows and 
      respiratory symptoms in nursery pigs worldwide, since the early 1990s. However, 
      currently available PRRSV vaccines do not supply complete immunity to confront 
      the viral infection. Elicitation of PRRSV-specific neutralizing antibodies (NAbs) 
      during the preinfectious period has been deemed to be a feasible strategy to 
      modulate this virus, especially in farms where nursery pigs are seized with 
      PRRSVs. A total of 180 piglets in a farrow-to-finish farm that had a natural 
      outbreak of PRRS were distributed into three groups based on the different PRRSV 
      NAbs levels in their dams. In the present study, piglets that received superior 
      maternal-transferred NAbs showed delayed and relatively slight viral loads in 
      serum and, on the whole, higher survival rates against wild PRRSV infections. A 
      positive correlation of maternal NAbs between sows and their piglets was 
      identified; moreover, high NAbs titers in piglets can last for at least 4 weeks. 
      These results provide updated information to develop an appropriate immune 
      strategy for breeding and for future PRRSV control under field conditions.
FAU - Hsueh, Fu-Chun
AU  - Hsueh FC
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Wang, Sheng-Yuan
AU  - Wang SY
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Lin, Wei-Hao
AU  - Lin WH
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Lin, Chuen-Fu
AU  - Lin CF
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Tsai, Chen-Yu
AU  - Tsai CY
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Huang, Chin-Wen
AU  - Huang CW
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Sun, Ning
AU  - Sun N
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Chiou, Ming-Tang
AU  - Chiou MT
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Lin, Chao-Nan
AU  - Lin CN
AUID- ORCID: 0000-0003-1911-7535
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
LA  - eng
GR  - MOST 325 109-2313-B-020-004/Ministry of Science and Technology, Taiwan/
PT  - Journal Article
DEP - 20210421
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC8143086
OTO - NOTNLM
OT  - correlates of protections
OT  - field experiment
OT  - maternal neutralizing antibody
OT  - porcine reproductive and respiratory syndrome virus
OT  - survival rate
OT  - viral load
COIS- The authors declare no conflict of interest with respect to the research, 
      authorship, and/or publication of this article.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/21
CRDT- 2021/04/30 01:11
PHST- 2021/03/26 00:00 [received]
PHST- 2021/04/19 00:00 [revised]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2021/04/30 01:11 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/21 00:00 [pmc-release]
AID - vaccines9050414 [pii]
AID - vaccines-09-00414 [pii]
AID - 10.3390/vaccines9050414 [doi]
PST - epublish
SO  - Vaccines (Basel). 2021 Apr 21;9(5):414. doi: 10.3390/vaccines9050414.