PMID- 33922631
OWN - NLM
STAT- MEDLINE
DCOM- 20210526
LR  - 20240226
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 5
DP  - 2021 Apr 23
TI  - Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty 
      Acids Production without Adverse Effects on Metabolism and Inflammation.
LID - 10.3390/nu13051427 [doi]
LID - 1427
AB  - Glycerol monocaprylate (GMC) is a glycerol derivative of medium-chain fatty acids 
      (MCFAs) and is widely used as a preservative in food processing. However, GMC and 
      its hydrolytic acid (octylic acid) have antibacterial properties that may affect 
      the physiology and intestinal microecology of the human body. Therefore, in this 
      study, the effects of two different dosages of GMC (150 and 1600 mg kg(-1)) on 
      glucose, lipid metabolism, inflammation, and intestinal microecology of normal 
      diet-fed C57BL/6 mice were comprehensively investigated. The obtained results 
      showed that the level of triglycerides (TGs) in the low-dose group down-regulated 
      significantly, and the anti-inflammatory cytokine interleukin 10 (IL-10) 
      significantly increased, while the pro-inflammatory cytokines monocyte 
      chemotactic protein 1 (MCP-1) and interleukin 1beta (IL-1beta) in the high-dose 
      group were significantly decreased. Importantly, GMC promoted the alpha-diversity of 
      gut microbiota in normal-diet-fed mice, regardless of dosages. Additionally, it 
      was found that the low-dose treatment of GMC significantly increased the 
      abundance of Lactobacillus, while the high-dose treatment of GMC significantly 
      increased the abundance of SCFA-producers such as Clostridiales, Lachnospiraceae, 
      and Ruminococcus. Moreover, the content of short-chain fatty acids (SCFAs) was 
      significantly increased by GMC supplementation. Thus, our research provides a 
      novel insight into the effects of GMC on gut microbiota and physiological 
      characteristics.
FAU - Zhang, Junhui
AU  - Zhang J
AUID- ORCID: 0000-0002-3599-2682
AD  - College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 
      310058, China.
AD  - National Engineering Laboratory of Intelligent Food Technology and Equipment, 
      Zhejiang University, Hangzhou 310058, China.
AD  - Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture 
      and Rural Affairs, Zhejiang University, Hangzhou 310058, China.
AD  - Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of 
      Agriculture, Zhejiang University, Hangzhou 310058, China.
AD  - Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.
FAU - Feng, Fengqin
AU  - Feng F
AUID- ORCID: 0000-0002-9770-1721
AD  - College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 
      310058, China.
AD  - National Engineering Laboratory of Intelligent Food Technology and Equipment, 
      Zhejiang University, Hangzhou 310058, China.
AD  - Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture 
      and Rural Affairs, Zhejiang University, Hangzhou 310058, China.
AD  - Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of 
      Agriculture, Zhejiang University, Hangzhou 310058, China.
AD  - Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.
FAU - Zhao, Minjie
AU  - Zhao M
AD  - College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 
      310058, China.
AD  - National Engineering Laboratory of Intelligent Food Technology and Equipment, 
      Zhejiang University, Hangzhou 310058, China.
AD  - Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture 
      and Rural Affairs, Zhejiang University, Hangzhou 310058, China.
AD  - Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of 
      Agriculture, Zhejiang University, Hangzhou 310058, China.
AD  - Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.
LA  - eng
GR  - 32072224/National Natural Science Foundation of China/
GR  - 32001693/National Natural Science Foundation of China/
GR  - 31972079/National Natural Science Foundation of China/
GR  - LD19C200001/Natural Science Foundation of Zhejiang Province/
GR  - LQ21C200007/Natural Science Foundation of Zhejiang Province/
GR  - LY18C200006/Natural Science Foundation of Zhejiang Province/
PT  - Journal Article
DEP - 20210423
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Cytokines)
RN  - 0 (Fatty Acids, Volatile)
RN  - 0 (Hormones)
RN  - IY9XDZ35W2 (Glucose)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adipocytes/drug effects
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cell Size/drug effects
MH  - Cytokines/blood
MH  - Fatty Acids, Volatile/*biosynthesis
MH  - Feeding Behavior/drug effects
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Glucose/metabolism
MH  - Glycerol/*pharmacology
MH  - Hormones/blood
MH  - Inflammation/blood/genetics/*microbiology/pathology
MH  - Lipid Metabolism/drug effects
MH  - Liver/drug effects/pathology
MH  - Male
MH  - Metabolism/*drug effects
MH  - Mice, Inbred C57BL
MH  - Mice
PMC - PMC8147114
OTO - NOTNLM
OT  - glucose and lipid metabolism
OT  - glycerol monocaprylate
OT  - gut microbiota
OT  - inflammation
OT  - short-chain fatty acids
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/27 06:00
PMCR- 2021/04/23
CRDT- 2021/04/30 01:22
PHST- 2021/03/04 00:00 [received]
PHST- 2021/04/21 00:00 [revised]
PHST- 2021/04/21 00:00 [accepted]
PHST- 2021/04/30 01:22 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/27 06:00 [medline]
PHST- 2021/04/23 00:00 [pmc-release]
AID - nu13051427 [pii]
AID - nutrients-13-01427 [pii]
AID - 10.3390/nu13051427 [doi]
PST - epublish
SO  - Nutrients. 2021 Apr 23;13(5):1427. doi: 10.3390/nu13051427.