PMID- 33919875
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 11
IP  - 4
DP  - 2021 Apr 14
TI  - Dendritic Cells Are Associated with Prognosis and Survival in Breast Cancer.
LID - 10.3390/diagnostics11040702 [doi]
LID - 702
AB  - Dendritic cells (DCs) constitute a part of the tumour microenvironment, but we 
      are still far from understanding their complex role in immune response to the 
      tumour. This study aimed to investigate the density of DCs expressing CD1a, CD83, 
      CD123, DC-LAMP3 (CD208) and DC-SIGN (CD209) in breast cancer. The correlations 
      between DC density and molecular subtype of breast cancer, its hormone receptor 
      status, spatial location and their associations with clinical and pathological 
      prognostic factors were evaluated. We have shown that intratumoural CD1a+ cells 
      were significantly associated with progression-free survival. For LAMP3+ and 
      CD123+ DCs, higher cell densities were associated with non-luminal as compared to 
      luminal cancer phenotype. In contrast, dense CD83+ DC infiltrate was observed in 
      luminal tumours. The number of CD1a+ DCs in both locations was the highest in 
      luminal B/HER2+ cancers. The highest positive cell count of LAMP3+ cells was 
      observed in the triple-negative subtype in both locations. We found higher 
      numbers of LAMP3+ DCs both intratumourally and at the invasive margin, as well as 
      CD123+ DCs intratumourally in tumours with negative expression of oestrogen or 
      progesterone receptors. Our study demonstrates associations between DC 
      subpopulations and histological and clinical characteristics, as well as 
      molecular subtypes in breast carcinoma.
FAU - Szpor, Joanna
AU  - Szpor J
AUID- ORCID: 0000-0002-1267-6257
AD  - Department of Pathomorphology, Jagiellonian University Medical College, 31-531 
      Krakow, Poland.
FAU - Streb, Joanna
AU  - Streb J
AD  - Department of Oncology, Jagiellonian University Medical College, 31-531 Krakow, 
      Poland.
FAU - Glajcar, Anna
AU  - Glajcar A
AD  - Department of Pathomorphology, Jagiellonian University Medical College, 31-531 
      Krakow, Poland.
FAU - Fraczek, Paulina
AU  - Fraczek P
AD  - Department of Oncology, Jagiellonian University Medical College, 31-531 Krakow, 
      Poland.
FAU - Winiarska, Aleksandra
AU  - Winiarska A
AUID- ORCID: 0000-0002-5819-8414
AD  - Department of Pathomorphology, Jagiellonian University Medical College, 31-531 
      Krakow, Poland.
FAU - Tyrak, Katarzyna E
AU  - Tyrak KE
AD  - Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 
      31-066 Krakow, Poland.
FAU - Basta, Pawel
AU  - Basta P
AD  - Department of Gynecology and Oncology, Jagiellonian University Medical College, 
      31-501 Krakow, Poland.
FAU - Okon, Krzysztof
AU  - Okon K
AUID- ORCID: 0000-0002-1921-5007
AD  - Department of Pathomorphology, Jagiellonian University Medical College, 31-531 
      Krakow, Poland.
FAU - Jach, Robert
AU  - Jach R
AUID- ORCID: 0000-0001-5512-763X
AD  - Department of Gynecology and Oncology, Jagiellonian University Medical College, 
      31-501 Krakow, Poland.
FAU - Hodorowicz-Zaniewska, Diana
AU  - Hodorowicz-Zaniewska D
AD  - General, Oncological, and Gastrointestinal Surgery, Jagiellonian University 
      Medical College, 30-688 Krakow, Poland.
LA  - eng
PT  - Journal Article
DEP - 20210414
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC8070803
OTO - NOTNLM
OT  - breast cancer
OT  - dendritic cells
OT  - molecular subtype
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/14
CRDT- 2021/04/30 01:13
PHST- 2021/03/08 00:00 [received]
PHST- 2021/03/24 00:00 [revised]
PHST- 2021/03/29 00:00 [accepted]
PHST- 2021/04/30 01:13 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/14 00:00 [pmc-release]
AID - diagnostics11040702 [pii]
AID - diagnostics-11-00702 [pii]
AID - 10.3390/diagnostics11040702 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2021 Apr 14;11(4):702. doi: 10.3390/diagnostics11040702.