PMID- 33922216 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210527 IS - 2075-4426 (Print) IS - 2075-4426 (Electronic) IS - 2075-4426 (Linking) VI - 11 IP - 5 DP - 2021 Apr 22 TI - The Association of IgE Levels with ADAM33 Genetic Polymorphisms among Asthmatic Patients. LID - 10.3390/jpm11050329 [doi] LID - 329 AB - Total serum immunoglobulin E (IgE) is elevated in multiple allergic diseases and is considered a good predictor of atopy. Several studies have been performed on the association of IgE levels with the polymorphism of the ADAM33 gene in asthmatic patients. The aim of this study was to determine whether there is an association between IgE levels and the genetic polymorphisms of the ADAM33 gene (T1, T2, T + 1, V4, S1, S2, and Q-1) in both healthy and asthmatic patients among Jordanians. The clinical data were collected for this case-control study from 267 asthmatic patients and 225 control subjects. Seven genetic polymorphisms (T1, T2, T + 1, V4, S1, S2, and Q-1) of the gene ADAM33 were analyzed using the polymerase chain reaction/restriction fragment length polymorphism method. The minor alleles (G) of T1, (A) of T2, T + 1, and (G) of V4 polymorphisms were associated with a significant increase in total serum IgE levels in adults but not children. The V4 genetic polymorphism, however, showed a significant association with IgE levels in both adults and children. The S1 polymorphism was significantly associated with the codominant module only in the adults. The S2 polymorphism showed a significant association (p-value < 0.05) in both codominant and recessive models. However, in the dominant model for both pediatric control and asthmatic patients, the association between the IgE and S2 polymorphism was insignificant (p-value = 0.7271 and 0.5259, respectively). This study found a statistically significant association between multiple ADAM33 genetic polymorphisms and IgE levels. Such findings add to the growing evidence that the ADAM33 gene has a major impact on IgE levels among asthmatic patients of Jordanian origin. FAU - Zihlif, Malek AU - Zihlif M AUID- ORCID: 0000-0002-5307-114X AD - Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Imraish, Amer AU - Imraish A AUID- ORCID: 0000-0003-1191-2905 AD - Department of Biology, Faculty of Science, The University of Jordan, Amman 11942, Jordan. FAU - Al-Rawashdeh, Baeth AU - Al-Rawashdeh B AUID- ORCID: 0000-0003-2648-0180 AD - Department of Special Surgery, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Qteish, Aya AU - Qteish A AD - Department of Special Surgery, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Husami, Raihan AU - Husami R AD - Department of Special Surgery, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Husami, Rawand AU - Husami R AD - Department of Special Surgery, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Tahboub, Farah AU - Tahboub F AD - Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Jarrar, Yazun AU - Jarrar Y AUID- ORCID: 0000-0002-5943-7229 AD - Department of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan. FAU - Lee, Su-Jun AU - Lee SJ AUID- ORCID: 0000-0002-3570-0598 AD - Department of Pharmacology, College of Medicine, Inje University, Busan 50834, Korea. LA - eng PT - Journal Article DEP - 20210422 PL - Switzerland TA - J Pers Med JT - Journal of personalized medicine JID - 101602269 PMC - PMC8146671 OTO - NOTNLM OT - ADAM33 OT - IgE OT - asthma OT - single-nucleotide polymorphism COIS- The authors declare no conflict of interest. EDAT- 2021/05/01 06:00 MHDA- 2021/05/01 06:01 PMCR- 2021/04/22 CRDT- 2021/04/30 01:21 PHST- 2020/11/25 00:00 [received] PHST- 2021/02/11 00:00 [revised] PHST- 2021/04/20 00:00 [accepted] PHST- 2021/04/30 01:21 [entrez] PHST- 2021/05/01 06:00 [pubmed] PHST- 2021/05/01 06:01 [medline] PHST- 2021/04/22 00:00 [pmc-release] AID - jpm11050329 [pii] AID - jpm-11-00329 [pii] AID - 10.3390/jpm11050329 [doi] PST - epublish SO - J Pers Med. 2021 Apr 22;11(5):329. doi: 10.3390/jpm11050329.