PMID- 33920885
OWN - NLM
STAT- MEDLINE
DCOM- 20210524
LR  - 20210524
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 26
IP  - 8
DP  - 2021 Apr 15
TI  - Anti-Inflammatory Properties In Vitro and Hypoglycaemic Effects of Phenolics from 
      Cultivated Fruit Body of Phellinus baumii in Type 2 Diabetic Mice.
LID - 10.3390/molecules26082285 [doi]
LID - 2285
AB  - Dietary intervention in type 2 diabetes mellitus (T2DM) is a hotspot in 
      international research because of potential threats to human health. Phellinus 
      baumii, a wild fungus traditionally used as a food and medicine source, is now 
      cultivated in certain East Asian countries, and is rich in polyphenols, which are 
      effective anti-inflammatory ingredients useful in treatment of T2DM, with fewer 
      side effects than drugs. To examine the hypoglycaemic effects of Phellinus baumii 
      phenolics (PPE), the metabolite profiles of T2DM mice induced by streptozotocin 
      after PPE intervention were systematically analyzed. Here, 10 normal mice were 
      given normal saline as control group, and 50 model mice were randomly assigned to 
      five groups and daily intragastric administrated with saline, metformin (100 
      mg/kg), and PPE (50, 100, 150 mg/kg of body weight), for 60 days. The 
      pro-inflammatory factor contents of lipopolysaccharide stimulation of RAW 264.7 
      cells were decreased in a dose-dependent manner after PPE treatment, we propose 
      that PPE could exert anti-inflammatory properties. PPE could also effectively 
      reduce blood glucose levels, increased insulin sensitivity, and improved other 
      glucolipid metabolism. Q-PCR results suggested that the hypoglycemic effects of 
      PPE might be through activating IRS1/PI3K/AKT pathway in diabetic mice. These 
      results suggest that PPE has strong potential as dietary components in the 
      prevention or management of T2DM.
FAU - Yang, Kai
AU  - Yang K
AUID- ORCID: 0000-0001-5571-6645
AD  - College of Food Science and Technology, Zhejiang University of Technology, 
      Hangzhou 310014, China.
FAU - Zhang, Su
AU  - Zhang S
AD  - College of Food Science and Technology, Zhejiang University of Technology, 
      Hangzhou 310014, China.
FAU - Geng, Yan
AU  - Geng Y
AD  - College of Food Science and Technology, Zhejiang University of Technology, 
      Hangzhou 310014, China.
FAU - Tian, Baoming
AU  - Tian B
AD  - College of Food Science and Technology, Zhejiang University of Technology, 
      Hangzhou 310014, China.
FAU - Cai, Ming
AU  - Cai M
AUID- ORCID: 0000-0003-0782-9877
AD  - College of Food Science and Technology, Zhejiang University of Technology, 
      Hangzhou 310014, China.
FAU - Guan, Rongfa
AU  - Guan R
AD  - College of Food Science and Technology, Zhejiang University of Technology, 
      Hangzhou 310014, China.
FAU - Li, Yougui
AU  - Li Y
AD  - Sericultural Research Institute, Zhejiang Academy of Agricultural Sciences, 
      Hangzhou 310021, China.
FAU - Ye, Bangwei
AU  - Ye B
AD  - Zhejiang WisePlus Health Technology Co., Ltd., Lishui 323006, China.
FAU - Sun, Peilong
AU  - Sun P
AUID- ORCID: 0000-0003-1963-1120
AD  - College of Food Science and Technology, Zhejiang University of Technology, 
      Hangzhou 310014, China.
LA  - eng
GR  - 2019C02040/the key research and development projects of Zhejiang Province/
GR  - 2018C02003/the key research and development projects of Zhejiang Province/
PT  - Journal Article
DEP - 20210415
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Phenols)
RN  - Sanghuangporus baumii
SB  - IM
MH  - Animals
MH  - Basidiomycota/drug effects/pathogenicity
MH  - Diabetes Mellitus, Experimental/drug therapy
MH  - Diabetes Mellitus, Type 2/drug therapy
MH  - Humans
MH  - Hypoglycemia/drug therapy
MH  - Hypoglycemic Agents/therapeutic use
MH  - Lipopolysaccharides/physiology
MH  - Mice
MH  - Phellinus/*chemistry
MH  - Phenols/*therapeutic use
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Polymerase Chain Reaction
MH  - RAW 264.7 Cells
PMC - PMC8071318
OTO - NOTNLM
OT  - Phellinus baumii
OT  - anti-inflammatory properties
OT  - hypoglycemic effects
OT  - phenolics
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/25 06:00
PMCR- 2021/04/15
CRDT- 2021/04/30 01:17
PHST- 2021/03/18 00:00 [received]
PHST- 2021/04/12 00:00 [revised]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/04/30 01:17 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/25 06:00 [medline]
PHST- 2021/04/15 00:00 [pmc-release]
AID - molecules26082285 [pii]
AID - molecules-26-02285 [pii]
AID - 10.3390/molecules26082285 [doi]
PST - epublish
SO  - Molecules. 2021 Apr 15;26(8):2285. doi: 10.3390/molecules26082285.