PMID- 33922329
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 5
DP  - 2021 Apr 22
TI  - Macrophages and Immune Responses in Uterine Fibroids.
LID - 10.3390/cells10050982 [doi]
LID - 982
AB  - Uterine fibroids represent the most common benign tumors of the uterus. They are 
      considered a typical fibrotic disorder. In fact, the extracellular matrix (ECM) 
      proteins-above all, collagen 1A1, fibronectin and versican-are upregulated in 
      this pathology. The uterine fibroids etiology has not yet been clarified, and 
      this represents an important matter about their resolution. A model has been 
      proposed according to which the formation of an altered ECM could be the result 
      of an excessive wound healing, in turn driven by a dysregulated inflammation 
      process. A lot of molecules act in the complex inflammatory response. Macrophages 
      have a great flexibility since they can assume different phenotypes leading to 
      the tissue repair process. The dysregulation of macrophage proliferation, 
      accumulation and infiltration could lead to an uncontrolled tissue repair and to 
      the consequent pathological fibrosis. In addition, molecules such as monocyte 
      chemoattractant protein-1 (MCP-1), granulocyte macrophage-colony-stimulating 
      factor (GM-CSF), transforming growth factor-beta (TGF-beta), activin A and tumor 
      necrosis factor-alfa (TNF-alpha) were demonstrated to play an important role in the 
      macrophage action within the uncontrolled tissue repair that contributes to the 
      pathological fibrosis that represents a typical feature of the uterine fibroids.
FAU - Zannotti, Alessandro
AU  - Zannotti A
AUID- ORCID: 0000-0001-6264-5873
AD  - Department of Specialist and Odontostomatological Clinical Sciences, Universita 
      Politecnica delle Marche, 60126 Ancona, Italy.
AD  - Department of Experimental and Clinical Medicine, Universita Politecnica delle 
      Marche, 60126 Ancona, Italy.
FAU - Greco, Stefania
AU  - Greco S
AD  - Department of Experimental and Clinical Medicine, Universita Politecnica delle 
      Marche, 60126 Ancona, Italy.
FAU - Pellegrino, Pamela
AU  - Pellegrino P
AD  - Department of Experimental and Clinical Medicine, Universita Politecnica delle 
      Marche, 60126 Ancona, Italy.
FAU - Giantomassi, Federica
AU  - Giantomassi F
AD  - Department of Biomedical Sciences and Public Health, Universita Politecnica delle 
      Marche, 60126 Ancona, Italy.
FAU - Delli Carpini, Giovanni
AU  - Delli Carpini G
AD  - Department of Specialist and Odontostomatological Clinical Sciences, Universita 
      Politecnica delle Marche, 60126 Ancona, Italy.
FAU - Goteri, Gaia
AU  - Goteri G
AD  - Department of Biomedical Sciences and Public Health, Universita Politecnica delle 
      Marche, 60126 Ancona, Italy.
FAU - Ciavattini, Andrea
AU  - Ciavattini A
AD  - Department of Specialist and Odontostomatological Clinical Sciences, Universita 
      Politecnica delle Marche, 60126 Ancona, Italy.
FAU - Ciarmela, Pasquapina
AU  - Ciarmela P
AD  - Department of Experimental and Clinical Medicine, Universita Politecnica delle 
      Marche, 60126 Ancona, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210422
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunity/*immunology
MH  - Leiomyoma/immunology/*pathology
MH  - Macrophages/*immunology
PMC - PMC8146588
OTO - NOTNLM
OT  - ECM
OT  - inflammatory process
OT  - macrophages
OT  - pathological fibrosis
OT  - tissue repair
OT  - uterine fibroids
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/11/09 06:00
PMCR- 2021/04/22
CRDT- 2021/04/30 01:21
PHST- 2021/03/25 00:00 [received]
PHST- 2021/04/19 00:00 [revised]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2021/04/30 01:21 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2021/04/22 00:00 [pmc-release]
AID - cells10050982 [pii]
AID - cells-10-00982 [pii]
AID - 10.3390/cells10050982 [doi]
PST - epublish
SO  - Cells. 2021 Apr 22;10(5):982. doi: 10.3390/cells10050982.