PMID- 33920823
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 2079-6382 (Print)
IS  - 2079-6382 (Electronic)
IS  - 2079-6382 (Linking)
VI  - 10
IP  - 4
DP  - 2021 Apr 15
TI  - Denture-Soaking Solution Containing Piper betle Extract-Loaded Polymeric 
      Micelles; Inhibition of Candida albicans, Clinical Study, and Effects on Denture 
      Base Resin.
LID - 10.3390/antibiotics10040440 [doi]
LID - 440
AB  - Candida albicans is a common overgrowth in people wearing dentures. Long-term use 
      of antifungal chemicals carries a risk of toxic side effects. This study focused 
      on the edible Piper betle extract because of its safety. The broth dilution 
      method was applied for antifungal determination of the ethyl acetate fractionated 
      extract (fEA) and fEA-loaded polymeric micelles (PMF). The PMF was prepared by 
      thin-film hydration using poloxamer 407 as a polymer base. The results found that 
      the weight ratio of fEA to polymer is the main factor to obtain PMF system as a 
      clear solution, nanoparticle sizes, narrow size distribution, negative zeta 
      potential, and high entrapment efficiency. The activity of PMF against C. 
      albicans is significantly higher than fEA alone, with a minimum fungicidal 
      concentration of 1.5 mg/mL. PMF from 1:3 ratio of fEA to polymer is used to 
      develop a denture-soaking solution contained 1.5 mg fEA/mL (PMFS). A clinical 
      study on dentures of 15 volunteers demonstrated an 86.1 +/- 9.2% reduction of C. 
      albicans after soaking the dentures in PMFS daily for 14 days. Interestingly, 
      PMFS did not change the hardness and roughness of the denture base resins. The 
      developed PMFS may serve as a potential natural denture-soaking solution against 
      candidiasis in denture wearers.
FAU - Okonogi, Siriporn
AU  - Okonogi S
AUID- ORCID: 0000-0001-6077-5017
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai 
      University, Chiang Mai 50200, Thailand.
AD  - Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang 
      Mai 50200, Thailand.
FAU - Phumat, Pimpak
AU  - Phumat P
AD  - Interdisciplinary Program in Nanoscience and Nanotechnology, Faculty of Science, 
      Chiang Mai University, Chiang Mai 50200, Thailand.
FAU - Khongkhunthian, Sakornrat
AU  - Khongkhunthian S
AD  - Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang 
      Mai 50200, Thailand.
AD  - Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, 
      Chiang Mai University, Chiang Mai 50200, Thailand.
FAU - Suttiat, Kullapop
AU  - Suttiat K
AD  - Department of Prosthodontics, Faculty of Dentistry, Chiang Mai University, Chiang 
      Mai 50200, Thailand.
FAU - Chaijareenont, Pisaisit
AU  - Chaijareenont P
AD  - Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang 
      Mai 50200, Thailand.
AD  - Department of Prosthodontics, Faculty of Dentistry, Chiang Mai University, Chiang 
      Mai 50200, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20210415
PL  - Switzerland
TA  - Antibiotics (Basel)
JT  - Antibiotics (Basel, Switzerland)
JID - 101637404
PMC - PMC8071126
OTO - NOTNLM
OT  - PMMA
OT  - Piper betle
OT  - anti-candidiasis
OT  - denture-soaking solution
OT  - poloxamer
OT  - polymeric micelles
OT  - solubility
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/15
CRDT- 2021/04/30 01:16
PHST- 2021/02/24 00:00 [received]
PHST- 2021/04/10 00:00 [revised]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/04/30 01:16 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/15 00:00 [pmc-release]
AID - antibiotics10040440 [pii]
AID - antibiotics-10-00440 [pii]
AID - 10.3390/antibiotics10040440 [doi]
PST - epublish
SO  - Antibiotics (Basel). 2021 Apr 15;10(4):440. doi: 10.3390/antibiotics10040440.