PMID- 3392141
OWN - NLM
STAT- MEDLINE
DCOM- 19880818
LR  - 20190629
VI  - 426
IP  - 2
DP  - 1988 Apr 29
TI  - High-performance liquid chromatographic separation and electrochemical or 
      spectrophotometric determination of R(-)N-n-propylnorapomorphine and 
      R(-)10,11-methylenedioxy-N-n-propylnoraporphine in primate plasma.
PG  - 283-94
AB  - The dopamine receptor agonist R(-)N-n-propylnorapomorphine (NPA) and its proposed 
      pro-drug R(-)10,11-methylenedioxy-N-n-propylnoraporphine (MDO-NPA) were isolated 
      simultaneously from monkey plasma using a solid-phase extraction procedure. 
      R(-)Apomorphine (APO) and R(-)10,11-methylenedioxyaporphine (MDO-APO) were added 
      as internal standards, and separation and quantification were by high-performance 
      liquid chromatography with electrochemical or ultraviolet detection of the free 
      catechol and MDO compounds, respectively. The detection limits for NPA and 
      MDO-NPA in plasma were 0.5 and 10 ng/ml and the coefficient of variation 
      (S.D./mean) within assays and between days of assays for both drugs was 5.6% or 
      less. Quantification of plasma levels of NPA and MDO-NPA was possible at ranges 
      of 2-1000 and 40-5000 ng/ml, respectively, including concentrations found after 
      intravenous administration of these agents.
FAU - Lampen, P
AU  - Lampen P
AD  - Section of Medicinal Chemistry, College of Pharmacy and Allied Health 
      Professions, Northeastern University, Boston, MA 02115.
FAU - Neumeyer, J L
AU  - Neumeyer JL
FAU - Baldessarini, R J
AU  - Baldessarini RJ
LA  - eng
GR  - MH-34006/MH/NIMH NIH HHS/United States
GR  - MH-47370/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Chromatogr
JT  - Journal of chromatography
JID - 0427043
RN  - 0 (Aporphines)
RN  - 58479-52-0 (N-n-propylnorapomorphine)
RN  - 81264-57-5 (10,11-methylenedioxy-N-propylnoraporphine)
RN  - N21FAR7B4S (Apomorphine)
SB  - IM
MH  - Animals
MH  - Apomorphine/*analogs & derivatives/blood/pharmacokinetics
MH  - Aporphines/blood
MH  - Chromatography, High Pressure Liquid
MH  - Electrochemistry
MH  - Macaca fascicularis
MH  - Spectrophotometry, Ultraviolet
EDAT- 1988/04/29 00:00
MHDA- 1988/04/29 00:01
CRDT- 1988/04/29 00:00
PHST- 1988/04/29 00:00 [pubmed]
PHST- 1988/04/29 00:01 [medline]
PHST- 1988/04/29 00:00 [entrez]
AID - 10.1016/s0378-4347(00)81956-8 [doi]
PST - ppublish
SO  - J Chromatogr. 1988 Apr 29;426(2):283-94. doi: 10.1016/s0378-4347(00)81956-8.