PMID- 33919949
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20221207
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 11
IP  - 4
DP  - 2021 Apr 14
TI  - EndoBarrier Implantation Rapidly Improves Insulin Sensitivity in Obese 
      Individuals with Type 2 Diabetes Mellitus.
LID - 10.3390/biom11040574 [doi]
LID - 574
AB  - The EndoBarrier medical device is a duodenal-jejunal bypass liner designed to 
      mimic the effects of gastric bypass surgery to induce weight loss and glycaemic 
      improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM), 
      a mean body mass index (BMI) of 43.3 +/- 5.0 (kg/m(2)) and a mean glycated 
      haemoglobin A1c (HbA1c) of 60.6 +/- 8.6 mmol/mol were examined at baseline (before 
      implantation of EndoBarrier), 4 weeks after implantation, at 36 weeks (right 
      before explantation) and 24 weeks after the removal of the device to explore the 
      short and long-term effects on glucose metabolism. Besides a significant 
      reduction in body weight and fat mass, EndoBarrier treatment significantly 
      improved insulin sensitivity during Botnia clamp investigations after four weeks 
      of implantation. The beneficial effects decreased over time but remained 
      significant 24 weeks after removal of the device.
FAU - Obermayer, Anna
AU  - Obermayer A
AUID- ORCID: 0000-0002-7663-0426
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
FAU - Tripolt, Norbert J
AU  - Tripolt NJ
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
FAU - Aziz, Faisal
AU  - Aziz F
AUID- ORCID: 0000-0002-0109-2969
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
FAU - Hogenauer, Christoph
AU  - Hogenauer C
AUID- ORCID: 0000-0003-4566-0806
AD  - Division of Gastroenterology and Hepatology, Medical University of Graz, 8010 
      Graz, Austria.
FAU - Aberer, Felix
AU  - Aberer F
AUID- ORCID: 0000-0002-9947-1413
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
FAU - Schreiber, Florian
AU  - Schreiber F
AD  - Division of Gastroenterology and Hepatology, Medical University of Graz, 8010 
      Graz, Austria.
FAU - Eherer, Andreas
AU  - Eherer A
AD  - Division of Gastroenterology and Hepatology, Medical University of Graz, 8010 
      Graz, Austria.
FAU - Sourij, Caren
AU  - Sourij C
AD  - Department of Internal Medicine, Division of Cardiology, Medical University of 
      Graz, 8010 Graz, Austria.
FAU - Stadlbauer, Vanessa
AU  - Stadlbauer V
AUID- ORCID: 0000-0001-5508-8271
AD  - Division of Gastroenterology and Hepatology, Medical University of Graz, 8010 
      Graz, Austria.
AD  - CBmed-Center for Biomarker Research in Medicine, 8010 Graz, Austria.
FAU - Svehlikova, Eva
AU  - Svehlikova E
AUID- ORCID: 0000-0002-9743-2031
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
AD  - CRC-Clinical Research Center, Medical University of Graz, 8010 Graz, Austria.
FAU - Brunner, Martina
AU  - Brunner M
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
AD  - CRC-Clinical Research Center, Medical University of Graz, 8010 Graz, Austria.
FAU - Goswami, Nandu
AU  - Goswami N
AUID- ORCID: 0000-0002-6704-0723
AD  - Otto Loewi Research Centre, Physiology Division, Medical University of Graz, 8010 
      Graz, Austria.
FAU - Kojzar, Harald
AU  - Kojzar H
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
FAU - Pferschy, Peter N
AU  - Pferschy PN
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
AD  - CBmed-Center for Biomarker Research in Medicine, 8010 Graz, Austria.
FAU - Pieber, Thomas R
AU  - Pieber TR
AUID- ORCID: 0000-0003-3554-0405
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
AD  - CBmed-Center for Biomarker Research in Medicine, 8010 Graz, Austria.
FAU - Sourij, Harald
AU  - Sourij H
AUID- ORCID: 0000-0003-3510-9594
AD  - Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, 
      Austria.
AD  - CBmed-Center for Biomarker Research in Medicine, 8010 Graz, Austria.
LA  - eng
PT  - Clinical Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210414
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adiposity
MH  - Adult
MH  - Bariatric Surgery/instrumentation/*methods
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/complications/*surgery
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - *Insulin Resistance
MH  - Jejunum/surgery
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*surgery
MH  - *Prostheses and Implants
MH  - Weight Loss
PMC - PMC8070956
OTO - NOTNLM
OT  - Botnia clamp
OT  - EndoBarrier
OT  - duodenal-jejunal bypass liner
OT  - obesity
OT  - type 2 diabetes mellitus
COIS- No conflicts related to this study are reported.
EDAT- 2021/05/01 06:00
MHDA- 2021/09/21 06:00
PMCR- 2021/04/14
CRDT- 2021/04/30 01:14
PHST- 2021/02/04 00:00 [received]
PHST- 2021/03/05 00:00 [revised]
PHST- 2021/04/12 00:00 [accepted]
PHST- 2021/04/30 01:14 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2021/04/14 00:00 [pmc-release]
AID - biom11040574 [pii]
AID - biomolecules-11-00574 [pii]
AID - 10.3390/biom11040574 [doi]
PST - epublish
SO  - Biomolecules. 2021 Apr 14;11(4):574. doi: 10.3390/biom11040574.