PMID- 33919513
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 4
DP  - 2021 Apr 18
TI  - Correlations between Coffee Consumption and Metabolic Phenotypes, Plasma Folate, 
      and Vitamin B12: NHANES 2003 to 2006.
LID - 10.3390/nu13041348 [doi]
LID - 1348
AB  - Metabolic syndrome (MetS) is prevalent not only among the overweight and obese 
      but also normal weight individuals, and the phenotype is referred to as a 
      metabolically unhealthy phenotype (MUHP). Besides normal weight individuals, 
      overweight/obese individuals are also protected from MetS, and the phenotype is 
      known as a metabolically healthy phenotype (MHP). Epidemiological studies 
      indicate that coffee and micronutrients such as plasma folate or vitamin B12 
      (vit. B12) are inversely associated with MetS. However, correlations among coffee 
      consumption metabolic phenotypes, plasma folate, and vit. B12 remain unknown. Our 
      objective was to investigate the correlation between coffee consumption, 
      metabolic phenotypes, plasma folate, and vit. B12 as well as to understand 
      associations between plasma folate, vit. B12, and metabolic phenotypes. 
      Associations among coffee consumption metabolic phenotypes, plasma folate, and 
      vit. B12 were assessed in a cross-sectional study of 2201 participants, 18 years 
      or older, from 2003-2004 and 2005-2006 National Health and Nutrition Examination 
      Surveys (NHANES). MUHP was classified as having > three metabolic abnormalities. 
      Coffee consumption was not associated with metabolic phenotypes, but negatively 
      correlated with several metabolic variables, including BMI (p < 0.001). Plasma 
      folate was positively associated with MUHP (p < 0.004), while vit. B12 was 
      inversely associated with MUHP (p < 0.035). Our results suggest the potential 
      protective impact of coffee on individual components of MetS and indicate a 
      positive correlation between coffee consumption and MUHP among overweight 
      individuals. Identifying possible dietary factors may provide practical and 
      low-cost dietary intervention targets, specifically for early intervention. 
      Larger and randomized intervention studies and prospective longitudinal studies 
      are required to further evaluate these associations.
FAU - Nerurkar, Pratibha V
AU  - Nerurkar PV
AD  - Laboratory of Metabolic Disorders and Alternative Medicine, Department of 
      Molecular Biosciences and Bioengineering (MBBE), College of Tropical Agriculture 
      and Human Resources (CTAHR), University of Hawaii at Manoa, Honolulu, HI 96822, 
      USA.
FAU - Gandhi, Krupa
AU  - Gandhi K
AD  - Division of Biostatistics, Thomas Jefferson University Hospitals, Philadelphia, 
      PA 19107, USA.
FAU - Chen, John J
AU  - Chen JJ
AD  - Department of Quantitative Health Sciences, John A. Burns School of Medicine, 
      University of Hawaii at Manoa, Honolulu, HI 96813, USA.
LA  - eng
GR  - HAW05023-R, HAW00598-H, W3122, W4122, HAW00526-H, 2004-34135-15182/Agriculture 
      and Food Research Initiative - National Institute of Food and Agriculture, USDA/
PT  - Journal Article
DEP - 20210418
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Coffee)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Mass Index
MH  - Cardiometabolic Risk Factors
MH  - *Coffee
MH  - Cross-Sectional Studies
MH  - Drinking/*physiology
MH  - Female
MH  - Folic Acid/*blood
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/blood/*etiology
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Obesity/blood/complications
MH  - Overweight/blood/complications
MH  - Phenotype
MH  - Protective Factors
MH  - Vitamin B 12/*blood
MH  - Young Adult
PMC - PMC8073624
OTO - NOTNLM
OT  - coffee
OT  - metabolic healthy obesity
OT  - metabolically healthy phenotype
OT  - metabolically unhealthy phenotypes
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/29 06:00
PMCR- 2021/04/18
CRDT- 2021/04/30 01:12
PHST- 2021/03/28 00:00 [received]
PHST- 2021/04/12 00:00 [revised]
PHST- 2021/04/15 00:00 [accepted]
PHST- 2021/04/30 01:12 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2021/04/18 00:00 [pmc-release]
AID - nu13041348 [pii]
AID - nutrients-13-01348 [pii]
AID - 10.3390/nu13041348 [doi]
PST - epublish
SO  - Nutrients. 2021 Apr 18;13(4):1348. doi: 10.3390/nu13041348.