PMID- 33919505
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 11
IP  - 4
DP  - 2021 Apr 18
TI  - Serous Carcinoma of the Endometrium with Mesonephric-Like Differentiation 
      Initially Misdiagnosed as Uterine Mesonephric-Like Adenocarcinoma: A Case Report 
      with Emphasis on the Immunostaining and the Identification of Splice Site TP53 
      Mutation.
LID - 10.3390/diagnostics11040717 [doi]
LID - 717
AB  - We present herein a rare case of uterine serous carcinoma with mesonephric-like 
      differentiation (SC-MLD) initially misdiagnosed as mesonephric-like 
      adenocarcinoma (MLA). A 51-year-old woman underwent total hysterectomy for a 
      uterine tumor. Histologically, the tumor exhibited various architectures, 
      including papillary, glandular, tubular, cribriform, and cystic. On the basis of 
      this architectural diversity accompanied by intraluminal eosinophilic secretions 
      and intermediate-grade nuclear atypia, the initial diagnosis was MLA. However, 
      the tumor was diffusely and strongly positive for the expression of p16 and 
      negative for the expression of GATA-binding protein 3 (GATA3). Furthermore, we 
      identified a pathogenic tumor protein 53 (TP53) mutation affecting an acceptor 
      splice site in intron 9, despite a wild-type p53 immunostaining pattern. The 
      observations of diffuse and strong p16 expression, lack of GATA3 expression, 
      pathogenic TP53 mutation, and wild-type Kirsten rat sarcoma viral oncogene 
      homolog indicate that this tumor was not an MLA but an SC-MLD. Both uterine SC 
      and MLA can exhibit various histological growth patterns. Our comprehensive 
      clinicopathological and molecular analyses can serve to improve the understanding 
      of this rare condition and help pathologists in making an accurate diagnosis.
FAU - Choi, Sangjoon
AU  - Choi S
AD  - Department of Pathology and Translational Genomics, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
FAU - Jung, Yoon Yang
AU  - Jung YY
AUID- ORCID: 0000-0001-9905-3900
AD  - Department of Pathology, Myongji Hospital, Hanyang University College of 
      Medicine, Goyang-si 10475, Gyeonggi-do, Korea.
FAU - Kim, Hyun-Soo
AU  - Kim HS
AUID- ORCID: 0000-0003-4730-221X
AD  - Department of Pathology and Translational Genomics, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
LA  - eng
PT  - Case Reports
DEP - 20210418
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC8073336
OTO - NOTNLM
OT  - TP53 mutation
OT  - endometrium
OT  - mesonephric-like adenocarcinoma
OT  - serous carcinoma
OT  - uterus
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/18
CRDT- 2021/04/30 01:12
PHST- 2021/02/20 00:00 [received]
PHST- 2021/04/02 00:00 [revised]
PHST- 2021/04/15 00:00 [accepted]
PHST- 2021/04/30 01:12 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/18 00:00 [pmc-release]
AID - diagnostics11040717 [pii]
AID - diagnostics-11-00717 [pii]
AID - 10.3390/diagnostics11040717 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2021 Apr 18;11(4):717. doi: 10.3390/diagnostics11040717.