PMID- 33919529
OWN - NLM
STAT- MEDLINE
DCOM- 20210524
LR  - 20221207
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 8
DP  - 2021 Apr 18
TI  - Physical Activity and Glycemic Control Status in Chinese Patients with Type 2 
      Diabetes: A Secondary Analysis of a Randomized Controlled Trial.
LID - 10.3390/ijerph18084292 [doi]
LID - 4292
AB  - This secondary analysis was designed to evaluate the independent effect of 
      physical activity (PA) on hemoglobin A1c (HbA1c) level in Chinese patients with 
      type 2 diabetes mellitus (T2DM). A total of 799 T2DM patients from eight 
      communities of Shanghai, China, were randomized into one control arm and three 
      intervention arms receiving 1-year interventions of health literacy, exercise, or 
      both. PA was measured using the International Physical Activity Questionnaire at 
      baseline, 12 months, and 24 months and quantified as metabolic equivalents 
      (Mets). A multiple level mixed regression model was applied to evaluate the 
      associations between PA and HbA1c level. After adjusting for potential 
      confounders including interaction of PA level with initial PA or HbA1c, a 
      significant improved HbA1c was observed for the patients in the medium versus the 
      lowest tertile groups of overall PA at 12 months (beta: -3.47, 95%CI: -5.33, -1.60) 
      and for those in the highest versus the lowest tertile group at 24 months (beta: 
      -0.50, 95%CI: -1.00, -0.01), resulting in a beta (95%CI) of -3.49 (95%CI: -5.87, 
      -1.11) during the whole two-year period of follow-up. The negative association 
      was also observed when the subjects were classified according to their exercise 
      levels using the World Health Organization (WHO) recommendation as a cut-off 
      point. The beneficial effect of higher PA level was only observed among patients 
      having a lower level of baseline HbA1c or PA or both (all p values for 
      interaction <0.05). Our results provide evidence for the beneficial effect of PA 
      and suggest that the exercise intervention should be addressed to the physically 
      inactive patients to improve their PA level to a physiological threshold.
FAU - Yao, Wei-Yuan
AU  - Yao WY
AD  - Key Laboratory of Public Health Safety (Ministry of Health), School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Han, Meng-Ge
AU  - Han MG
AD  - Key Laboratory of Public Health Safety (Ministry of Health), School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - De Vito, Giuseppe
AU  - De Vito G
AUID- ORCID: 0000-0002-6855-9180
AD  - Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
FAU - Fang, Hong
AU  - Fang H
AD  - Minhang District Center for Disease Control and Prevention, Shanghai 201102, 
      China.
FAU - Xia, Qinghua
AU  - Xia Q
AD  - Changning District Center for Disease Control and Prevention, Shanghai 200051, 
      China.
FAU - Chen, Yingyao
AU  - Chen Y
AD  - Key Laboratory of Health Technology Assessment (National Health Commission), 
      School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Liu, Xiaona
AU  - Liu X
AD  - Key Laboratory of Public Health Safety (Ministry of Health), School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Wei, Yan
AU  - Wei Y
AD  - Key Laboratory of Public Health Safety (Ministry of Health), School of Public 
      Health, Fudan University, Shanghai 200032, China.
AD  - Key Laboratory of Health Technology Assessment (National Health Commission), 
      School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Rothman, Russell L
AU  - Rothman RL
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 
      37232, USA.
FAU - Xu, Wang-Hong
AU  - Xu WH
AUID- ORCID: 0000-0003-2045-2218
AD  - Key Laboratory of Public Health Safety (Ministry of Health), School of Public 
      Health, Fudan University, Shanghai 200032, China.
AD  - Key Laboratory of Health Technology Assessment (National Health Commission), 
      School of Public Health, Fudan University, Shanghai 200032, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20210418
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Blood Glucose
MH  - China
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Exercise
MH  - Glycated Hemoglobin/analysis
MH  - Glycemic Control
MH  - Humans
PMC - PMC8073010
OTO - NOTNLM
OT  - glycemic control
OT  - physical activity
OT  - randomized control trial
OT  - type 2 diabetes
COIS- The authors declare that they have no competing interests.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/25 06:00
PMCR- 2021/04/18
CRDT- 2021/04/30 01:12
PHST- 2021/02/26 00:00 [received]
PHST- 2021/04/07 00:00 [revised]
PHST- 2021/04/09 00:00 [accepted]
PHST- 2021/04/30 01:12 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/25 06:00 [medline]
PHST- 2021/04/18 00:00 [pmc-release]
AID - ijerph18084292 [pii]
AID - ijerph-18-04292 [pii]
AID - 10.3390/ijerph18084292 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Apr 18;18(8):4292. doi: 
      10.3390/ijerph18084292.