PMID- 33921690
OWN - NLM
STAT- MEDLINE
DCOM- 20211020
LR  - 20230920
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 4
DP  - 2021 Apr 19
TI  - Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and 
      Neuroinflammation in Mood Disorders?
LID - 10.3390/cells10040941 [doi]
LID - 941
AB  - Affective disorders (AD) including major depressive disorder (MDD) and bipolar 
      disorder (BD) are common mood disorders associated with increased disability and 
      poor health outcomes. Altered immune responses characterized by increased serum 
      levels of pro-inflammatory cytokines and neuroinflammation are common findings in 
      patients with AD and in corresponding animal models. Dendritic cells (DCs) 
      represent a heterogeneous population of myeloid cells that orchestrate innate and 
      adaptive immune responses and self-tolerance. Upon sensing exogenous and 
      endogenous danger signals, mature DCs secrete proinflammatory factors, acquire 
      migratory and antigen presenting capacities and thus contribute to 
      neuroinflammation in trauma, autoimmunity, and neurodegenerative diseases. 
      However, little is known about the involvement of DCs in the pathogenesis of AD. 
      In this review, we summarize the current knowledge on DCs in peripheral immune 
      responses and neuroinflammation in MDD and BD. In addition, we consider the 
      impact of DCs on neuroinflammation and behavior in animal models of AD. Finally, 
      we will discuss therapeutic perspectives targeting DCs and their effector 
      molecules in mood disorders.
FAU - Leite Dantas, Rafael
AU  - Leite Dantas R
AD  - Department of Mental Health, University of Munster, 48149 Munster, Germany.
AD  - Cells in Motion Interfaculty Centre, University of Munster, 48149 Munster, 
      Germany.
FAU - Freff, Jana
AU  - Freff J
AD  - Department of Mental Health, University of Munster, 48149 Munster, Germany.
AD  - Cells in Motion Interfaculty Centre, University of Munster, 48149 Munster, 
      Germany.
FAU - Ambree, Oliver
AU  - Ambree O
AD  - Department of Behavioural Biology, University of Osnabruck, 49076 Osnabruck, 
      Germany.
AD  - Center of Cellular Nanoanalytics, University of Osnabruck, 49076 Osnabruck, 
      Germany.
FAU - Beins, Eva C
AU  - Beins EC
AUID- ORCID: 0000-0002-7779-0210
AD  - Institute of Human Genetics, University of Bonn, School of Medicine & University 
      Hospital Bonn, 53127 Bonn, Germany.
FAU - Forstner, Andreas J
AU  - Forstner AJ
AD  - Institute of Human Genetics, University of Bonn, School of Medicine & University 
      Hospital Bonn, 53127 Bonn, Germany.
AD  - Institute of Neuroscience and Medicine (INM-1), Research Center Julich, 52428 
      Julich, Germany.
FAU - Dannlowski, Udo
AU  - Dannlowski U
AD  - Department of Mental Health, University of Munster, 48149 Munster, Germany.
FAU - Baune, Bernhard T
AU  - Baune BT
AD  - Department of Mental Health, University of Munster, 48149 Munster, Germany.
AD  - Department of Psychiatry, Melbourne Medical School, The University of Melbourne, 
      Parkville, VIC 3010, Australia.
AD  - The Florey Institute of Neuroscience and Mental Health, The University of 
      Melbourne, Parkville, VIC 3010, Australia.
FAU - Scheu, Stefanie
AU  - Scheu S
AUID- ORCID: 0000-0002-9707-8191
AD  - Institute of Medical Microbiology and Hospital Hygiene, University of Dusseldorf, 
      40225 Dusseldorf, Germany.
FAU - Alferink, Judith
AU  - Alferink J
AUID- ORCID: 0000-0002-3251-6584
AD  - Department of Mental Health, University of Munster, 48149 Munster, Germany.
AD  - Cells in Motion Interfaculty Centre, University of Munster, 48149 Munster, 
      Germany.
LA  - eng
GR  - Grant FF-2014-01 DFG EXC 1003 for JA/Deutsche Forschungsgemeinschaft/
GR  - AL1145/5-2 for JA/Deutsche Forschungsgemeinschaft/
GR  - 270650915/GRK2158 for SS/Deutsche Forschungsgemeinschaft/
GR  - SCHE692/6-1 for SS/Deutsche Forschungsgemeinschaft/
GR  - Molecules of Infection III to SS/Manchot Graduate Schools/
GR  - Molecules of Infection IV to SS/Manchot Graduate Schools/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210419
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Animals
MH  - Behavior
MH  - Dendritic Cells/*immunology
MH  - Depression/immunology
MH  - Humans
MH  - *Immunity
MH  - Inflammation/*immunology/pathology
MH  - Mood Disorders/*immunology
PMC - PMC8072712
OTO - NOTNLM
OT  - bipolar disorder
OT  - dendritic cell
OT  - inflammation
OT  - innate immune response
OT  - major depressive disorder
OT  - mood disorder
OT  - neuroinflammation
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/05/01 06:00
MHDA- 2021/10/21 06:00
PMCR- 2021/04/19
CRDT- 2021/04/30 01:19
PHST- 2021/02/21 00:00 [received]
PHST- 2021/03/25 00:00 [revised]
PHST- 2021/04/07 00:00 [accepted]
PHST- 2021/04/30 01:19 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/04/19 00:00 [pmc-release]
AID - cells10040941 [pii]
AID - cells-10-00941 [pii]
AID - 10.3390/cells10040941 [doi]
PST - epublish
SO  - Cells. 2021 Apr 19;10(4):941. doi: 10.3390/cells10040941.