PMID- 33921996
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 9
DP  - 2021 Apr 22
TI  - Safety and Feasibility of MitraClip Implantation in Patients with Acute Mitral 
      Regurgitation after Recent Myocardial Infarction and Severe Left Ventricle 
      Dysfunction.
LID - 10.3390/jcm10091819 [doi]
LID - 1819
AB  - Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) 
      have an increased risk of mortality. Transcatheter mitral valve repair may 
      therefore be a suitable therapy. However, data on clinical outcomes of patients 
      in an acute setting are scarce, especially those with reduced left ventricle (LV) 
      dysfunction. We conducted a multinational, collaborative data analysis from 21 
      centers for patients who were, within 90 days of acute MI, treated with MitraClip 
      due to severe MR. The cohort was divided according to median left ventricle 
      ejection fraction (LVEF)-35%. Included in the study were 105 patients. The mean 
      age was 71 +/- 10 years. Patients in the LVEF < 35% group were younger but with 
      comparable Euroscore II, multivessel coronary artery disease, prior MI and 
      coronary artery bypass graft surgery. Procedure time was comparable and acute 
      success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was 
      significantly reduced in both groups along with an immediate reduction in left 
      atrial V-wave, pulmonary artery pressure and improvement in New York Heart 
      Association (NYHA) class. In-hospital and 1-year mortality rates were not 
      significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 
      12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In 
      conclusion, MitraClip intervention in patients with acute severe functional 
      mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and 
      feasible. Even patients with severe LV dysfunction may benefit from transcatheter 
      mitral valve intervention and should not be excluded.
FAU - Haberman, Dan
AU  - Haberman D
AUID- ORCID: 0000-0003-2897-8919
AD  - Heart Center, Kaplan Medical Center, Affiliated to the Hebrew University, 
      Jerusalem 9190501, Israel.
FAU - Estevez-Loureiro, Rodrigo
AU  - Estevez-Loureiro R
AD  - Interventional Cardiology Unit, Hospital Alvaro Cunqueiro, 36321 Vigo, Spain.
FAU - Benito-Gonzalez, Tomas
AU  - Benito-Gonzalez T
AUID- ORCID: 0000-0002-8428-9248
AD  - Interventional Cardiology Unit, Complejo Asistencial Universitario de Leon, 24071 
      Leon, Spain.
FAU - Denti, Paolo
AU  - Denti P
AUID- ORCID: 0000-0002-3075-0203
AD  - Cardiovascular Surgery Department, San Raffaele University Hospital, 20132 Milan, 
      Italy.
FAU - Arzamendi, Dabit
AU  - Arzamendi D
AD  - Interventional Cardiology Unit, Hospital Sant Pau i Santa Creu, 08041 Barcelona, 
      Spain.
FAU - Adamo, Marianna
AU  - Adamo M
AD  - Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia, 25123 
      Brescia, Italy.
FAU - Freixa, Xavier
AU  - Freixa X
AD  - Interventional Cardiology Unit, Hospital Clinic, 08036 Barcelona, Spain.
FAU - Nombela-Franco, Luis
AU  - Nombela-Franco L
AUID- ORCID: 0000-0003-3438-8907
AD  - Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria San Carlos, 
      IdISSC, 28040 Madrid, Spain.
FAU - Villablanca, Pedro
AU  - Villablanca P
AD  - Interventional Cardiology, The Center for Structural Heart Disease, Henry Ford 
      Hospital, Detroit, MI 48202, USA.
FAU - Krivoshei, Lian
AU  - Krivoshei L
AD  - Department of Cardiology, Kantonsspital Baden, 5404 Baden, Switzerland.
FAU - Fam, Neil
AU  - Fam N
AD  - Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, 
      ON M5B 1W8, Canada.
FAU - Spargias, Konstantinos
AU  - Spargias K
AD  - Department of Transcatheter Heart Valves, HYGEIA Hospital, 15123 Athens, Greece.
FAU - Czarnecki, Andrew
AU  - Czarnecki A
AD  - Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, 
      Toronto, ON M4N 3M5, Canada.
FAU - Pascual, Isaac
AU  - Pascual I
AUID- ORCID: 0000-0001-5433-1364
AD  - Department of Cardiology, Hospital Universitario Central de Asturias, 33011 
      Oviedo, Spain.
FAU - Praz, Fabien
AU  - Praz F
AD  - Inselspital, Bern University Hospital, University of Bern, 3010 Bern, 
      Switzerland.
FAU - Sudarsky, Doron
AU  - Sudarsky D
AD  - Cardiovascular Institute, Baruch Padeh Medical Center, Poriya 1520800, Israel.
FAU - Kerner, Arthur
AU  - Kerner A
AD  - Department of Cardiology, Rambam Medical Center, and B. Rappaport Faculty of 
      Medicine, Technion Medical School, Haifa 3109601, Israel.
FAU - Ninios, Vlasis
AU  - Ninios V
AD  - Department of Cardiology, Interbalkan European Medical Center, 55535 
      Thessaloniki, Greece.
FAU - Gennari, Marco
AU  - Gennari M
AD  - Department of Cardiovascular Surgery, IRCCS Centro Cardiologico Monzino, 20138 
      Milan, Italy.
AD  - Heart Valve Clinic, University Hospital of Zurich, 8006 Zurich, Switzerland.
FAU - Beeri, Ronen
AU  - Beeri R
AUID- ORCID: 0000-0002-8014-0702
AD  - Heart Institute, Hadassah-Hebrew University Medical Center, Jerusalem 91120, 
      Israel.
FAU - Perl, Leor
AU  - Perl L
AUID- ORCID: 0000-0002-0625-7937
AD  - Cardiology Department, Rabin Medical Center and the "Sackler" Faculty of 
      Medicine, Tel-Aviv University, Tel-Aviv 49100, Israel.
FAU - Danenberg, Haim
AU  - Danenberg H
AD  - Heart Institute, Hadassah-Hebrew University Medical Center, Jerusalem 91120, 
      Israel.
FAU - Poles, Lion
AU  - Poles L
AD  - Heart Center, Kaplan Medical Center, Affiliated to the Hebrew University, 
      Jerusalem 9190501, Israel.
FAU - Shimoni, Sara
AU  - Shimoni S
AD  - Heart Center, Kaplan Medical Center, Affiliated to the Hebrew University, 
      Jerusalem 9190501, Israel.
FAU - Goland, Sorel
AU  - Goland S
AD  - Heart Center, Kaplan Medical Center, Affiliated to the Hebrew University, 
      Jerusalem 9190501, Israel.
FAU - Caneiro-Queija, Berenice
AU  - Caneiro-Queija B
AD  - Interventional Cardiology Unit, Hospital Alvaro Cunqueiro, 36321 Vigo, Spain.
FAU - Scianna, Salvatore
AU  - Scianna S
AD  - Heart Valve Clinic, University Hospital of Zurich, 8006 Zurich, Switzerland.
FAU - Moaraf, Igal
AU  - Moaraf I
AD  - Department of Cardiology, Kantonsspital Baden, 5404 Baden, Switzerland.
FAU - Schiavi, Davide
AU  - Schiavi D
AUID- ORCID: 0000-0002-3081-1678
AD  - Cardiovascular Surgery Department, San Raffaele University Hospital, 20132 Milan, 
      Italy.
FAU - Scardino, Claudia
AU  - Scardino C
AD  - Department of Cardiology, Joan XXIII University Hospital, 43005 Tarragona, Spain.
FAU - Corpataux, Noe
AU  - Corpataux N
AUID- ORCID: 0000-0001-9514-6835
AD  - Inselspital, Bern University Hospital, University of Bern, 3010 Bern, 
      Switzerland.
FAU - Echarte-Morales, Julio
AU  - Echarte-Morales J
AD  - Interventional Cardiology Unit, Complejo Asistencial Universitario de Leon, 24071 
      Leon, Spain.
FAU - Chrissoheris, Michael
AU  - Chrissoheris M
AD  - Department of Transcatheter Heart Valves, HYGEIA Hospital, 15123 Athens, Greece.
FAU - Fernandez-Peregrina, Estefania
AU  - Fernandez-Peregrina E
AUID- ORCID: 0000-0002-3025-8251
AD  - Interventional Cardiology Unit, Hospital Sant Pau i Santa Creu, 08041 Barcelona, 
      Spain.
FAU - Di Pasquale, Mattia
AU  - Di Pasquale M
AD  - Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia, 25123 
      Brescia, Italy.
FAU - Regueiro, Ander
AU  - Regueiro A
AUID- ORCID: 0000-0001-5201-447X
AD  - Interventional Cardiology Unit, Hospital Clinic, 08036 Barcelona, Spain.
FAU - Vergara-Uzcategui, Carlos
AU  - Vergara-Uzcategui C
AUID- ORCID: 0000-0001-7855-9128
AD  - Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria San Carlos, 
      IdISSC, 28040 Madrid, Spain.
FAU - Iniguez-Romo, Andres
AU  - Iniguez-Romo A
AD  - Interventional Cardiology Unit, Hospital Alvaro Cunqueiro, 36321 Vigo, Spain.
FAU - Fernandez-Vazquez, Felipe
AU  - Fernandez-Vazquez F
AUID- ORCID: 0000-0001-7187-1290
AD  - Interventional Cardiology Unit, Complejo Asistencial Universitario de Leon, 24071 
      Leon, Spain.
FAU - Dvir, Danny
AU  - Dvir D
AD  - Jesselson Integrated Heart Centre, Shaare Zedek Medical Center, Hebrew 
      University, Jerusalem 9103102, Israel.
FAU - Taramasso, Maurizio
AU  - Taramasso M
AD  - Heart Valve Clinic, University Hospital of Zurich, 8006 Zurich, Switzerland.
FAU - Shuvy, Mony
AU  - Shuvy M
AD  - Heart Institute, Hadassah-Hebrew University Medical Center, Jerusalem 91120, 
      Israel.
AD  - Jesselson Integrated Heart Centre, Shaare Zedek Medical Center, Hebrew 
      University, Jerusalem 9103102, Israel.
LA  - eng
PT  - Journal Article
DEP - 20210422
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8122348
OTO - NOTNLM
OT  - acute myocardial infarction
OT  - left ventricle dysfunction
OT  - mitral regurgitation
OT  - percutaneous mitral valve repair
COIS- Dan Haberman is an Abbott CEC member. Rodrigo Estevez-Loureiro, Dabit Arzamendi, 
      Paolo Denti, Xavier Freixa, are consultants for Abbott. Andrew Czarnecki received 
      speaker fee from Abbott and consultant for Caisson Interventional and Baylis 
      Medical. Marco Gennari is consultant for Medtronic. Luis Nombela-Franco has 
      served as a proctor of Abbott Vascular and received speakers' honoraria from 
      Boston Scientific and Abbott Vascular. Francesco Maisano has served as a 
      consultant for Abbott Vascular, Edwards Lifesciences, Cardiovalve, Valtech, and 
      Medtronic; and is cofounder of 4tech. Maurizio Taramasso is Consultant for 
      Abbott, Boston Scientific, 4tech and receives personal fees from Edwards 
      Lifescience, CoreMedic, Swissvortex and Mitraltech. Mony Shuvy is a proctor and 
      consultant for Abbott and consultant for Edwards Lifesciences. All other authors 
      have reported that they have no relationship relevant to the contents of this 
      paper to disclose.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/22
CRDT- 2021/04/30 01:20
PHST- 2021/02/25 00:00 [received]
PHST- 2021/04/05 00:00 [revised]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/04/30 01:20 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/22 00:00 [pmc-release]
AID - jcm10091819 [pii]
AID - jcm-10-01819 [pii]
AID - 10.3390/jcm10091819 [doi]
PST - epublish
SO  - J Clin Med. 2021 Apr 22;10(9):1819. doi: 10.3390/jcm10091819.