PMID- 33922658
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 9
DP  - 2021 Apr 23
TI  - Functional Ambivalence of Dendritic Cells: Tolerogenicity and Immunogenicity.
LID - 10.3390/ijms22094430 [doi]
LID - 4430
AB  - Dendritic cells (DCs) are the most potent professional antigen-presenting cells 
      (APCs) and inducers of T cell-mediated immunity. Although DCs play a central role 
      in promoting adaptive immune responses against growing tumors, they also 
      establish and maintain peripheral tolerance. DC activity depends on the method of 
      induction and/or the presence of immunosuppressive agents. Tolerogenic dendritic 
      cells (tDCs) induce immune tolerance by activating CD4(+)CD25(+)Foxp3(+) 
      regulatory T (Treg) cells and/or by producing cytokines that inhibit T cell 
      activation. These findings suggest that tDCs may be an effective treatment for 
      autoimmune diseases, inflammatory diseases, and infertility.
FAU - Nam, Ji-Hee
AU  - Nam JH
AD  - Department of Biotechnology, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, 
      Gyeonggi-do 13488, Korea.
FAU - Lee, Jun-Ho
AU  - Lee JH
AUID- ORCID: 0000-0002-8386-9275
AD  - Pharos Vaccine Inc., 14 Galmachiro 288 bun-gil, Jungwon-gu, Seongnam, Gyeonggi-do 
      13201, Korea.
FAU - Choi, So-Yeon
AU  - Choi SY
AD  - Department of Biotechnology, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, 
      Gyeonggi-do 13488, Korea.
FAU - Jung, Nam-Chul
AU  - Jung NC
AUID- ORCID: 0000-0002-9250-3304
AD  - Pharos Vaccine Inc., 14 Galmachiro 288 bun-gil, Jungwon-gu, Seongnam, Gyeonggi-do 
      13201, Korea.
FAU - Song, Jie-Young
AU  - Song JY
AUID- ORCID: 0000-0002-5769-3886
AD  - Department of Radiation Cancer Sciences, Korea Institute of Radiological and 
      Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812, Korea.
FAU - Seo, Han-Geuk
AU  - Seo HG
AUID- ORCID: 0000-0002-9123-3816
AD  - Department of Food Science and Biotechnology of Animal Products, Sanghuh College 
      of Life Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, 
      Korea.
FAU - Lim, Dae-Seog
AU  - Lim DS
AUID- ORCID: 0000-0002-0637-4682
AD  - Department of Biotechnology, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, 
      Gyeonggi-do 13488, Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210423
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/immunology/*pathology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - Infertility/immunology/*pathology
MH  - Inflammation/immunology/*pathology
PMC - PMC8122871
OTO - NOTNLM
OT  - autoimmune disease
OT  - dendritic cells
OT  - immunotherapy
OT  - inflammatory disease
OT  - regulatory T cells
OT  - tolerogenicity
COIS- The authors declare no conflict of interest. Authors J.-H.L. and N.-C.J. were 
      employed by the company Pharos Vaccine, Inc. The remaining authors declare that 
      the research was conducted in the absence of any commercial or financial 
      relationships that could be construed as a potential conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/29 06:00
PMCR- 2021/04/23
CRDT- 2021/04/30 01:22
PHST- 2021/03/25 00:00 [received]
PHST- 2021/04/15 00:00 [revised]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2021/04/30 01:22 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2021/04/23 00:00 [pmc-release]
AID - ijms22094430 [pii]
AID - ijms-22-04430 [pii]
AID - 10.3390/ijms22094430 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Apr 23;22(9):4430. doi: 10.3390/ijms22094430.